anti-AXIN1 (AXIN1) Antikörper

Xenopus laevis Axin 1 (AXIN1) Interaktionspartner

1. analysis of differential role of Axin RGS (zeige PITX2 Antikörper) domain function in Wnt (zeige WNT2 Antikörper) signaling during anteroposterior patterning and maternal axis formation

2. APC (zeige APC Antikörper) and Axin are involved in the Wnt (zeige WNT2 Antikörper) pathway

3. Axin binds directly to the export factor CRM1 (zeige XPO1 Antikörper) in the presence of RanGTP

Human Axin 1 (AXIN1) Interaktionspartner

1. TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin (zeige CTNNB1 Antikörper) signaling pathway.

2. coexpression of APC5 (zeige ANAPC5 Antikörper) and Axin genes significantly downregulated Wnt (zeige WNT2 Antikörper) signaling in human SW480 CRC (zeige CALR Antikörper) cells and inhibited cell growth.

3. data delineate opposing roles for gamma-Pcdh isoforms in regulating Wnt (zeige WNT2 Antikörper) signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-Pcdh-C3 isoform

4. Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma (zeige MOK Antikörper) in a Chinese population.

5. Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (zeige PTPRK Antikörper)(e1)-RSPO3 (zeige RSPO3 Antikörper)(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (zeige WNT2 Antikörper) blockade by the porcupine (zeige PORCN Antikörper) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (zeige WNT2 Antikörper) pathway inhibitor AXIN1, with consequent protein loss.

6. role in the formation of degradasomes and degradation of beta-catenin (zeige CTNNB1 Antikörper) induced by the TNKSi G007-LK in colorectal cancer cells

7. VDR (zeige CYP27B1 Antikörper) is important for the maintenance of physiological level of Axin1

8. RUNX1 (zeige RUNX1 Antikörper) and AXIN1 proteins are strongly correlated in ER(-) tumors as well.

9. Mutagenesis and binding studies using the bivalent TNKS (zeige TNKS Antikörper) binding domain of Axin1 demonstrate that only certain ankyrin (zeige ANK Antikörper) repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS (zeige TNKS Antikörper) ankyrin (zeige ANK Antikörper) repeat conformations modulated by Axin1 interaction.

10. LGALS3 (zeige LGALS3 Antikörper) and AXIN1 genes affect tumor sizes and the mucinous component via Wnt (zeige WNT2 Antikörper)/ beta-catenin (zeige CTNNB1 Antikörper) pathway in the pathogenesis of colorectal cancer

Mouse (Murine) Axin 1 (AXIN1) Interaktionspartner

1. Axin-1 is critical for spindle organization and cell cycle progression during meiotic maturation in mouse oocytes.

2. VDR (zeige CYP27B1 Antikörper) is important for the maintenance of physiological level of Axin1

3. Axin1 promotes dendritic spine stabilization through Cdc42 (zeige CDC42 Antikörper)-dependent cytoskeletal reorganization.

4. Axin1 and Axin2 (zeige AXIN2 Antikörper) do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.

5. Study reports that NRF2 (zeige NFE2L2 Antikörper) participates in the formation of a protein complex with Axin1/GSK-3/beta-TrCP (zeige BTRC Antikörper) that is disrupted by WNT-3A (zeige WNT3A Antikörper), a prototypic canonical WNT (zeige WNT2 Antikörper) ligand, and leads to upregulation of the NRF2 (zeige NFE2L2 Antikörper) transcriptional signature.

6. Smurf1 (zeige SMURF1 Antikörper)-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 negatively regulates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.

7. This study demonistrated that Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex in mice.

8. results suggestg HSV-1 replication enhancement might be mediated by the axin RGS (zeige PITX2 Antikörper) domain.

9. an asymmetrical distribution pattern for Axin1 transcripts in 2-cell embryos.

10. Conditional disruption of Axin1 leads to development of liver tumors in mice.

Zebrafish Axin 1 (AXIN1) Interaktionspartner

1. beta-catenin1 cannot revert the ich (zeige ACE Antikörper) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (zeige PITX2 Antikörper) domain function.

2. analysis of differential role of Axin RGS (zeige PITX2 Antikörper) domain function in Wnt (zeige WNT2 Antikörper) signaling during anteroposterior patterning and maternal axis formation

3. Wnt (zeige WNT2 Antikörper)/Axin/beta-catenin (zeige CTNNB1 Antikörper) pathway has a role in ventral CNS development

4. Overactivation of Wnt (zeige WNT2 Antikörper)/Axin1/beta-catenin (zeige CTNNB1 Antikörper) signaling during late gastrulation leads to bilateral epithalamic expression of Nodal pathway genes independently of lateral plate mesoderm Nodal signaling.

5. A dorsalization pathway that is exerted by Axin/JNK (zeige MAPK8 Antikörper) signaling and its inhibitor Aida (zeige AIDA Antikörper) during vertebrate embryogenesis, is defined.

6. Dab2 (zeige DAB2 Antikörper) stabilizes Axin and attenuates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling by preventing PP1 from binding Axin