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Human WNT3 Protein expressed in Wheat germ - ABIN1325359
Kraushar, Viljetic, Wijeratne, Thompson, Jiao, Pike, Medvedeva, Groszer, Kiledjian, Hart, Rasin: Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Demonstrate a significant change in miRNA profile dependent on the assisted reproductive technology outcome affecting Wnt pathway.
High expression of WNT3 is associated with hepatocellular carcinoma.
Our data demonstrated an important interdependence between TGF-beta and Wnt/beta-catenin pathways inducing EMT in HER2-overexpressing breast cancer cells. Twist served as a linkage between the two pathways during TGF-beta-induced EMT. A83-01 could inhibit the TGF-beta-initiated pathway interactions and enhance HER2-cells response to trastuzumab treatment
YAP maintains human embryonic stem cells pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation.
Wnt3 is associated with cholesterol-dependent domains
analysis of WNT3 expression in CLL patients demonstrated that (i) untreated patients with more aggressive disease (with a notable exception of patients with 11q deletion) express less WNT3, (ii) WNT3 declines with disease progression in a significant proportion of patients and (iii) low WNT3 was identified as a strong independent marker indicating shorter treatment-free survival in CLL patients with IGHV mutation.
PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
Two SNPs (rs3809857 and rs9890413) in the WNT3 gene were subjected to case-control and case-parent analysis
WNT3 and membrane-associated beta-catenin regulate trophectoderm lineage differentiation in human blastocysts.
WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish
Genome association study shows a highly conserved 32 kb intergenic region containing regulatory elements between WNT3 and WNT9B in patients with classic bladder exstrophy.
mRNA level of WNT3 in hESCs correlates with their definitive ectoderm differentiation efficiency.
Data show that the WNT/beta-CATENIN signaling cascade components, including WNT ligands WNT3 and WNT5A, is crucial for early odontogenesis.
WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.
Colorectal tumors express elevated levels of Wnt3 and GPR177.
WNT3 and WNT5B are critical factors, secreted from mesenchymal cancer cells, for instigating the epithelial cancer cell invasion.
Knockdown of Wnt3 by siRNA restored cytoplasmic expression of beta-catenin.
The apoptotic index was significantly lower in high-Wnt3 tumors than in low-Wnt3 tumors (P=0.0245).
study confirmed the involvement of polymorphisms in the WNT3 gene in NCL/P aetiology in the tested population.
The findings of a significant association between lip and/or palate clefts and two markers in the WNT3 and COL11A2 genes were the most consistent and were observed in all groups analysed and stratified.
Data suggest that Wnt3, Wnt3a, and Wnt8a bind to their respective receptors (Fz8, Lrp6, and Lypd6) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt proteins to their receptor complexes and stimulation of downstream signaling activity.
Study demonstrates that Wnt3 regulates cerebellum development during embryogenesis using zebrafish wnt3 transgenics with either tissue-specific expression of an EGFP reporter or a functionally active fusion protein, Wnt3EGFP.
We have identified canonical Wnt signaling as a novel pathway, that is required for proper formation of the mid-diencephalic organizer and consequently for the development of the major relay station of the brain - the thalamus.
Wnt3 participates in processes such as forebrain compartmentalization and regulation of tectal wiring topography by retinal ganglia axons.
Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in dorsal root ganglion neurons.
Here, we describe the culture protocol using Wnt-3a for successful maintenance of skin epithelial stem cells .
Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant.
these results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs.
stem-cell membranes constitute a reservoir for Wnt proteins, while Frizzled receptor turnover and 'plasma membrane dilution' through cell division shape the epithelial Wnt3 gradient
timed secretion of wnt3 by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex. WNT3 further regulates the specificity of mRNA translation and development of neurons and oligodendrocytes.
this article shows that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak
Data indicate that functional Wnt3/beta-Catenin signaling is localized to the dorsal subventricular zone (SVZ) microdomain.
Wnt3 is part of a signaling loop that affects homeostasis of intestinal stem and Paneth cells in mice.
Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice
These results suggest that the regulation of paracrine factors plays a critical role in hippocampal aging and neurogenesis.
canonical Wnt signaling regulates CXCL12 gene expression at the transcriptional level
Wnt-3a and Wnt-3 factors signal through the canonical Wnt/beta-catenin pathway to regulate different aspects of spinal cord neural progenitor development.
The mRNA levels of Wnt3, 6, and 9a were significantly upregulated in the intestinal epithelial cells by Salmonella.
Different permissive Wnt3/beta-catenin signaling thresholds is required for the embryonic development of head structures and adult intestinal polyposis.
Wnt3a stimulates Src docking to Dvl2 and activation of Src.
WNT-3, expressed by motor neurons, acts as a retrograde signal that controls terminal arborization of muscle afferents.
Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.
Expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm
effects of Wnt3a are exerted through activation of the beta-catenin signal transduction pathway and do not require alternative Wnt transduction cascades
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
WNT-3 proto-oncogene protein
, proto-oncogene Int-4 homolog
, proto-oncogene Wnt-3
, Wingless-type MMTV integration site 3, homolog
, wingless-related MMTV integration site 3
, wingless-type MMTV integration site family member 3
, wingless-type MMTV integration site family, member 3
, wingless-related MMTV integration site 3A
, proto-oncogene Wnt-3-like
, proto-oncogene Int-4
, proto-oncogene protein Wnt-3
, Xwnt-3 region near C-terminus