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loss of Llgl1 results in EGFR (zeige EGFR Proteine) mislocalization, promoting pre-neoplastic changes
these results revealed that miR (zeige MLXIP Proteine)-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 (zeige CRISPLD2 Proteine)
Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2 (zeige CNTNAP2 Proteine)-IgG or LGI1 (zeige LGI1 Proteine)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (zeige LGI1 Proteine)-IgG.
Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage.
Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent.
this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy.
Lgl1 (zeige CRISPLD2 Proteine) has a role in inhibiting glioblastoma
PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C (zeige PRKCZ Proteine) in glioblastoma cells.
Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo.
inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia (zeige BCL11A Proteine)
Ablation of Llgl1 gene Results in Severe Brain Malformation.
Lgl1 (zeige Klra7 Proteine) is required for the development of the olfactory bulb.
results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1 (zeige Klra7 Proteine)-dependent global and cell intrinsic mechanisms.
These results reveal a novel role for Lgl-1 (zeige Klra7 Proteine) in the regulation of virus-specific T-cell responses and antitumor immunity.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (zeige Klra7 Proteine))-Pax2 (zeige PAX2 Proteine) protein knockout embryos.
Lgl1 (zeige Klra7 Proteine) forms two distinct complexes in vivo, Lgl1 (zeige Klra7 Proteine)-NMIIA and Lgl1 (zeige Klra7 Proteine)-Par6alpha (zeige PARD6A Proteine)-aPKCzeta (zeige PRKCZ Proteine), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (zeige Klra7 Proteine).
Collectively these findings indicate that Lgl1 (zeige Klra7 Proteine) regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
This is the first study to demonstrate the involvement of Dlg1 (zeige DLG1 Proteine), Scrib, and Lgl1 (zeige Klra7 Proteine) in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut (zeige GUSB Proteine)
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
disks large homolog 4
, lethal(2) giant larvae protein homolog 1
, human homolog to the D-lgl gene protein