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Study provides evidence that the renal specific phenotype of nail (zeige CD244 Proteine) patella-like renal disease associated with LMX1B (zeige LMX1B Proteine) R246Q mutation may be due to dominant negative effect on WT1(- KTS) specific isoforms causing a disruption of the WT1 isoform ratio and subsequent decrease in key podocyte related genes.
MDS (zeige PAFAH1B1 Proteine) and acute myeloid leukemia (zeige BCL11A Proteine) were the major target diseases to provide proof of concept for the therapeutic potential of the WT1 peptide vaccine. WT1 vaccination-induced clinical responses or usefulness were also shown for chronic myeloid leukemia (zeige BCL11A Proteine), multiple myeloma, and acute lymphoblastic leukemia, as well as various types of solid cancers. Non-Hodgkin's lymphoma and myeloproliferative neoplasms may be target diseases
Total heterogeneous methylation of WT1 conferred a significantly higher risk of Colorectal Cancer.The gene methylation status of blood leukocytes may be associated with CRC (zeige CALR Proteine) risk.
excessive expression of WT1 was detected in ovaries of Polycystic Ovary Syndrome patients providing novel insights into the relationship between hyperandrogenism and polycystic ovaries of PCOS and WT1.
WT1 isoforms containing or lacking an insert, KTS, between zinc finger 3 (zeige YIPF3 Proteine) and 4 have different binding patterns to both DNA and RNA targets in acute myeloid leukemia (zeige BCL11A Proteine). (Review)
study identifies a novel mechanism of hepatocellular carcinoma inhibition through beta-catenin (zeige CTNNB1 Proteine)-independent Wnt (zeige WNT2 Proteine) signalling, which is regulated by WT1-associated LEF1 (zeige LEF1 Proteine) repression. The study also highlights mangiferin as a promising Wnt (zeige WNT2 Proteine) inhibitor for HCC (zeige FAM126A Proteine) treatment.
our data demonstrate that WT1 protein undergoes proteolytic processing by caspase-3 (zeige CASP3 Proteine) in chemotherapeutic drugs-induced apoptosis. This processing is associated with a reduction of WT1 protein.
WT1 reduces malignancy of malignant mesothelioma cell lines and might be a new molecular target in mesothelioma therapy
WT1 overexpression indicates a poor prognosis in patients with some gynecological tumors, but more studies are needed to confirm these findings.
No increased frequencies were observed for WT1-specific T cells.
WT1 interference with Wnt (zeige WNT2 Proteine) signaling represents an important mode of its action relevant to the suppression of tumor growth and guidance of development.
Sodium butyrate-induced hyperacetylation up-regulates WT1 expression in porcine kidney fibroblasts, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells.
Results indicate that WT1 plays important roles in the development of porcine preimplantation embryos, but not in oocyte maturation.
WT1 is expressed in porcine fetal fibroblasts, but the levels of expression were much lower compared to porcine primary kidney fibroblasts and swine testis, and WT1 is essential for the maintenance of development and survival of porcine fetal fibroblasts
Study summarizes the different roles of WT1b gene in the embryonic zebrafish kidney and the adult kidney as well. [review]
While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
WT1 expression in CoRL is important for the glomerular response to damage. When WT1 is selectively deleted in CoRL in the setting of podocyte loss, their proliferation and migration to the glomerulus, and to some extent their transdifferentiation toward a podocyte fate through MET changes, are markedly reduced.
this study shows that WT1 ameliorates podocyte injury via repression of EZH2 (zeige EZH2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway in diabetic nephropathy
both the local oxygen environment and WT1, which enhances KDR (zeige KDR Proteine) expression, contribute to sex-specific Sox9 (zeige SOX9 Proteine) expression in developing murine gonads
The authors show that the posthepatic mesenchymal plate coelomic epithelium gives rise to a mesenchyme that populates the pleuroperitoneal folds isolating the pleural cavities before the migration of the somitic myoblasts. This process fails when Wt1 is deleted from this area.
Study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction. Data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
WT1 is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (zeige SF1 Proteine) expression. Without Wt1, the expression of Sf1 (zeige SF1 Proteine) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
study provides novel insights into the role of WT1 and GATA4 (zeige GATA4 Proteine) during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
WT1 regulates reporter gene expression through interaction with 3' UTR-binding sites
These results indicate that Osr1 (zeige OSR1 Proteine) and Wt1 act synergistically to regulate nephron endowment by controlling metanephric mesenchyme specification during early nephrogenesis.
Wt1 regulates the development of FLC.
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Wilms tumor protein
, amino-terminal domain of EWS
, last three zinc fingers of the DNA-binding domain of WT1
, Chick Wilm's tumour protein
, Wilms tumor 1
, Wilms tumor protein homolog A
, Wilms tumor protein homolog
, Wilms tumor suppressor protein 1b
, Wilm's tumor suppressor
, Wilms tumor protein homolog B