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A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 (zeige IRX3 Proteine) gene were verified in 215 nonsyndromic congenital heart disease patients.
this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 (zeige IRX3 Proteine) locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 (zeige IRX3 Proteine) and HLA-DRB1 (zeige HLA-DRB1 Proteine) are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis.
In osteosarcoma cells and lines, IRX1 (zeige IRX3 Proteine) overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice.
Findings suggest that methylation-associated down-regulation of EBF3 (zeige MAPRE3 Proteine) and IRX1 (zeige IRX3 Proteine) genes may play an important role in a pathogenic effect of TGF-beta (zeige TGFB1 Proteine) on RASFs.
Helicobacter pylori infection contributes to IRX1 (zeige IRX3 Proteine) promoter methylation in gastric mucosa.
enforcing IRX1 (zeige IRX3 Proteine) expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion.
Homeobox (zeige Lbx1 Proteine) gene IRX1 (zeige IRX3 Proteine) is a tumor suppressor gene in gastric carcinoma.
Results verify IRX1 (zeige IRX3 Proteine), EBF3 (zeige MAPRE3 Proteine), SLC5A8, SEPT9 (zeige SEPT9 Proteine), and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1 (zeige IRX3 Proteine), EBF3 (zeige MAPRE3 Proteine), SLC5A8, and SEPT9 (zeige SEPT9 Proteine).
Frequent methylation of IRX1 (zeige IRX3 Proteine) gene is associated with head and neck squamous cell carcinoma
Irx1 regulates Foxj1 (zeige FOXJ1 Proteine) and Sox9 (zeige SOX9 Proteine) to control cell differentiation during development.
This homeobox protein (zeige HOXA1 Proteine) is expressed during early lung development.
This homeobox protein (zeige HOXA1 Proteine) is expressed during digit development and is an early marker for this development.
Observations suggest that Irx2 (zeige IRX2 Proteine) functions downstream of irx1a to control shh (zeige SHH Proteine) expression in the retina. Study proposed a novel transcriptional cascade of ath5 (zeige ATOH7 Proteine)-irx1a-irx2a in the regulation of hedgehog (zeige SHH Proteine) waves during vertebrate retinal development.
Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
Our results reveal a role for Iroquois genes in controlling hedgehog (zeige SHH Proteine) expression during vertebrate retinogenesis.
irx1a is not required for the initial specification but it is required for the complete differentiation of 5HT (zeige DDC Proteine) neurons
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13.
homeodomain protein IRXA1
, iroquois homeobox protein 1
, iroquois-class homeodomain protein IRX-1
, iroquois homologue-1
, iroquois homeobox 1
, iroquois-class homeodomain protein irx-1
, Iroquois related homeobox 1
, Iroquois homeobox protein 1-A
, homeobox Iro protein
, iroquois-class homeodomain protein irx-1-A
, LOW QUALITY PROTEIN: iroquois-class homeodomain protein IRX-1
, Iroquois homeobox protein 1-B
, iroquois-class homeodomain protein irx-1-B