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Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
findings indicate a role of SPHK1 in modulating FB1 (zeige TFPT Proteine)-triggered cell death via SA and JA pathway interactions.
SPHK/phyto-S1P (zeige MBTPS1 Proteine) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (zeige MBTPS1 Proteine) system activates in parallel to viral replication and the inflammatory process induced by the virus.
Data indicate that the mitotic kinase Polo-like kinase 1 (PLK1) was an important effector of S1P-S1P5 signaling, and a new function of the SphK1-S1P pathway specifically in the control of mitosis in HeLa cells.
SphKs/Sphingosine-1-phosphate signaling is critical for the growth and survival of estrogen receptor (zeige ESR1 Proteine) positive MCF-7 human breast cancer cells.
SK1 activation is renoprotective via induction of autophagy in the fibrotic process
High SPHK1 expression is associated with ovarian Cancer.
Sphingosine kinase 1 is involved in papillary thyroid carcinoma development and progression and can serve as a potential biomarker predictive of lymph node metastasis.
High SPHK1 expression is associated with hepatocellular carcinoma.
we identified sphingosine kinase 1 (SPHK1) as a novel target of miR (zeige MLXIP Proteine)-506, the expression of which inhibited the SPHK1/Akt (zeige AKT1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway, which is activated in pancreatic cancer. High SPHK1 expression was significantly associated with poor survival in a large cohort of pancreatic cancer specimens.
Inhibition of SPHK1 in human acute myeloid leukemia (zeige BCL11A Proteine) cells induces MCL1 (zeige MCL1 Proteine) degradation and caspase (zeige CASP3 Proteine)-dependent cell death.
The analysis suggests that the catalytic function and regulation of SPHK1 and SPHK2 (zeige SPHK2 Proteine) might be dependent on their conformational mobility. (Review)
our data suggest that SphK1 modulates the expression of EMT (zeige ITK Proteine)-related markers and cell migration by regulating the expression of p-FAK (zeige PTK2 Proteine) in CRC (zeige CALR Proteine) cells. Thus, SphK1 may play a functional role in mediating the EMT (zeige ITK Proteine) process in CRC (zeige CALR Proteine).
These results suggest that SphK1 expression plays a pivotal role in the early stages of colon carcinogenesis
the recruitment of Sphk1 to sphingosine-enriched endocytic vesicles and the generation of sphingosine-1-phosphate facilitate membrane trafficking along the endosomal pathway.
donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.
Sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis by stimulation of proliferation of cancer cells.
These results highlight the importance of sphingosine and its conversion to sphingosine-1-phosphate by SphK1 in endocytic membrane trafficking.
Melatonin-treated cells also exhibited an inhibition of the SphK1/S1P (zeige S1PR1 Proteine) axis. Antifibrogenic effect of SphK1 inhibition was confirmed by treatment of LX2 cells with PF543. Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.
These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (zeige AGER Proteine)/SphK1 signaling pathway in db/db (zeige LEPR Proteine) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.
Keratinocyte-specific deletion of Traf2 (zeige TRAF2 Proteine), but not Sphk1 deficiency, disrupted TNF (zeige TNF Proteine) mediated NF-kappaB (zeige NFKB1 Proteine) and MAP kinase (zeige MAPK1 Proteine) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (zeige PKCd Proteine) activation plays an important role in promoting NF-kappaB (zeige NFKB1 Proteine) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (zeige PKCd Proteine) activation might be a potential therapeutic strategy for this disease.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1