anti-Human BTRC Antikörper für Enzyme Immunoassay

Recommended BTRC Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
beta-Transducin Repeat Containing (BTRC) Antikörper
  • BTRC
  • Beta-TrCP
  • betaTrCP
  • btrcp
  • btrcp1
  • fbw1a
  • fbxw1
  • fbxw1a
  • fwd1
  • btrc
  • beta-TrCP
  • BETA-TRCP
  • FBW1A
  • FBXW1
  • FBXW1A
  • FWD1
  • bTrCP
  • bTrCP1
  • beta-TrCP1
  • btrc-a
  • Beta-Trcp1
  • Fbw1a
  • HOS
  • Slimb
  • b-TrCP
  • mKIAA4123
  • beta-transducin repeat containing E3 ubiquitin protein ligase
  • beta-transducin repeat containing
  • beta-TrCP
  • beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog
  • beta-transducin repeat containing protein
  • BTRC
  • btrc
  • LOC100634006
  • Btrc
  • btrc.S
Epitop
AA 24-60, N-Term
14
9
8
7
4
2
2
1
1
1
1
Reaktivität
Human
57
12
11
3
3
3
3
2
1
1
Wirt
Kaninchen
36
21
Klonalität
Polyklonal
Konjugat
Dieser BTRC Antikörper ist unkonjugiert
3
3
3
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
54
29
27
23
8
6
4
2
1
Hersteller
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Bilder

Produktnummer ABIN952275
$ 390.50
Zzgl. Versandkosten $45.00

General

Antigen beta-Transducin Repeat Containing (BTRC) Antikörper
Epitop AA 24-60, N-Term
(14), (9), (8), (7), (4), (2), (2), (1), (1), (1), (1)
Reaktivität Human
(57), (12), (11), (3), (3), (3), (3), (2), (1), (1)
Wirt Kaninchen
(36), (21)
Klonalität
Polyklonal
Konjugat Dieser BTRC Antikörper ist unkonjugiert
(3), (3), (3), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(54), (29), (27), (23), (8), (6), (4), (2), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-BTRC Antikörper

Target Details BTRC Anwendungsinformationen Handhabung Referenzen für anti-BTRC Antikörper (ABIN952275) Bilder
Spezifität This antibody reacts to FBW1A.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 24-60 amino acids from the N-terminal region of human BRTC1
Isotyp Ig Fraction
Plasmids, Primers & others

Target Details BTRC

Produktdetails anti-BTRC Antikörper Anwendungsinformationen Handhabung Referenzen für anti-BTRC Antikörper (ABIN952275) Bilder zurück nach oben
Antigen
Andere Bezeichnung FBW1A (BTRC Antibody Abstract)
Hintergrund This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.Synonyms: BTRC, BTRCP, E3RSIkappaB, F-box and WD repeats protein beta-TrCP, F-box/WD repeat-containing protein 1A, FBXW1A, pIkappaBalpha-E3 receptor subunit
Gen-ID 8945
NCBI Accession NP_003930
Pathways Zellzyklus, Hedgehog Signalweg

Anwendungsinformationen

Produktdetails anti-BTRC Antikörper Target Details BTRC Handhabung Referenzen für anti-BTRC Antikörper (ABIN952275) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-BTRC Antikörper Target Details BTRC Anwendungsinformationen Referenzen für anti-BTRC Antikörper (ABIN952275) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) sodium azide as preservative
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-BTRC Antikörper (ABIN952275)

Produktdetails anti-BTRC Antikörper Target Details BTRC Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Popov, Schülein, Jaenicke, Eilers: "Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover." in: Nature cell biology, Vol. 12, Issue 10, pp. 973-81, 2010

Inuzuka, Tseng, Gao, Zhai, Zhang, Shaik, Wan, Ang, Mock, Yin, Stommel, Gygi, Lahav, Asara, Xiao, Kaelin, Harper, Wei: "Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase." in: Cancer cell, Vol. 18, Issue 2, pp. 147-59, 2010

Guderian, Westendorf, Uldschmid, Nigg: "Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation." in: Journal of cell science, Vol. 123, Issue Pt 13, pp. 2163-9, 2010

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996

Bilder

Produktdetails anti-BTRC Antikörper Target Details BTRC Anwendungsinformationen Handhabung Referenzen für anti-BTRC Antikörper (ABIN952275) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-beta-Transducin Repeat Containing (BTRC) (AA 24-60), (N-Term) antibody (ABIN952275) Confocal immunofluorescent analysis of BRTC1 Antibody (N-term)(Cat#AP50409PU-N) with ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-beta-Transducin Repeat Containing (BTRC) (AA 24-60), (N-Term) antibody (ABIN952275) BRTC1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-beta-Transducin Repeat Containing (BTRC) (AA 24-60), (N-Term) antibody (ABIN952275) BRTC1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35µg/lane...