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we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development.
Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard may play a role in the fine-tuning of WNT signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp/+) embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a-Ror-Dishevelled signaling constitutes a core noncanonical Wnt pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 coordinates myogenesis through the regulation of Dvl2 mRNA.
GABARAPL1 negatively regulates Wnt/beta-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Dishevelled 2 co-precipitated with ephrin B2 and vice versa, suggesting an endogenous interaction between Dvl2 and ephrin B2
In Nodal null embryos, membrane localisation of Dvl2 is reduced, while in mutants for the Nodal inhibitor Lefty1, Dvl2 is ectopically membrane localised, establishing a role for Nodal in modulating planar cell polarity signalling.
Data shsow that mutation of residues at the DEP-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 for mu2.
Small intestines of Dvl2 mutants are shortened, reflecting in part a reduction of their crypt diameter and cell size. Results implicate Dvl2 and mTOR in the progression of colorectal neoplasia
Ror2/Fz7 receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl.
Wnt3a stimulates Src docking to Dvl2 and activation of Src.
Dvl2 and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body.
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
DIX domain mediates targeting to actin stress fibres and cytoplasmic vesicles in vivo
Results show that WIF1-mediated autophagy inhibits Wnt/betacatenin signaling by downregulating Dvl2, which contributes to the inhibition of the proliferation and the promotion of the apoptosis of nonsmall cell lung cancer cells.
The inactivation of Wnt3a reversed the effect of Dvl2 silencing. In conclusion, the results indicate that Dvl2 regulated osteogenic differentiation of SFBs in osteoarthritis.
Overexpression of dishevelled 2 is associated with metastasis in hepatocellular carcinoma.
FZD4 Tyrosine 250(2.39) is crucial for DVL2 interaction and DVL2 translocation to the plasma membrane.
we found that Wnt3a treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3. Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP domain in Wnt signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt/beta-catenin signaling.
Data show that RAP1B expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B interacted with DVL2 and activated Wnt/beta-catenin signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1-induced trans-activation of Snail, which promotes proliferation and metastasis.
The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR.
Elevated DVL2 expression is associated with drug resistance in colorectal cancer.
The interaction of Dvl2 with Dapper-1 is involved in the negative regulation of Wnt signaling.
APPL1 is a positive regulator of Dvl2-dependent transcriptional activity of AP-1.
CapZIP, which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP through binding to both ERK7 and CapZIP.
Different Dvl proteins (Dvl1, Dvl2, Dvl3) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt signalling, Dishevelled inhibits CSL transcription factors to regulate Notch signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt versus PCP signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 and mediates ephrinB1 signalling through downstream members of the PCP pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
Wnt11-induced polarized accumulation of Frizzled7 and Dishevelled at adherens junctions underlies the formation and maintenance of apicobasal cell polarity.
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells.
PTK7-mediated membrane localization of a dsh deletion mutant lacking PCP activity inhibits neural crest migration.
Data suggest that XDpr1a phosphorylation by CKIdelta/epsilon is dependent on the interaction of XDpr1a's PDZ-B domain with XDsh's PDZ domain, and that the phosphorylation state of XDpr1a determines whether it inhibits or activates Wnt signaling.
Dishevelled interacts with Lurap1 to regulate cellular polarisation during gastrulation.
demonstrate that during early zebrafish development Nkd1 does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog