anti-Hund FZD8 Antikörper für Western Blotting

Recommended FZD8 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Frizzled Family Receptor 8 (FZD8) Antikörper
  • FZ-8
  • hFZ8
  • FZD8
  • Fz-8
  • frizzled8
  • xfz8
  • Xfz8
  • frizzled-8
  • hfz8
  • Fz8
  • fzd8
  • frizzled class receptor 8
  • frizzled class receptor 8 S homeolog
  • frizzled class receptor 8 L homeolog
  • FZD8
  • fzd8.S
  • fzd8
  • Fzd8
  • fzd8.L
Epitop
N-Term
19
13
6
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Hund, Human, Maus, Ratte (Rattus)
64
48
23
7
6
5
3
3
2
2
Wirt
Kaninchen
47
21
17
1
Klonalität
Polyklonal
Konjugat
Dieser FZD8 Antikörper ist unkonjugiert
4
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
62
33
27
24
8
4
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2776728
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
3.2286417 ABIN2562711 IHC ELISA WB Goat IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN297075 ELISA WB Goat AA 684-694 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5553157 IHC (p) WB Goat C-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen Frizzled Family Receptor 8 (FZD8) Antikörper
Epitop N-Term
(19), (13), (6), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Hund, Human, Maus, Ratte (Rattus)
(64), (48), (23), (7), (6), (5), (3), (3), (2), (2)
Wirt Kaninchen
(47), (21), (17), (1)
Klonalität
Polyklonal
Konjugat Dieser FZD8 Antikörper ist unkonjugiert
(4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Western Blotting (WB)
(62), (33), (27), (24), (8), (4), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-FZD8 Antikörper

Target Details FZD8 Anwendungsinformationen Handhabung Referenzen für anti-FZD8 Antikörper (ABIN2776728) Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN977174.
Sequenz PDTLCMDYNR TDLTTAAPSP PRRLPPPPPG EQPPSGSGHG RPPGARPPHR
Homologie Dog: 100%, Human: 100%, Mouse: 93%, Rat: 92%
Produktmerkmale This is a rabbit polyclonal antibody against FZD8. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FZD8

Target Details FZD8

Produktdetails anti-FZD8 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-FZD8 Antikörper (ABIN2776728) Bilder zurück nach oben
Antigen
Andere Bezeichnung FZD8 (FZD8 Antibody Abstract)
Hintergrund FZD8 is a member of the frizzled family. Members of this family are seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Alias Symbols: FZ-8, hFZ8
Protein Interaction Partner: WNT1, LRP5, LRP6, SUMO1, GOPC, RYK,
Protein Size: 694
Molekulargewicht 73 kDa
Gen-ID 8325
NCBI Accession NM_031866, NP_114072
UniProt Q9H461
Pathways WNT Signalweg

Anwendungsinformationen

Produktdetails anti-FZD8 Antikörper Target Details FZD8 Handhabung Referenzen für anti-FZD8 Antikörper (ABIN2776728) Bilder zurück nach oben
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 694 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-FZD8 Antikörper Target Details FZD8 Anwendungsinformationen Referenzen für anti-FZD8 Antikörper (ABIN2776728) Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FZD8 Antikörper (ABIN2776728)

Produktdetails anti-FZD8 Antikörper Target Details FZD8 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Xu, Wen, Liu, Xu, Yang, Liu, Feng, An: "MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8." in: Oncotarget, Vol. 7, Issue 26, pp. 40644-40656, 2016

Yin, Xu, Bonfil, Banerjee, Sarkar, Sethi, Reddy: "Tumor-initiating cells and FZD8 play a major role in drug resistance in triple-negative breast cancer." in: Molecular cancer therapeutics, Vol. 12, Issue 4, pp. 491-8, 2013

Allgemeine Veröffentlichungen

Lu, Yamamoto, Ortega, Baltimore: "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth." in: Cell, Vol. 119, Issue 1, pp. 97-108, 2004

Bilder

Produktdetails anti-FZD8 Antikörper Target Details FZD8 Anwendungsinformationen Handhabung Referenzen für anti-FZD8 Antikörper (ABIN2776728) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Frizzled Family Receptor 8 (FZD8) (N-Term) antibody (ABIN2776728) WB Suggested Anti-FZD8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...