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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
Serum Wnt5a is elev (zeige IL6 Proteine)ated and as (zeige TIMP1 Proteine)sociated with disease severity in heart failure patients.
In squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder positive ROR2 (zeige ROR2 Proteine) or WNT5a expression is generally associated with a poor prognosis.
The Wnt5a and its signaling pathway can regulate fundamental cellular processes, including specification of cell fate, proliferation, and survival.
Results show that PTEN and WNT5A expression are directly repressed by miR (zeige MLXIP Proteine)-26b which promotes colorectal cancer metastasis.
The relationship between Wnt5a protein expression and histone H4K20me1 was analyzed. Recruitment of H4K20me1 and SET8 (zeige SETD8 Proteine) to the Wnt5a promoter and coding regions wa investigated. Results demonstrated that the expression levels of Wnt (zeige WNT2 Proteine) antagonists were generally low in acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)), but showed differential expression in acute lymphocytic leukemia (ALL).
WNT5A and IL-6 (zeige IL6 Proteine) are connected through a positive feedback loop in melanoma cells
this study reveals that 14-3-3zeta (zeige YWHAZ Proteine) plays a critical role in Wnt5a/ROR1 (zeige ROR1 Proteine) signaling, leading to enhanced CLL migration and proliferation.
these studies indicate HS1 (zeige EEF1A2 Proteine) plays an important role in ROR1 (zeige ROR1 Proteine)-dependent Wnt5a-enhanced chemokine (zeige CCL1 Proteine)-directed leukemia-cell migration.
Study reports that WNT5A bi-directionally regulates epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) in mammary epithelial cells, thereby affecting their migration and invasion. However, the ability of WNT5A to inhibit breast cancer cell migration and invasion is an EMT (zeige ITK Proteine)-independent mechanism that, at least in part, can be explained by decreased CD44 (zeige CD44 Proteine) expression.
disruption of trans-spliced noncoding RNA RMST expression in human embryonic stem cells results in the upregulation of WNT5A, epithelial-to-mesenchymal transition, and lineage-specific genes/markers.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (zeige WNT3A Proteine), acted across many cell diameters to orient Prickle3 (zeige PRICKLE3 Proteine)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (zeige ROR2 Proteine), which require Wnt5a/Ror2 (zeige ROR2 Proteine) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (zeige PCDH8 Proteine) signaling via RhoA (zeige RHOA Proteine) and Wnt5a/Ror2 (zeige ROR2 Proteine) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (zeige RSPO3 Proteine) binds syndecan 4 and that together they activate Wnt5a/PCP (zeige PRCP Proteine) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (zeige SDC4 Proteine) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (zeige PCDH8 Proteine) by XWnt-5A requires the receptor tyrosine kinase Ror2 (zeige ROR2 Proteine).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (zeige WNT2 Proteine)/JNK (zeige MAPK8 Proteine) signaling
WNT5A is a negative regulator of FSH (zeige BRD2 Proteine)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Wnt5a promotes IL-6 (zeige IL6 Proteine) and TIMP-1 (zeige TIMP1 Proteine) release from mouse cardiac fibroblasts.
WNT5A promoted spermatogonial stem cells activity both in vitro and in vivo.
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (zeige TGFB1 Proteine) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (zeige WNT5B Proteine) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (zeige FGF10 Proteine) and Ihh (zeige IHH Proteine).
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5