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The pathogenicity of ZEB2 loss of heterozygosity in bovine is described.
High ZEB2 expression is associated with ewing sarcoma tumorigenesis and metastasis.
Study demonstrated that miR498 suppresses the growth and metastasis of liver cancer cells, partly at least, by directly targeting ZEB2, suggesting that miR498 may serve as a potential biomarker for the diagnosis and therapy of liver cancer.
miR-200c restored trastuzumab sensitivity and inhibited migration and invasion through suppressing ZEB1 and ZEB2. In summary, TGF-beta/ZEB2 axis plays an encouraging role in trastuzumab resistance of gastric cancer, while miR-200c overexpression downregulates ZEB1/ZEB2 and resensitizes drugs resistance.
miR-377 decreases proliferation and invasion of cervical cancer cells by directly targeting ZEB2.
Long non-coding RNA XIST (lncRNA XIST) and zinc finger E-box binding homeobox 2 (ZEB2) were targets of miR-367 and miR-141.
Results show that Linc-ROR competitively binds to miR-145, and subsequently up-regulates the expression of its target gene ZEB2 to promote the migration and invasion of hepatocellular carcinoma cells.
ZEB2 expression is resulting in drastic changes at the chromatin level with both clear DNA hypermethylation and histone modifications.ZEB2 directly binds to E-box sequences in the RAB25 promoter.
NORAD could serve as a ceRNA in cervical cancer progression by modulating miR-590-3p/SIP1 axis.
Study shows that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis.
Mutations in SIP1 gene are responsible for absence of its expression in Hirschsprung's disease.
Data identified SIP1 as a direct target of mir-145, and its expression was suppressed both at mRNA and protein levels in colorectal neoplasm mediating cancer cell proliferation, migration and invasion.
miR-146a promoted hepatitis b virus replication by targeting ZEB2.
ZEB2 attenuated LPS-induced inflammation cytokine secretion possibly through suppressing the NF-kappaB signaling pathway
The percentages of ZEB1 high expression and ZEB2 high expression were 31.9% (29/91) and 41.9% (36/91), respectively. High expression of ZEB2 was significantly associated with lower survival rate of GBM patients (P=0.001).
Results suggest that Src promotes EGF-stimulated EMT and migration by upregulation of ZEB1 and ZEB2 through AKT signaling pathway in gastric cancer cells.
miR-192 was a critical factor of HS formation and facilitated skin fibrosis by targeting directly SIP1.
Results show that ZEB2 is highly expressed in small cell lung cancer (SCLC) tissue samples and consistent with E2F1 expression. Also, further data showed that E2F1 regulated ZEB2 expression through E2F1 binding sites on the promoter of ZEB2 in SCLC.
Our study confirms that the two susceptibility loci ZFHX1B and SNTB1 are associated with moderate to high myopia in a Han Chinese population, as well as in a European population, when both SNPs are combined.
High expression of ZEB2 is associated with drug resistance in gastric cancer.
The present study validated the prognostic value and clinicopathological association of ZEB1 and ZEB2 in digestive cancers, especially in gastric cancer.
Data show that dopaminergic hyperinnervation of the striatum, without an increase in the numbers of midbrain dopaminergic neurons, in conditional zinc finger E-box binding homeobox 2 protein (Zeb2) knockout mice.
ZEB2 is critical for maintaining the tissue identities of macrophages. Loss of ZEB2 results in tissue-specific changes in different macrophage populations and their subsequent disappearance. In Kupffer cells, ZEB2 maintains LXRa expression, loss of which reproduces the change in Kupffer cell identity and their disappearance.
In the development of LPS-induced early pulmonary fibrosis, miR-200b/c was downregulated, whereas ZEB1/2 was upregulated; miR-200b/c exerts a protective effect by targeting ZEB1/2.
The miR-200 family is specifically induced during late neuronal differentiation stages. Using in vivo strategies we interfered with the entire miR-200 family in loss- and gain-of-function settings, showing a role of miR-200 in neuronal maturation. This function is mediated by targeting the transcription factor Zeb2.
Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate
We demonstrate that neocortical neurons that have only one copy of Sip1 (heterozygous, Sip1(fI/wt)), are more sensitive to both NMDA- and AMPA- receptors agonists as compared to wild type neurons (Sip1(wt/wt)).
miR-30a-5p directly targeted the 3'-UTR of ZEB2 and suppressed clear cell renal cell epithelial-mesenchymal transition.
Zeb2 is critical in embryonic stem cells for exit from the epiblast state.
regulates the morphogenesis of mesenchyme-derived nephrons and is required for proximal tubule development and glomerulotubular junction formation
characterization of differentiation dynamics reveals that Sip1 has a role in promoting the timely differentiation of retinal interneurons, assuring generation of the proper number of the diverse neuronal and glial cell subtypes that constitute the functional retina in mammals.
Collectively, the results demonstrate that Zeb2 controls adult hematopoietic differentiation and lineage fidelity through widespread modulation of dominant signaling pathways that may contribute to blood disorders.
Zeb2 controls Schwann cell maturation by recruiting HDAC1/2-NuRD complexes and inhibiting a Notch-Hey2 signaling axis
that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life
ZEB2 transcriptionally represses genes that regulate myeloid differentiation, including genes involved in cell adhesion and migration; epigenetic silencing of the miR-200 family microRNAs affects ZEB2 expression.
Zeb2 regulates commitment to both the cDC2 and pDC lineages through repression of Id2.
Control of differentiation of mouse enteric nervous system progenitor cells by EDN3 requires regulation of Ednrb expression by SOX10 and ZEB2.
TFAP2A is a conserved component of the core network that regulates EMT, acting as a repressor of many genes, including ZEB2.
SIP1 plays an essential role in lipid metabolism during the liver regeneration process and might be a regulator of liver regeneration following liver injury.
The Ppa could also target the third core EMT regulatory factor Sip1 for proteasomal degradation.
Data show that zebrafish sip1a and sip1b are essential for normal axial and neural patterning.
Knockdown of ChCh or Sip1a results in misshapen somites that are short and narrow.
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
zinc finger homeobox 1b
, zinc finger E-box-binding homeobox 2
, SMAD interacting protein 1
, Smad-interacting protein 1
, smad-interacting protein 1
, zinc finger homeobox protein 1b
, smad interaction protein 1
, zinc finger E-box binding homeobox 2
, zinc finger homeobox protein
, Smad-interacting protein-1a
, transcription factor SIP1a
, Smad-interacting protein-1b
, transcription factor SIP1b