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Human WIF1 Protein expressed in Wheat germ - ABIN1325330
Kansara, Tsang, Kodjabachian, Sims, Trivett, Ehrich, Dobrovic, Slavin, Choong, Simmons, Dawid, Thomas: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. in The Journal of clinical investigation 2009
We identify a loss-of-function mutation in WIF1 (NM_007191 p.W15*), which is involved in mesoderm segmentation, as the suspected cause of the Nail (zeige CD244 Proteine)-Patella-like disorder observed in this family.
the results of our study show that down-regulated INTS6 (zeige INTS6 Proteine) expression is associated with a poorer prognosis in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients. This newly identified INTS6 (zeige INTS6 Proteine)/WIF-1 axis indicates the molecular mechanism of HCC (zeige FAM126A Proteine) and may represent a therapeutic target in HCC (zeige FAM126A Proteine) patients.
the promoters of WIF1, NLK (zeige NLK Proteine), and APC (zeige APC Proteine) are highly methylated in the nasopharyngeal cancers (NPC (zeige NPC1 Proteine)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (zeige MLXIP Proteine)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1, APC (zeige APC Proteine), and NLK (zeige NLK Proteine) genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (zeige MLXIP Proteine)-BART19-3p
Data show the frequency of WIF-1 hypermethylation significantly increased in non-small cell lung cancer (NSCLC) specimens compared with normal lung tissue. WIF-1 hypermethylation is predominant in squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)), suggesting that WIF-1 methylation contributes to the development of NSCLC, especially SCC (zeige CYP11A1 Proteine). [review]
Study supported the hypothesis that Wnt inhibitory factor 1 (WIF1) is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis.
Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (zeige SFRP1 Proteine) and Wnt inhibitory factor 1, and a significant increase in cell death after tyrosine kinase (zeige TXK Proteine) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (zeige SFRP1 Proteine) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (zeige TXK Proteine) inhibitors.
Gallbladder cancer patients with hypermethylated WIF-1 exhibited worse overall survival than those with hypomethylated WIF-1.
In astrocytoma specimens, tumor areas with numerous single cells were identified which strongly express Wif-1.
Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y (zeige NPY Proteine)) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
the expression levels of WIF-1 were low in gallbladder cancer tumor tissues and the GBC-SD, SGC (zeige SGCB Proteine)-996 and NOZ gallbladder cancer cell lines. This low expression was associated with the methylation status of the WIF-1 gene promotor.
Wif1 localizes to the enamel knot in which Wif1 regulates apoptosis by mediating and regulating Wnt (zeige WNT2 Proteine)-beta-catenin (zeige CTNNB1 Proteine) signaling. Thus, Wif1 plays an essential role in tooth development.
WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin
results demonstrate that Wif1 is not targeted for silencing by DNA methylation (zeige HELLS Proteine) in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation
EZH2 (zeige EZH2 Proteine)-induced downregulation of WIF1 expression may partially regulate Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine)-dependent crypt hyperplasia in response to citrobacter rodentium infection
Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis.
It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases
WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males
These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism.
Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential.
In an examination of signaling pathways in developing Xenopus lung, wif1 was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Data describe the importance of proper level of Wnt (zeige WNT2 Proteine) signaling for normal development of swimbladder in Wif1 morphant zebrafish.
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
, wnt inhibitory factor 1
, WNT inhibitory factor 1
, wnt inhibitory factor 1-like
, Wnt inhibitory factor-1
, wnt inhibitory factor-1