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this study showed that Rab23 regulates Nodal signaling in left- right patterning of th emouse and zebrafish.
Our findings have uncovered a hitherto unknown effector of Rab23 and demonstrate how Rab23 could mediate the transport of Kif17 (zeige KIF17 Proteine) to the primary cilium
D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17 (zeige KIF17 Proteine). This targeting mechanism critically depends on Rab23.
Rab23 regulates subcellular localization of essential components of the Hedgehog (zeige SHH Proteine) pathway that act downstream of Smoothened and upstream of Gli (zeige GLI1 Proteine) proteins.
Expression of Rab23 in the adult brain is suggestive, however, of having a postnatal function beyond its role in embryonic development.
Rab23 functions downstream of Smo and affects the function of the Shh (zeige SHH Proteine)-regulated Gli (zeige GLI1 Proteine) family of transcription factors
Rab23 is involved in the control of Sox9 (zeige SOX9 Proteine) expression via Gli1 (zeige GLI1 Proteine) protein
miR (zeige MLXIP Proteine)-429 was down-regulated in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) tissues and cells. Up regulation of miR (zeige MLXIP Proteine)-429 decreased the migratory capacity and reversed the EMT (zeige ITK Proteine) to MET in HCC (zeige FAM126A Proteine) cells. RAB23 was confirmed as a target of miR (zeige MLXIP Proteine)-429.
Down-regulation of Rab23 suppressed the proliferation, migration and invasion of prostate cancer cells.
Rab23 serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through Rac1 activity
High Rab23 expression is associated with bladder cancer.
Forced expression of MiR (zeige MLXIP Proteine)-92b decreased the mRNA and protein level of RAB23, and RAB23 rescued the biological functions of miR (zeige MLXIP Proteine)-92b. Taken together, this study revealed the oncogenic roles and the regulation of RAB23 in esophageal squamous cell carcinoma, suggesting RAB23 might be a therapeutic target
Rab23 enhance squamous cell carcinoma cell invasion via up-regulating Rac1.
Rab23 is expressed in breast cancer cells, and ectopic expression of Rab23 inhibits the growth and proliferation as well as induces cell apoptosis in breast cancer cells These effects may be due to the inhibition by Rab23 of Gli1 and Gli2 mRNA expression
Data indicate the essential role of GTP binding protein RAB 23 (Rab23) in pancreatic ductal adenocarcinoma (PDAC) inva-sion, motility and metastasis.
Rab23 was a target gene of miR (zeige MLXIP Proteine)-367, and ectopic expression of Rab23 could reverse the invasion and migration inhibitory activity of miR (zeige MLXIP Proteine)-367.
The inhibition of the Rab23 cycle decreases the expression and nuclear localization of Gli1 (zeige GLI1 Proteine).
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
RAB23, member RAS oncogene family
, Ras-related protein Rab-23
, ras-related protein Rab-23
, open brain 2
, protein open brain
, RAB family small GTP binding protein RAB 23