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Wnt10b recruitment to lipid rafts and mTOR (zeige FRAP1 Proteine) activation promotes regeneration of injured optic nerve.
We examined a new culture condition for DPCs including addition of Wnt (zeige WNT2 Proteine)-10b, which promoted proliferation and maintained their HF induction ability for more than ten passages. These results suggest that Wnt (zeige WNT2 Proteine)-10b plays a pivotal role in proliferation and maintenance of DPCs in vitro
Wnt10b expression was assessed by flow cytometry under estrogen- and TNFalpha (zeige TNF Proteine)-deficient conditions.
AT2R (zeige AGTR2 Proteine) inhibits adipogenic differentiation in mesenchymal stem cells. Moreover, this inhibitory effect is associated with Wnt10b/beta-catenin (zeige CTNNB1 Proteine) signaling.
XBP1s can regulate Wnt10b by a post-transcriptional mechanism through directly inducing microRNA-148a.
findings suggest that Wnt10b plays an important role in regulating asthmatic airway inflammation through modification of the T cell response and is a prospective target in the disease process
Data show that Wnt protein Wnt10b is expressed in cardiomyocytes and localized in the intercalated discs of mouse and human hearts.
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin (zeige GAL Proteine)-mediated signaling cascades.
results suggest that Wnt (zeige WNT2 Proteine)-10b represses tumor cell properties, such as proliferation and migration of B16 melanoma cells, driving them toward a more differentiated state along a melanocyte lineage
Wnt10b/DKK1 (zeige DKK1 Proteine) can modulate hair follicle size during hair regeneration.
Wnt10b is involved in forskolin/hCG (zeige CGA Proteine)-mediated BeWo cell fusion via beta-catenin (zeige CTNNB1 Proteine)/GCMa (zeige GCM1 Proteine)/syncytin (zeige ERVW-1 Proteine) pathway, which may also involve activation of PKA
These results present the first evidence for a recurrent rearrangement promoted by a mobile ht-WNT10B oncogene (zeige RAB1A Proteine), as a relevant mechanism for Wnt (zeige WNT2 Proteine) involvement in human cancer.
High expression of WNT10B is associated with epithelial-mesenchymal transition and invasion of pancreatic cancer.
this study provides novel insight into the mechanism of action of parathyroid hormone (zeige PTH Proteine) on human periodontal ligament cells and establish their interplay with T cells via the Wnt10b pathway as a modulating factor for the anabolic properties of the hormone in periodontal regeneration
findings provide the identification of autosomal-dominant WNT10B mutations in individuals with oligodontia, which increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt (zeige WNT2 Proteine) signaling in endothelial differentiation of dental pulp stem cells.
these findings clearly demonstrate that Wnt10b promotes epidermal keratinocyte transformation through induced Egf (zeige EGF Proteine) pathway
WNT10B enhances proliferation through beta-catenin (zeige CTNNB1 Proteine) and RAC1 GTPase (zeige RACGAP1 Proteine) in human corneal endothelial cells.
Sequence analysis of WNT10B gene revealed a novel 4-bp deletion mutation.
No association between WNT10B polymorphisms and adiposity parameters was found. However, a role for WNT10B variants in determining human bone mineral density was found.
Results indicate that the porcine WNT10B gene may be a very important candidate gene for porcine backfat thickness.
wnt1 (zeige WNT1 Proteine) and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 (zeige FGF8 Proteine) at the midbrain-hindbrain boundary.
In zebrafish embryos lacking Wnt3a (zeige WNT3A Proteine), Wnt1 (zeige WNT1 Proteine) and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 (zeige FGF8 Proteine) is not maintained after mid-somitogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.
wingless-type MMTV integration site family, member 10B
, protein Wnt-10b
, WNT-10B protein
, wingless related MMTV integration site 10b
, Protein Wnt-10
, wnt-1 related (wnt-10), wingless-type MMTV integration site family