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Rspo1 (zeige RSPO1 Proteine) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (zeige FUT1 Proteine) specification: Wnt16/DeltaC/DeltaD and Vegfa (zeige VEGFA Proteine)/Tgfbeta1 (zeige TGFB1 Proteine)
Wnt16 controls a novel genetic regulatory network required for HSC (zeige FUT1 Proteine) specification
genomic analysis of conserved sequences between human, rat, and zebrafish WNT16
that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength
WNT16 antagonises excessive canonical WNT (zeige WNT2 Proteine) activation and protects cartilage in osteoarthritis.
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
Describe TGFbeta (zeige TGFB1 Proteine)-Wnt16-Notch (zeige NOTCH1 Proteine) signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta (zeige TGFB1 Proteine) activity in MGP (zeige MGP Proteine)-null VSMCs as a critical mediator of chondrogenesis.
Wnt5a (zeige WNT5A Proteine) abrogated the inhibitory effects of Wnt16 on Rankl (zeige TNFSF11 Proteine)-induced osteoclastogenesis
These findings suggest that WNT16 acting via canonical WNT (zeige WNT2 Proteine) signaling regulates mechanical strain-induced periosteal bone formation and bone size.
Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility.
Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
Study revealed new domains of expression for Wnt2 (zeige WNT2 Proteine), Wnt2b (zeige WNT2B Proteine), Wnt5b (zeige WNT5B Proteine), Wnt6 (zeige WNT6 Proteine), Wnt7b (zeige WNT7B Proteine), Wnt9a (zeige WNT9A Proteine), Wnt10a (zeige WNT10A Proteine), Wnt10b (zeige WNT10B Proteine), Wnt11 (zeige WNT11 Proteine) and Wnt16, in the limb.
WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3 (zeige FZD3 Proteine)/4/6, a process enhanced by SFRP2 (zeige SFRP2 Proteine), coordinated by the co-receptor LRP6 (zeige LRP6 Proteine) but subject to abrogation by DKK1 (zeige DKK1 Proteine).
the upregulation of autophagy-related gene (Atg) and wingless/int1 (zeige WNT1 Proteine) (Wnt (zeige WNT2 Proteine)) signaling during BMP-2 (zeige BMP2 Proteine)-mediated human osteoblastic differentiation, was examined.
PRKX (zeige PRKX Proteine), WNT3 (zeige WNT3 Proteine) and WNT16 genes, belonging to the WNT (zeige WNT2 Proteine) signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma
ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition.
Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA (zeige IDUA Proteine) and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein.
MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 (zeige AKT1 Proteine) and Wnt-16
Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content.
ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine.
loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
wingless-type MMTV integration site family, member 16
, protein Wnt-16
, protein Wnt-16-like
, wingless-type MMTV integration site family member 16
, wingless-type MMTV integration site family member 16b
, wingless-related MMTV integration site 16