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BMP-12 activates tenogenic pathway in human adipose stem cells.
The Barrett-associated variants at GDF7 and TBX5 (zeige TBX5 Antikörper) also increase esophageal adenocarcinoma risk.
closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (zeige TBX5 Antikörper) (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development
BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1 (zeige GARS Antikörper)/5/8 pathway.
studies show that even though tenogenic (BMP 12 and BMP 13 (zeige GDF6 Antikörper)) and osteogenic (BMP2 (zeige BMP2 Antikörper)) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
In mouse, the expression of Gdf7 in roof plate cells is required for the fidelity of commissural axon growth.
Choroid plexus relationships using normal and Gdf7 (Bmp12) transgenic embryos to fate map or ablate dorsal midline cells.
compensation by Gdf-5 (zeige GDF5 Antikörper) may be at least in part responsible for the absence of a strong phenotype in GDF-7 deficient mice
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord.
growth/differentiation factor 16 precursor protein
, growth/differentiation factor 7