Plexin B2 Proteine (PLXNB2)

Human Plexin B2 (PLXNB2) Interaktionspartner

1. Study shows that plexin-B2 (PLXNB2) is the functional receptor for ANG (zeige ANG Proteine) in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.

2. Analysis of the interaction of Plexin-B1 (zeige PLXNB1 Proteine) and Plexin-B2 with Rnd family proteins shows lack of binding specificity.

3. plexin-B2 is a downstream target for Rnd3 (zeige RND3 Proteine), which contributes to its cellular function.

4. Results show that decreased expression of Sema4D (zeige SEMA4D Proteine), plexin-B1 (zeige PLXNB1 Proteine) and -B2 was associated with local recurrence and poor prognosis of breast neoplasm.

5. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (zeige ARHGEF11 Proteine) and leukemia-associated RhoGEF (LARG (zeige ARHGEF12 Proteine)), use their PDZ domains to bind class B plexins and play critical roles in signaling.

6. Plexin-B2 promotes glioma invasion and vascularization

7. Blocking of CD100 (zeige SEMA4D Proteine), plexin B1 (zeige PLXNB1 Proteine) and/or B2 in adhesion experiments have shown that both CD100 (zeige SEMA4D Proteine) and plexins act as adhesion molecules involved in monocyte-endothelial cell binding.

8. In endometrial luminal epithelium, cadherin 6 (zeige CDH6 Proteine), desmoglein 2 (zeige DSG2 Proteine) and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.

9. High PLEXIN B2 expression is associated with high-grade gliomas.

10. Plexin B2 associates directly with two members of a recently identified family of Dbl (zeige MCF2 Proteine) homology/pleckstrin (zeige PLEK Proteine) homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF (zeige ARHGEF11 Proteine), and Leukemia-associated Rho GEF (zeige SLC2A4RG Proteine) (LARG (zeige ARHGEF12 Proteine)).

Mouse (Murine) Plexin B2 (PLXNB2) Interaktionspartner

1. Germinal center recruitment of follicular T helper cells requires Plexin B2.

2. Plexin-B1 (zeige PLXNB1 Proteine) and -B2 play redundant or compensatory roles during forebrain development to ensure proper neuronal production and neocortical expansion.

3. During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle

4. Data show that the Plexin B2 receptor interacts physically and functionally with Rnd3 (zeige RND3 Proteine) and stimulates RhoA (zeige RHOA Proteine) activity in migrating cortical neurons.

5. In contrast to the GAP domain mutants, Plexin-B2 transgenic mice defective in Rho guanine nucleotide exchange factor binding are viable and fertile but exhibit abnormal development of the liver vasculature

6. these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of subventricular zone-derived neuroblasts

7. Data an association between Plexin-B2 and Plexin-D1 (zeige PLXND1 Proteine) with the negative regulation of IL-12 (zeige IL12A Proteine)/IL-23p40 in DCs.

8. In vitro blocking of plexin B2 or CD100 (zeige SEMA4D Proteine) inhibited gamma-delta T cell activation.

9. Data show that Plexin-B2 functions in macrophages as a negative regulator of the GTPases Rac (zeige AKT1 Proteine) and Cdc42 (zeige CDC42 Proteine) and as a negative regulator of basal cell motility and wound healing.

10. deletion of Plexin B2 (Plxnb2), a semaphorin receptor that is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney, results in renal hypoplasia and occasional double ureters