anti-Human COPS5 Antikörper für Immunofluorescence

Recommended COPS5 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
  • BcDNA.LD14392
  • BcDNA:LD14392
  • CG14884
  • CH5
  • CSN-5
  • Csn5
  • DCH5
  • Dch5
  • Dmel\\CG14884
  • JAB1
  • JAB1/CSN5
  • Jab1
  • JadBp
  • csn5
  • dch5
  • jab1/csn5
  • l(3)89Cf
  • l(3)L4032
  • l(3)M203
  • quo
  • COPS5
  • MGC76063
  • AI303502
  • CSN5
  • Mov34
  • Sgn5
  • zgc:73130
  • MOV-34
  • SGN5
  • COP9 signalosome subunit 5
  • COP9 signalosome complex subunit 5
  • COP9 signalosome subunit 5 S homeolog
  • CSN5
  • COPS5
  • cops5
  • CpipJ_CPIJ012314
  • Bm1_46585
  • VDBG_06932
  • LOAG_01443
  • csn5
  • Cops5
  • cops5.S
  • csn-5
Epitop
AA 234-334
12
5
4
2
2
2
2
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
112
100
64
19
7
7
7
5
4
4
3
3
3
2
1
1
1
Wirt
Maus
68
54
1
Klonalität
Monoklonal
Konjugat
Dieser COPS5 Antikörper ist unkonjugiert
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
106
48
44
41
34
22
14
13
2
Optionen
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Produktnummer ABIN968614
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
11.772692 ABIN968615 IF WB Mouse IgG1 AA 234-334 Anmelden zum Anzeigen 42-JAB1 6
11.772692 ABIN1533317 IF ELISA WB Rabbit IgG AA 374-423 Anmelden zum Anzeigen Polyclonal 0
11.772692 ABIN4327830 ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
11.772692 ABIN5077577 ICC IF Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN267291 ICC IF IHC IP WB Mouse IgG2b Anmelden zum Anzeigen 2A10 8
1 ABIN1498920 IF IHC (p) WB Mouse IgG1 Anmelden zum Anzeigen 2B12 0
1 ABIN315581 ICC IF IHC (p) IP IHC WB Mouse IgG2b Anmelden zum Anzeigen 2A10-8 0
1 ABIN5611382 IF IHC (p) IP WB Mouse IgG2b Anmelden zum Anzeigen 2A10-8 0
1 ABIN5499241 IF IHC (p) IP WB Mouse IgG2b Anmelden zum Anzeigen 2A10-8 0
1 ABIN2469776 IF IP IHC WB Mouse IgG2b full length Anmelden zum Anzeigen 2A10-8 0
1 ABIN4327829 ICC IF IHC IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN2882092 IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1822333 IF IP WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN1977960 IF IHC (p) WB Rabbit IgG AA 175-225 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1977961 IF IHC (p) Rabbit IgG AA 175-225 Anmelden zum Anzeigen Polyclonal 0
1 ABIN4327833 ICC IF IHC WB DyLight 405 Mouse IgG2b Anmelden zum Anzeigen 2A10 0
1 ABIN4327838 ICC IF IHC WB DyLight 488 Mouse IgG2b Anmelden zum Anzeigen 2A10 0
1 ABIN4327840 ICC IF IHC WB DyLight 680 Mouse IgG2b Anmelden zum Anzeigen 2A10 0
1 ABIN4327842 ICC IF IHC WB Alexa Fluor 488 Mouse IgG2b Anmelden zum Anzeigen 2A10 0
1 ABIN4327843 ICC IF IHC WB Alexa Fluor 647 Mouse IgG2b Anmelden zum Anzeigen 2A10 0

General

Antigen COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) Antikörper
Epitop AA 234-334
(12), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(112), (100), (64), (19), (7), (7), (7), (5), (4), (4), (3), (3), (3), (2), (1), (1), (1)
Wirt Maus
(68), (54), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser COPS5 Antikörper ist unkonjugiert
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Western Blotting (WB)
(106), (48), (44), (41), (34), (22), (14), (13), (2)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-COPS5 Antikörper

Target Details COPS5 Anwendungsinformationen Handhabung Referenzen für anti-COPS5 Antikörper (ABIN968614) Bilder
Kreuzreaktivität Ratte (Rattus), Maus
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human JAB1 aa. 234-334
Klon 42-JAB1
Isotyp IgG1

Target Details COPS5

Produktdetails anti-COPS5 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-COPS5 Antikörper (ABIN968614) Bilder zurück nach oben
Antigen
Andere Bezeichnung JAB1 (COPS5 Antibody Abstract)
Hintergrund JAB1 (Jun activation domain-binding protein-1) was isolated in a yeast two- hybrid screen using the c-Jun N-terminal activation domain. Binding of JAB1 to Jun potentiates activator protein transcription factor (AP-1) target gene transcription. JAB1 interacts with c-Jun and JunD, but not with JunB or v-Jun. It also interacts with other transcriptional regulatory complexes, such as the activator of stromelysin 1 gene transcription complex (RNF4/SPBP) and the steroid receptor coactivator-1 complex. Additionally, JAB1 is the CSN5 subunit of the COP9 signalosome, which contains multiple proteins with homologies to proteins present in the 19S subunit of the proteosome. Interestingly, JAB1 has been implicated in the instigation of p27kip1 and rat lutropin/choriogonadotropin receptor degradation. JAB1 has also been found to be involved in integrin signaling cascades, because it colocalizes with the integrin LFA-1 receptor and is translocated to the nucleus, where it enhances transactivation of the AP-1- dependent promoter following integrin stimulation. Thus, JAB1 is a multifunctional protein that regulates both gene transcription and protein degradation.
Molekulargewicht 38 kDa
Pathways Zellzyklus

Anwendungsinformationen

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Handhabung Referenzen für anti-COPS5 Antikörper (ABIN968614) Bilder zurück nach oben
Kommentare

Related Products: ABIN968537, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Referenzen für anti-COPS5 Antikörper (ABIN968614) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20°C.

Referenzen für anti-COPS5 Antikörper (ABIN968614)

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Kamura, Hara, Matsumoto, Ishida, Okumura, Hatakeyama, Yoshida, Nakayama, Nakayama: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase." in: Nature cell biology, Vol. 6, Issue 12, pp. 1229-35, 2004

Ishida, Hara, Kamura, Yoshida, Nakayama, Nakayama: "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14355-8, 2002

Chauchereau, Georgiakaki, Perrin-Wolff, Milgrom, Loosfelt: "JAB1 interacts with both the progesterone receptor and SRC-1." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8540-8, 2000

Li, Liu, Ascoli: "p38JAB1 binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation." in: The Journal of biological chemistry, Vol. 275, Issue 18, pp. 13386-93, 2000

Tomoda, Kubota, Kato: "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1." in: Nature, Vol. 398, Issue 6723, pp. 160-5, 1999

Allgemeine Veröffentlichungen

Claret, Hibi, Dhut, Toda, Karin: "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors." in: Nature, Vol. 383, Issue 6599, pp. 453-7, 1996

Bilder

Produktdetails anti-COPS5 Antikörper Target Details COPS5 Anwendungsinformationen Handhabung Referenzen für anti-COPS5 Antikörper (ABIN968614) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 234-334) antibody (ABIN968614) Western blot analysis of JAB1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, la...
Immunofluorescence (IF) image for anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 234-334) antibody (ABIN968614) Immunofluorescent staining of A431 cells.