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The pathogenicity of ZEB2 loss of heterozygosity in bovine is described.
The percentages of ZEB1 high expression and ZEB2 high expression were 31.9% (29/91) and 41.9% (36/91), respectively. High expression of ZEB2 was significantly associated with lower survival rate of GBM patients (P=0.001).
Results suggest that Src (zeige SRC Proteine) promotes EGF (zeige EGF Proteine)-stimulated EMT (zeige ITK Proteine) and migration by upregulation of ZEB1 and ZEB2 through AKT (zeige AKT1 Proteine) signaling pathway in gastric cancer cells.
miR (zeige MLXIP Proteine)-192 was a critical factor of HS formation and facilitated skin fibrosis by targeting directly SIP1 (zeige GEMIN2 Proteine).
Results show that ZEB2 is highly expressed in small cell lung cancer (SCLC) tissue samples and consistent with E2F1 (zeige E2F1 Proteine) expression. Also, further data showed that E2F1 (zeige E2F1 Proteine) regulated ZEB2 expression through E2F1 (zeige E2F1 Proteine) binding sites on the promoter of ZEB2 in SCLC.
Our study confirms that the two susceptibility loci ZFHX1B and SNTB1 are associated with moderate to high myopia in a Han Chinese population, as well as in a European population, when both SNPs are combined.
High expression of ZEB2 is associated with drug resistance in gastric cancer.
The present study validated the prognostic value and clinicopathological association of ZEB1 and ZEB2 in digestive cancers, especially in gastric cancer.
ZEB2 suppress apoptosis of vascular endothelial cells induced by high glucose through MAPK (zeige MAPK1 Proteine) pathway activation, which provides a novel insight and therapeutic target for endothelial injury.
Study found SIP1 (zeige GEMIN2 Proteine) expression was up-regulated and closely related to diminished survival in intrahepatic cholangiocarcinoma (ICC) patients. It is the direct and functional target of miR (zeige MLXIP Proteine)-590-3p in ICC cells.
miR (zeige MLXIP Proteine)-30a-5p directly targeted the 3'-UTR of ZEB2 and suppressed clear cell renal cell epithelial-mesenchymal transition.
miR (zeige MLXIP Proteine)-192 was a critical factor of HS formation and facilitated skin fibrosis by targeting directly SIP1.
The miR (zeige MLXIP Proteine)-200 family is specifically induced during late neuronal differentiation stages. Using in vivo strategies we interfered with the entire miR (zeige MLXIP Proteine)-200 family in loss- and gain-of-function settings, showing a role of miR (zeige MLXIP Proteine)-200 in neuronal maturation. This function is mediated by targeting the transcription factor Zeb2.
Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate
We demonstrate that neocortical neurons that have only one copy of Sip1 (heterozygous, Sip1(fI/wt)), are more sensitive to both NMDA- and AMPA (zeige GRIA3 Proteine)- receptors agonists as compared to wild type neurons (Sip1(wt/wt)).
Zeb2 is critical in embryonic stem cells for exit from the epiblast state.
characterization of differentiation dynamics reveals that Sip1 has a role in promoting the timely differentiation of retinal interneurons, assuring generation of the proper number of the diverse neuronal and glial cell subtypes that constitute the functional retina in mammals.
Collectively, the results demonstrate that Zeb2 controls adult hematopoietic differentiation and lineage fidelity through widespread modulation of dominant signaling pathways that may contribute to blood disorders.
Zeb2 controls Schwann cell maturation by recruiting HDAC1 (zeige HDAC1 Proteine)/2-NuRD complexes and inhibiting a Notch (zeige NOTCH1 Proteine)-Hey2 (zeige HEY2 Proteine) signaling axis
that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life
The Ppa (zeige FBXL14 Proteine) could also target the third core EMT (zeige ITK Proteine) regulatory factor Sip1 (zeige GEMIN2 Proteine) for proteasomal degradation.
Data show that zebrafish sip1a and sip1b are essential for normal axial and neural patterning.
Knockdown of ChCh (zeige CHURC1 Proteine) or Sip1a results in misshapen somites that are short and narrow.
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
zinc finger homeobox 1b
, zinc finger E-box-binding homeobox 2
, SMAD interacting protein 1
, Smad-interacting protein 1
, smad-interacting protein 1
, zinc finger homeobox protein 1b
, smad interaction protein 1
, zinc finger E-box binding homeobox 2
, zinc finger homeobox protein
, Smad-interacting protein-1a
, transcription factor SIP1a
, Smad-interacting protein-1b
, transcription factor SIP1b