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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
Study shows that Wnt5a is upregulated in invasive glioblastoma tissues, and demonstrates that it may regulate the invasion of glioblastoma cells, at least in part via the Daam1 (zeige DAAM1 Proteine)/RhoA (zeige RHOA Proteine) signaling pathway.
The findings suggest that Wnt5a expression may be involved in the inhibition of cell differentiation and the induction of an inflammatory response.
High WNT5A expression is associated with gliomas
Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer, which is involved in the activation of beta-catenin (zeige CTNNB1 Proteine)-dependent canonical Wnt (zeige WNT2 Proteine) signaling.
This study suggests that methylation of Wnt (zeige WNT2 Proteine) pathway genes, in addition to known CpG island methylator phenotype markers, may help predict treatment outcome and survival in patients with CRC (zeige CALR Proteine)[colorectal cancer.
non-canonical Wnt5a signalling could play a role in early human trophoblast development by promoting cell proliferation and survival.
These findings suggest that WNT-5A modulates fundamental mechanisms that affect airway smooth muscle contraction and thus may be of relevance for airway hyperresponsiveness in asthma.
We performed immunohistochemistry for Ki67 (zeige MKI67 Proteine), p16INK4a, and WNT5A in human HPs (zeige HPS1 Proteine) ( hyperplastic polyps), sessile serrated adenomas/polyps (SSA (zeige TRIM21 Proteine)/Ps), and traditional serrated adenomas (TSAs) .The distribution of Ki67 (zeige MKI67 Proteine) and p16INK4a positive cells in TSAs was different from that in HPs (zeige HPS1 Proteine) and SSA (zeige TRIM21 Proteine)/Ps.
Wnt5a-Ror2 (zeige ROR2 Proteine) signaling enhanced tongue SCC (zeige CYP11A1 Proteine) cell aggressiveness and promoted production of MMP-2 (zeige MMP2 Proteine) following DeltaNp63beta-mediated EMT (zeige ITK Proteine)
Here, the authors define WNT5A, a non-canonical Wnt (zeige WNT2 Proteine) ligand implicated in epithelial differentiation, repair, and cancer, as a direct transcriptional target that is activated by KLF4 (zeige KLF4 Proteine) in squamous epithelial cells.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (zeige WNT3A Proteine), acted across many cell diameters to orient Prickle3 (zeige PRICKLE3 Proteine)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (zeige ROR2 Proteine), which require Wnt5a/Ror2 (zeige ROR2 Proteine) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (zeige PCDH8 Proteine) signaling via RhoA (zeige RHOA Proteine) and Wnt5a/Ror2 (zeige ROR2 Proteine) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (zeige RSPO3 Proteine) binds syndecan 4 and that together they activate Wnt5a/PCP (zeige PRCP Proteine) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (zeige SDC4 Proteine) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (zeige PCDH8 Proteine) by XWnt-5A requires the receptor tyrosine kinase Ror2 (zeige ROR2 Proteine).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (zeige WNT2 Proteine)/JNK (zeige MAPK8 Proteine) signaling
WNT5A is a negative regulator of FSH (zeige BRD2 Proteine)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Activating effect of WNT5A regulated bone formation in response to hindlimb unloading in mice, and pretreatment with WNT5A partly rescued the osteoporosis caused by mechanical unloading.
The results of this study indicated that Shh (zeige SHH Proteine), Sfrp1 (zeige SFRP1 Proteine), and Wnt5a collaborate to direct the pathfinding of descending 5-HT (zeige DDC Proteine) axons in the brainstem.
calcineurin is a key regulator of Wnt5a-induced AQP2 (zeige AQP2 Proteine) activation without affecting intracellular cAMP level and PKA activity.
The findings demonstrate that induction of Vangl protein phosphorylation plays an essential role in transducing Wnt5a signaling to establish Planar cell polarity (PCP (zeige BMP1 Proteine)) in mammalian development, suggesting a phosphorylation-regulated (zeige PHAX Proteine) "Vangl activity gradient" model in addition to the well-documented "Fz activity gradient" model in Wnt (zeige WNT2 Proteine)/PCP (zeige BMP1 Proteine) signaling.
Post-mitotic filopodial "pathfinding" is guided by mesenchymal WNT5A. Without WNT5A, some cells fail to tether basally and undergo apoptosis, leading to a shortened midgut.
We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP (zeige BMP1 Proteine)) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 (zeige FGF4 Proteine) and Fgf8 (zeige FGF8 Proteine) signaling to orient PCP (zeige BMP1 Proteine).
Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
These data suggest that Wnt5a modulates the development of arthritis by promoting inflammation and osteoclast fusion, and provide the first mouse genetic evidence of a role for endogenous Wnt5a in autoimmune disease.
Here, we show that deletion of a single Wnt (zeige WNT2 Proteine) family member, Wnt5a, is sufficient to elicit profound disruptions in synaptic plasticity, structural maintenance, and learning and memory in adult mice, identifying the importance of this particular noncanonical Wnt (zeige WNT2 Proteine) in later-life functions.
Wnt5a promotes IL-6 (zeige IL6 Proteine) and TIMP-1 (zeige TIMP1 Proteine) release from mouse cardiac fibroblasts.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5