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anti-Human AXIN1 Antikörper:
anti-Mouse (Murine) AXIN1 Antikörper:
anti-Rat (Rattus) AXIN1 Antikörper:
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Green Sea Urchin (Lytechinus variegatus) Polyclonal AXIN1 Primary Antibody für IHC - ABIN965628 : Weitzel, Illies, Byrum, Xu, Wikramanayake, Ettensohn: Differential stability of beta-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled. in Development (Cambridge, England) 2004 (PubMed)
Human Polyclonal AXIN1 Primary Antibody für IHC (p), IHC - ABIN249485 : Zeng, Fagotto, Zhang, Hsu, Vasicek, Perry, Lee, Tilghman, Gumbiner, Costantini: The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. in Cell 1997 (PubMed)
analysis of differential role of Axin RGS (zeige PITX2 Antikörper) domain function in Wnt (zeige WNT2 Antikörper) signaling during anteroposterior patterning and maternal axis formation
APC (zeige APC Antikörper) and Axin are involved in the Wnt (zeige WNT2 Antikörper) pathway
Axin binds directly to the export factor CRM1 (zeige XPO1 Antikörper) in the presence of RanGTP
Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma (zeige MOK Antikörper) in a Chinese population.
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (zeige PTPRK Antikörper)(e1)-RSPO3 (zeige RSPO3 Antikörper)(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (zeige WNT2 Antikörper) blockade by the porcupine (zeige PORCN Antikörper) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (zeige WNT2 Antikörper) pathway inhibitor AXIN1, with consequent protein loss.
role in the formation of degradasomes and degradation of beta-catenin (zeige CTNNB1 Antikörper) induced by the TNKSi G007-LK in colorectal cancer cells
VDR (zeige CYP27B1 Antikörper) is important for the maintenance of physiological level of Axin1
RUNX1 (zeige RUNX1 Antikörper) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.
Mutagenesis and binding studies using the bivalent TNKS (zeige TNKS Antikörper) binding domain of Axin1 demonstrate that only certain ankyrin (zeige ANK Antikörper) repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (zeige TNKS Antikörper) ankyrin (zeige ANK Antikörper) repeat conformations modulated by Axin1 interaction.
LGALS3 (zeige LGALS3 Antikörper) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (zeige WNT2 Antikörper)/ beta-catenin (zeige CTNNB1 Antikörper) pathway in the pathogenesis of colorectal cancer
The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma.
AXIN1 is expressed in meningioma along with APC (zeige APC Antikörper) and E-cadherin (zeige CDH1 Antikörper)
Data show that poly(ADP-ribose) polymerase (PARP (zeige PARP1 Antikörper)) enzyme Tankyrase (TNKS (zeige TNKS Antikörper)) inhibition in colon cancer cells decreases beta-catenin (zeige CTNNB1 Antikörper) signaling at the level of both Axin and APC2.
Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.
Axin1 promotes dendritic spine stabilization through Cdc42 (zeige CDC42 Antikörper)-dependent cytoskeletal reorganization.
Axin1 and Axin2 (zeige AXIN2 Antikörper) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.
Study reports that NRF2 (zeige NFE2L2 Antikörper) participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP (zeige BTRC Antikörper) that is disrupted by WNT-3A (zeige WNT3A Antikörper), a prototypic canonical WNT (zeige WNT2 Antikörper) ligand, and leads to upregulation of the NRF2 (zeige NFE2L2 Antikörper) transcriptional signature.
Smurf1 (zeige SMURF1 Antikörper)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.
results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (zeige PITX2 Antikörper) domain.
an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.
Conditional disruption of Axin1 leads to development of liver tumors in mice.
beta-catenin1 cannot revert the ich (zeige ACE Antikörper) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (zeige PITX2 Antikörper) domain function.
Wnt (zeige WNT2 Antikörper)/Axin/beta-catenin (zeige CTNNB1 Antikörper) pathway has a role in ventral CNS development
Overactivation of Wnt (zeige WNT2 Antikörper)/Axin1/beta-catenin (zeige CTNNB1 Antikörper) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.
A dorsalization pathway that is exerted by Axin/JNK (zeige MAPK8 Antikörper) signaling and its inhibitor Aida (zeige AIDA Antikörper) during vertebrate embryogenesis, is defined.
Dab2 (zeige DAB2 Antikörper) stabilizes Axin and attenuates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling by preventing PP1 from binding Axin
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
axin 1 , axin 1, isoform 1 , axin-1-like , axin-1 , xAxin , axis inhibition protein 1 , axis inhibitor 1 , fused, mouse, homolog of , protein phosphatase 1, regulatory subunit 49 , protein Fused , GSK-3beta interacting protein rAxin , rAxin , masterblind , mbl