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The pathogenicity of ZEB2 loss of heterozygosity in bovine is described.
NORAD could serve as a ceRNA in cervical cancer progression by modulating miR-590-3p/SIP1 axis.
Study shows that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis.
Mutations in SIP1 gene are responsible for absence of its expression in Hirschsprung's disease.
Data identified SIP1 as a direct target of mir-145, and its expression was suppressed both at mRNA and protein levels in colorectal neoplasm mediating cancer cell proliferation, migration and invasion.
miR-146a promoted hepatitis b virus replication by targeting ZEB2.
ZEB2 attenuated LPS-induced inflammation cytokine secretion possibly through suppressing the NF-kappaB signaling pathway
The percentages of ZEB1 high expression and ZEB2 high expression were 31.9% (29/91) and 41.9% (36/91), respectively. High expression of ZEB2 was significantly associated with lower survival rate of GBM patients (P=0.001).
Results suggest that Src promotes EGF-stimulated EMT and migration by upregulation of ZEB1 and ZEB2 through AKT signaling pathway in gastric cancer cells.
miR-192 was a critical factor of HS formation and facilitated skin fibrosis by targeting directly SIP1.
Results show that ZEB2 is highly expressed in small cell lung cancer (SCLC) tissue samples and consistent with E2F1 expression. Also, further data showed that E2F1 regulated ZEB2 expression through E2F1 binding sites on the promoter of ZEB2 in SCLC.
Our study confirms that the two susceptibility loci ZFHX1B and SNTB1 are associated with moderate to high myopia in a Han Chinese population, as well as in a European population, when both SNPs are combined.
High expression of ZEB2 is associated with drug resistance in gastric cancer.
The present study validated the prognostic value and clinicopathological association of ZEB1 and ZEB2 in digestive cancers, especially in gastric cancer.
ZEB2 suppress apoptosis of vascular endothelial cells induced by high glucose through MAPK pathway activation, which provides a novel insight and therapeutic target for endothelial injury.
Study found SIP1 expression was up-regulated and closely related to diminished survival in intrahepatic cholangiocarcinoma (ICC) patients. It is the direct and functional target of miR-590-3p in ICC cells.
miR-30a-5p directly targeted the 3'-UTR of ZEB2 and suppressed clear cell renal cell epithelial-mesenchymal transition.
Our data demonstrate a directly negative feedback loop between miR-203 and ZEB2 participating in tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma
ZEB2 expression was higher in HCC tissues and was negatively related to miR-211-5p levels.
Study shows that ZEB2 expression is controlled at protein synthesis level in cancer cells. Authors propose that the underlying mechanism represents a novel regulatory scheme based on ribosome pausing and degradation of the nascent peptide.
Simultaneous knockdown of both ZEB1 and ZEB2 expression establishes ZEB1 as a transcriptional repressor of E-cadherin and a driver of docetaxel resistance in docetaxel-resistant prostate cancer cells.
The Ppa could also target the third core EMT regulatory factor Sip1 for proteasomal degradation.
Data show that zebrafish sip1a and sip1b are essential for normal axial and neural patterning.
Knockdown of ChCh or Sip1a results in misshapen somites that are short and narrow.
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
zinc finger homeobox 1b
, zinc finger E-box-binding homeobox 2
, SMAD interacting protein 1
, Smad-interacting protein 1
, smad-interacting protein 1
, zinc finger homeobox protein 1b
, smad interaction protein 1
, zinc finger E-box binding homeobox 2
, zinc finger homeobox protein
, Smad-interacting protein-1a
, transcription factor SIP1a
, Smad-interacting protein-1b
, transcription factor SIP1b