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hWW45 (zeige SAV1 Proteine) is required to enhance MST1 (zeige MST1 Proteine)-mediated apoptosis in vivo and thus is a critical player in an MST1 (zeige MST1 Proteine)-driven cell death signaling pathway.
MST1 (zeige MST1 Proteine)-FOXO1 (zeige FOXO1 Proteine) signaling is an important link survival factor deprivation-induced neuronal cell death
hSav1 is a newly identified protein that interacts with Mst1 (zeige MST1 Proteine) and augments Mst1 (zeige MST1 Proteine)-mediated apoptosis.
tolerance to increased levels of intracellular ROS (zeige ROS1 Proteine) provided by the Mst1 (zeige MST1 Proteine)-FoxOs signaling pathway is crucial for the maintenance of naive T cell homeostasis in the periphery
The identified Mst1 (zeige MST1 Proteine) as a binding partner that interacts with PHLPPs both in vivo and in vitro. PHLPPs dephosphorylate Mst1 (zeige MST1 Proteine) on the T387 inhibitory site, which activate Mst1 (zeige MST1 Proteine) and its downstream effectors p38 (zeige CRK Proteine) and JNK (zeige MAPK8 Proteine) to induce apoptosis.
H2AX (zeige H2AFX Proteine) is a substrate of MST1 (zeige MST1 Proteine), which functions to induce apoptotic chromatin condensation and DNA fragmentation
novel regulatory mechanism involving the phosphorylation of Sirt1 (zeige SIRT1 Proteine) by MST1 (zeige MST1 Proteine) kinase which leads to p53 (zeige TP53 Proteine) activation, with implications for our understanding of signaling mechanisms during DNA damage-induced apoptosis
Mst1 (zeige MST1 Proteine) exhibits a growth promoting activity (zeige CNTF Proteine) in HCC (zeige FAM126A Proteine) cells upon NORE1B (zeige RASSF5 Proteine) downregulation.
Mst1 (zeige MST1 Proteine) inactivates Prdx1 (zeige PRDX1 Proteine) by phosphorylating it at Thr (zeige TRH Proteine)-90 and Thr (zeige TRH Proteine)-183, leading to accumulation of hydrogen peroxide in cells.
results suggest that Mst1 (zeige MST1 Proteine) coordinately regulates autophagy and apoptosis by phosphorylating Beclin1 (zeige BECN1 Proteine) and consequently modulating a three-way interaction among Bcl-2 (zeige BCL2 Proteine) proteins, Beclin1 (zeige BECN1 Proteine) and Bax (zeige BAX Proteine)
NDR1 (zeige STK38 Proteine) kinase, activated by the Rap1 (zeige TERF2IP Proteine) signaling cascade through RAPL (zeige RASSF5 Proteine) and Mst1 (zeige MST1 Proteine)/Mst2 (zeige STK3 Proteine), associated with and recruited kindlin-3 (zeige FERMT3 Proteine) to the immunological synapses, which was required for high-affinity LFA-1 (zeige ITGAL Proteine)/ICAM-1 (zeige ICAM1 Proteine) binding.[Kindlin-3 (zeige FERMT3 Proteine)]
the present study demonstrated that deletion of Mst1 (zeige MST1 Proteine) attenuated neuronal loss and improved locomotor function in a mouse model of spinal cord injury, via preserving mitochondrial function, attenuating mitochondria-mediated apoptotic pathway, and suppressing inflammation, at least in part.
Mst1 (zeige MST1 Proteine) deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.
mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration in a mouse model of myocardial infarction.
Studies indicate that Hippo (Hpo (zeige GFER Proteine); MST1 (zeige MST1 Proteine)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (zeige MST1 Proteine) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (zeige MST1 Proteine) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (zeige MST1 Proteine)-Mst2 (zeige STK3 Proteine)-Rac (zeige AKT1 Proteine) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (zeige MAP1LC3A Proteine) by the STK3 (zeige PKN1 Proteine) and STK4 is essential for autophagy.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1