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disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.
Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila
dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.
DWnt4 antagonizes the polarizing effect of four-jointed
in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina
Wnt4 and Wnt11 (zeige WNT11 Proteine) cooperatively contribute to mammalian neuromuscular junction formation.
GLP-1 (zeige GCG Proteine) promoted adipogenesis through the modulation of the Wnt4/beta-catenin (zeige CTNNB1 Proteine) signaling pathway
Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development.
Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis
Data indicate that a balance between supporting cell (zeige PTPRJ Proteine) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin (zeige CTNNB1 Proteine) and p27Kip1 (zeige CDKN1B Proteine) protein (p27 (zeige CDKN1B Proteine))/Forkhead box L2 (FOXL2 (zeige FOXL2 Proteine)) activities.
decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.
Mir (zeige MLXIP Proteine)-29c regulates WNT4 signaling.
Wnt4 is essential to normal mammalian lung development.
RSPO1 (zeige RSPO1 Proteine), WNT4, and beta-catenin (zeige CTNNB1 Proteine) have roles in the signaling pathway during ovarian differentiation in mice.
The Runx-1 (zeige RUNX1 Proteine) gene can be a Wnt-4 signalling target, and that Runx-1 (zeige RUNX1 Proteine) and Wnt-4 are mutually interdependent in their expression.
were not able to replicate or further verify the genetic association of polymorphisms in WNT4 and WNT5B (zeige WNT5B Proteine) with bone mineral density
These findings demonstrate that autocrine human growth hormone (zeige GH1 Proteine) regulates WNT4 expression and that WNT4 is a potential therapeutic target in human breast cancer.
WNT4 encodes wingless-type MMTV integration site family member 4. WNT4 mutations have been found in women with mullerian duct abnormalities, primary amenorrhea, and hyperandrogenism and common variants in WNT4, which are in high linkage disequilibrium with our index SNPs, are associated with endometriosis, ovarian cancer,and bone mineral density of WNT4, and the T allele generates a strong ESR1 (zeige ESR1 Proteine)-binding site.
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B (zeige HNF1B Proteine), and LHX1 (zeige LHX1 Proteine) point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
WNT4 drives a novel signaling pathway in ILC (zeige CCL27 Proteine) cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. WNT4 signaling may represent a novel target to modulate endocrine response specifically for patients with ILC (zeige CCL27 Proteine).
The etiology of MRKH syndrome is still largely unknown, probably because of its intrinsic heterogeneity. Several candidate causative genes have been investigated, but to date only WNT4 has been associated with MRKH with hyperandrogenism. This review summarizes and discusses the clinical features and details progress to date in understanding the genetics of MRKH syndrome.
We highlight the cooperation of WNT4, RSPO1 (zeige RSPO1 Proteine) and FOXL2 (zeige FOXL2 Proteine) within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
The WNT4 expression level in eutopic endometrium was significantly reduced compared with that in normal endometrium of the control group.
Studied the roles of WNT4 and WNT5A (zeige WNT5A Proteine) in human decidulization and their relationship with preeclampsia.
identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes
XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development
Study shows that Wnt-4 acts through the Notch (zeige NOTCH1 Proteine) effector gene hrt1 (zeige HEY1 Proteine) by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.
single inhibition of melatonin receptor 1 or Wnt-4 expression decreased expression of neurogenesis-related genes, and bovine amniotic epithelial cell-derived neural cells were successfully colonized into injured spinal cord, which suggested participation in tissue repair.
Data show that in vivo, wnt11r (zeige WNT11 Proteine) and wnt4a initiate MuSK (zeige MUSK Proteine) translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (zeige WNT2 Proteine) signaling inhibitor, Dkk (zeige DKK1 Proteine), and induced expression of the Wnt (zeige WNT2 Proteine) ligand, Wnt4a.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
three Wnt (zeige WNT2 Proteine) noncanonical ligands wnt4a, silberblick/wnt11 (zeige WNT11 Proteine), and wnt11 (zeige WNT11 Proteine)-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
, wingless-type MMTV integration site family, member 4
, protein Wnt-4
, signal molecule
, wingless-related MMTV integration site 4
, Wnt-4 protein
, protein Wnt-4a