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Simulation of HEY1 Ser (zeige SIGLEC1 Proteine)-68 phosphorylation prevents its interaction with p53 (zeige TP53 Proteine), RPL11 (zeige RPL11 Proteine) and MDM2 (zeige MDM2 Proteine) and abolishes HEY1 migration to nucleolar caps (zeige CAPS Proteine) upon ribosomal stress. Our findings uncover a novel mechanism for cross-talk between Notch (zeige NOTCH1 Proteine) signalling and nucleolar stress
Pancreatic involvement occurs in mesenchymal chondrosarcoma harboring the HEY1-NCOA2 (zeige NCOA2 Proteine) gene fusion.
HGF (zeige HGF Proteine)-induced FRA1 (zeige FOSL1 Proteine) activation is associated with the fibrosis-dependent development of Hepatocellular Carcinoma.
Expression of Hey1 induces translocation of FBXO45 (zeige FBXO45 Proteine) into the nucleus.
Overexpression of HEY1 and HEY2 (zeige HEY2 Proteine) in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.
bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 and Hey2 (zeige HEY2 Proteine) gene expression within the first few hours after medium change
PML (zeige PML Proteine) degradation mechanism through Notch (zeige NOTCH1 Proteine)/Hey1-induced repression of the PML (zeige PML Proteine) deubiquitinase USP11 (zeige USP11 Proteine) involved in brain tumour pathogenesis
MMP9 (zeige MMP9 Proteine) was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells. Knockdown of HEY1 decreased the expression of MMP9 (zeige MMP9 Proteine).
In prostate tumors, the overexpression of PTOV1 (zeige PTOV1 Proteine) was associated with decreased expression of HEY1 and HES1 (zeige HES1 Proteine), and this correlation was significant in metastatic lesions.
a new HRD1 (zeige SYVN1 Proteine)-associated membrane protein named HERP2, which is homologous to the previously identified HRD1 (zeige SYVN1 Proteine) partner HERP1 (zeige HEY2 Proteine). Despite sequence homology, HERP2 is constitutively expressed in cells, whereas HERP1 (zeige HEY2 Proteine) is highly induced by ER stress.
Data implied that Hey2 (zeige HEY2 Proteine) function is restricted to transient amplifying cells of the ameloblast cell lineage and that Hey1 plays a role in the composition of the subodontoblastic layer, in addition to ameloblast differentiation.
stable Hey1overexpressing cells expressed higher levels of dentin sialophosphoprotein (DSPP (zeige DSPP Proteine)) and exhibited higher mineralization capabilities following stimulation by differentiation medium. Furthermore, RNA interferencemediated knockdown of Hey1 downregulated the expression levels of DSPP (zeige DSPP Proteine) in OLCs stimulated by differentiation medium.
A Jagged1 (zeige JAG1 Proteine)-Hey1 signal might mediate the impairment of angiogenesis induced by Ang II (zeige AGT Proteine) during cardiac hypertrophy.
Cyclic stretch enhanced the BMP-2induced osteoblastic differentiation through the inhibition of Hey1.
Hes (zeige ATCAY Proteine)/Hey signaling at the Atoh1 (zeige ATOH1 Proteine) promoter has a role in selection of cell fate in the organ of Corti
These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII (zeige NR2F2 Proteine) via downregulating the Notch (zeige NOTCH1 Proteine) signaling target gene Hey1.
Hey proteins mechanistically repress target genes via histone deacetylase (zeige HDAC1 Proteine) recruitment and histone deacetylation.
Hey1 and Hey2 (zeige HEY2 Proteine) in endothelial cells play important roles in vascular development.
findings indicate that Hey1 and Hey2 (zeige HEY2 Proteine) control the spatial and temporal pattern of auditory HC differentiation.
This study demonistrated that demonstrates that the lack of Hesr1 leads to an alteration in sensitivity to dopamine accompanied by enhanced prepulse inhibition.
abrogation of Hey1 function in adult pallial Neural stem cells in vivo, including quiescent Neural stem cells, leads to their differentiation without affecting their proliferation state.
Expression of seven hairy/E(spl (zeige SGPL1 Proteine)) (her) genes is reported in three neurogenic areas of the adult zebrafish brain (telencephalon, hypothalamus, and midbrain) in relation to radial glia, proliferation, and neurogenesis.
hey1 represents a target of Delta-Notch (zeige NOTCH1 Proteine) signaling dynamically expressed during somite formation in zebrafish
Results suggest that the negative regulatory loops between BMP/Tbx2 (zeige TBX2 Proteine) and Gremlin (zeige GREM1 Proteine) or Hey1 are responsible for defining the territory of the pronephric nephron.
HRT1 encodes a bhlh domain motif, a transcription repressor, which acts as an extended dimerization domain that contributes to the selection of partners.
XHRT1 plays an important role in glomerular development and early proximodistal patterning. [Xenopus HRT1]
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
HES-related repressor protein 1
, HES-related repressor protein 2
, basic helix-loop-helix protein OAF1
, cardiovascular helix-loop-helix factor 2
, class B basic helix-loop-helix protein 31
, hairy and enhancer of split-related protein 1
, hairy-related transcription factor 1
, hairy/enhancer-of-split related with YRPW motif protein 1
, bHLH protein Hesr-1/Hey1
, cardiovascular basic helix-loop-helix factor 2
, Hairy/E(spl)-related with YRPW motif 1
, basic helix-loop-helix transcription factor
, protein xbc8