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Human WNT1 Protein expressed in Escherichia coli (E. coli) - ABIN413893
Tawk, Makoukji, Belle, Fonte, Trousson, Hawkins, Li, Ghandour, Schumacher, Massaad: Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Show all 2 Pubmed References
maternal Wnt (zeige WNT2 Proteine)/STOP signaling, but not beta-catenin (zeige CTNNB1 Proteine) signaling, has a role in cleavage after fertilization and cell cycle progression
sfrp1 (zeige SFRP1 Proteine) promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt (zeige WNT2 Proteine) signalling.
analysis of differential role of Axin (zeige AXIN1 Proteine) RGS (zeige PITX2 Proteine) domain function in Wnt (zeige WNT2 Proteine) signaling during anteroposterior patterning and maternal axis formation
Data show taht combined Wnt (zeige WNT2 Proteine) and Nodal signaling synergistically activates transcription of Spemann organizer genes.
The authors propose that these dual functions of DP1 (zeige TFDP1 Proteine) can promote and stabilize biphasic Wnt (zeige WNT2 Proteine)-on and Wnt (zeige WNT2 Proteine)-off states in response to a gradual gradient of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling to determine differential cell fates.
These data suggested that Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway might be a potential target to treat the LPS (zeige TLR4 Proteine)-induced inflammation in ALI.
Wnt (zeige WNT2 Proteine) signaling regulates airway epithelial stem cells in adult murine submucosal glands.
Pax9 (zeige PAX9 Proteine)-dependent Wnt (zeige WNT2 Proteine) signaling has a role in palatogenesis and cleft palates
Data show that autocrine Wnt (zeige WNT2 Proteine) secretion is important for the survival, chromosomal stability, differentiation, and tumorigenic potential of embryonic stem cells (ESCs (zeige NR2E3 Proteine)).
Results demonstrated functional differences in the molecular mechanisms downstream of Wnt1 function in the diencephalon, in relation to the spinal cord. Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis
Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin (zeige CTNNB1 Proteine) in the neural crest.
data suggest that WNT1-related osteogenesis imperfecta (zeige COL1A2 Proteine) and osteoporosis are caused in part by decreased mTORC1-dependent osteoblast function resulting from loss of WNT1 signaling in osteocytes.
Administration of EET alters Wnt1, NOV (zeige NOV Proteine), and HO-1 (zeige HMOX1 Proteine) signaling to prevent obesity-induced cardiomyopathy in obese mice.
Data indicate that Wnt1 proto-oncogene (zeige RAB1A Proteine) protein (WNT1) is the direct target of microRNA miR (zeige MLXIP Proteine)-34a in dendritic cell (DC).
In order to evaluate the function of IFT88 (zeige IFT88 Proteine) in regulating craniofacial development, we generated Wnt1-Cre;Ift88fl/fl mice to eliminate Ift88 (zeige IFT88 Proteine) specifically in cranial neural crest (CNC) cells. Wnt1-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme
Biallelic pathogenic splice acceptor site variant (c.359-3C>G) in WNT1 gene located on chromosome 12q13.12 underlying osteogenesis imperfecta (zeige COL1A2 Proteine) type 3 in a Pakistani family.
Vertebral compression fractures were present in 78% (7/9) of those aged over 50years but were not seen in younger mutation-positive subjects. All those with fractures had several severely compressed vertebrae. Altogether spinal compression fractures were present in 39% of those with a WNT1 mutation. Only
miR (zeige MLXIP Proteine)-218 promoted the apoptosis of human ovarian carcinoma cells via suppression of the WNT (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.
Data suggest that brain imaging be performed in any individual with WNT1-associated osteogenesis imperfecta (zeige COL1A2 Proteine) (OI) who also has developmental delay or any neurological deficits.
Data indicate a tetracyclic azafluorenone, SJ26, that is capable of binding to G-quadruplex DNA structure, repressing WNT1 expression, and inhibiting cell migration.
Regulation of WNT (zeige WNT2 Proteine) signaling by VSX2 (zeige VSX2 Proteine) during optic vesicle patterning in human induced pluripotent stem cells has been described.
High WNT1 expression is associated with metastasis in triple-negative breast cancer.
WNT1 osteoporosis causes significant skeletal changes already in early childhood and impairs bone mass gain during pubertal years.
High WNT1 expression is associated with esophageal squamous cell carcinoma.
High WNT1 expression in stromal cells is associated with myelodysplastic syndrome.
Data indicate that Wnt-1 protein is present in postdevelopmental endothelial cells where it associates with cytoskeletal elements and may retain function as a tissue polarity gene.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
wnt1 and wnt10b (zeige WNT10B Proteine) are required to maintain threshold levels of Pax2.1 and Fgf8 (zeige FGF8 Proteine) at the midbrain-hindbrain boundary.
novel role for Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling in determining endocardial cell fate
In zebrafish embryos lacking Wnt3a (zeige WNT3A Proteine), Wnt1 and Wnt10b (zeige WNT10B Proteine), the expression of engrailed orthologs, pax2a and fgf8 (zeige FGF8 Proteine) is not maintained after mid-somitogenesis
two Dvl (zeige DVL2 Proteine)-associated paralogs, Dpr1 (zeige DACT1 Proteine) and Dpr2 (zeige DACT2 Proteine), participate in distinct Wnt (zeige WNT2 Proteine)-dependent developmental processes
Wnt (zeige WNT2 Proteine)/Axin (zeige AXIN1 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway has a role in ventral CNS development
The boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions.
Epistatic analyses suggest a possible genetic interaction between Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and Myostatin (zeige MSTN Proteine) in regulation of slow and fast twitch muscle myofibrillogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
, protein Wnt-1
, proto-oncogene Int-1
, proto-oncogene Wnt-1
, proto-oncogene protein Wnt-1
, proto-oncogene Int-1 homolog
, wingless-type MMTV integration site family, member 1 (oncogene INT1)
, Wingless-type MMTV integration site 1 homolog
, Wingless-type MMTV integration site 1, homolog
, wingless-related MMTV integration site 1
, murine mammary tumor virus integration site
, wingless-type MMTV integration site family member 1