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Human LEF1 Protein expressed in Wheat germ - ABIN1309292
Shimomura, Takasaki, Nomura, Hayashi, Senda: Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. in Medical molecular morphology 2013
Data suggest that LEF1-dependent genes in zebrafish hypothalamus are associated with anxiety; LEF1 null mutant zebrafish exhibit increased anxiety.
mesodermal Wnt3a (zeige WNT3A Proteine)-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (zeige GATA1 Proteine) expression) in zebrafish embryos.
Amotl2a (zeige AMOTL2 Proteine) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (zeige YAP1 Proteine) and the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) effector Lef1.
Lef1 has a role in regulating Dusp6 (zeige DUSP6 Proteine) in formation of the zebrafish posterior lateral line primordium
Nlk2 (zeige NLK Proteine) is essential for the phosphorylation and activation of Lef1 transcriptional activity in neural progenitor cells.
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast deposition rate.
Data conclude that lef1-mediated Wnt (zeige WNT2 Proteine) signaling is involved in various aspects of primordium migration, although part of this implication is masked by a high level of developmental redundancy.
Data show cooperation between Dnmt3 and an H3K9 methyltransferase G9a (zeige EHMT2 Proteine) in regulating lef1.
high-affinity binding sites for Tcf (zeige HNF4A Proteine)/Lef1 within the boz promoter region
Lef1 and Tcf1 (zeige HNF1A Proteine) showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
Data (including data from studies using transgenic/knockout mice) suggest that expression of Lef1 in hypothalamus inhibits anxiety and regulates neurogenesis; expression of Lef1 in hypothalamus is required for neurogenesis.
Uncovering a Pitx2 (zeige PITX2 Proteine)-Sox2 (zeige SOX2 Proteine)-Lef-1 transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
this study shows that the transcription factors Tcf1 (zeige HNF1A Proteine) and Lef1 suppress CD4 (zeige CD4 Proteine)+ T lineage genes in CD8 (zeige CD8A Proteine)+ T cells through intrinsic histone deacetylase (zeige HDAC1 Proteine) activity
leukemic stem cells are therefore more sensitive to loss of Tcf1 (zeige HNF1A Proteine) and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity.
Sp5 (zeige SP5 Proteine)/8 bind directly to GC boxes in Wnt (zeige WNT2 Proteine) target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1 (zeige HNF1A Proteine)/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin (zeige CTNNB1 Proteine) to target gene enhancers.
This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 (zeige HNF1A Proteine) and LEF1 for the development of all subsets of Natural Killer T cells.
this study gives new insights into transcriptional regulating mechanisms of Wnt (zeige WNT2 Proteine)-mediated Isl1 (zeige ISL1 Proteine) expression during cardiomyocyte differentiation.
data reveal LEF1 as a central regulator of iNKT cell number and Th2-type effector differentiation.
These findings provide evidence for the existance of a posititve feedback loop connecting survivin (zeige BIRC5 Proteine) expression in tumor cells to PI3K/Akt (zeige AKT1 Proteine) enhanced beta-catenin (zeige CTNNB1 Proteine)-Tcf (zeige HNF4A Proteine)/Lef-dependent transcription followed by secretion of VEGF (zeige VEGFA Proteine) and angiogenesis.
Tcf (zeige HNF4A Proteine)/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling and to trigger tissue-specific responses.
Interaction of Xom and LEF1/TCF (zeige HNF4A Proteine)-factors is essential for ventral cell fate determination and LEF1/TCF (zeige HNF4A Proteine) factors may function as a point of convergence to mediate the combined signaling of Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and BMP4 (zeige BMP4 Proteine)/Xom pathways during early embryogenesis.
these data suggest that LEF1 rather has tumor suppressive functions and attenuates aggressiveness in a subset of RMS.
Positive LEF-1 favors a benign neoplasm.
Results show that high enhancer-binding factor-1 (LEF1) expression is associated with poor survival for chronic lymphocytic leukemia (CLL) patients.
Knockdown of GATA6 (zeige GATA6 Proteine) completely eliminated the effect of TCF1 (zeige HNF1A Proteine), while forced expression of GATA6 (zeige GATA6 Proteine) induced hESC differentiation
Data indicate that microRNA miR (zeige MLXIP Proteine)-27a directly targets GSK-3beta and increases expression of beta-catenin (zeige CTNNB1 Proteine) and LEF1 in all-trans-retinoic acid (ATRA)-induced Hep2 cells.
and CTU1 (zeige CTU1 Proteine)/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio (zeige ACAA1 Proteine) tRNA modification, are up-regulated in human breast cancers and sustain metastasis.
EVI1 (zeige MECOM Proteine) transcription is directly regulated by LEF1/beta-catenin (zeige CTNNB1 Proteine) complex in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A Proteine). Loss of p53 (zeige TP53 Proteine) function as a key regulator for beta-catenin (zeige CTNNB1 Proteine)-EVI1 (zeige MECOM Proteine) in myeloid blast crisis of chronic myeloid leukemia (zeige BCL11A Proteine).
LEF1 is a sensitive and specific marker for chronic lymphocytic B-cell leukemia
a frequency of 4-9% expression of LEF1 bymantle cell lymphoma
The molecular characterisation of the porcine LEF1 gene and its association with number of teats and inverted teats in experimental and commercial populations, is described.
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
lymphoid enhancer binding factor-1
, lymphoid enhancer-binding factor 1
, lymphoid enhancer-binding factor 1-like
, lymphoid enhancer binding factor 1 short isoform
, T cell-specific transcription factor 1-alpha
, lymphiod enhancer binding factor 1
, transcription factor LEF-1
, lymphoid enhancer binding factor 1