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we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (zeige ROR2 Proteine), which influenced Ras Homology Family Member A (zeige CXCL14 Proteine) (RhoA (zeige RHOA Proteine)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (zeige ROCK1 Proteine)) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt (zeige WNT2 Proteine) signalling activation in colon cancer development.
Dpr1 (zeige DACT1 Proteine) promotes the ubiquitination of Dvl2 by pVHL (zeige VHL Proteine) and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 (zeige RAB35 Proteine) and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 (zeige DVL3 Proteine) have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard (zeige DULLARD Proteine) may play a role in the fine-tuning of WNT (zeige WNT2 Proteine) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp (zeige VANGL2 Proteine)/+) embryos did not exacerbate the Vangl2(Lp (zeige VANGL2 Proteine)/+) neuronal migration phenotype
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a (zeige WNT5A Proteine)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (zeige WNT2 Proteine) pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 (zeige STAU1 Proteine) coordinates myogenesis through the regulation of Dvl2 mRNA.
Overexpression of dishevelled 2 is associated with metastasis in hepatocellular carcinoma.
FZD4 (zeige FZD4 Proteine) Tyrosine 250(2.39) is crucial for DVL2 interaction and DVL2 translocation to the plasma membrane.
we found that Wnt3a (zeige WNT3A Proteine) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3 (zeige DVL3 Proteine). Our findings suggest a model of positive regulation of PKCzeta (zeige PRKCZ Proteine)-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Proteine) treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP domain in Wnt (zeige WNT2 Proteine) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
Data show that RAP1B (zeige RAP1B Proteine) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (zeige RAP1B Proteine) interacted with DVL2 and activated Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (zeige DVL1 Proteine), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
CapZIP (zeige RCSD1 Proteine), which has been shown to regulate ciliogenesis, is an ERK7 (zeige MAPK15 Proteine) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (zeige MAPK15 Proteine) phosphorylation of CapZIP (zeige RCSD1 Proteine) through binding to both ERK7 (zeige MAPK15 Proteine) and CapZIP (zeige RCSD1 Proteine).
Different Dvl proteins (Dvl1 (zeige DVL1 Proteine), Dvl2, Dvl3 (zeige DVL3 Proteine)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Proteine) signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L (zeige NEDD4L Proteine) is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt (zeige WNT2 Proteine) signalling, Dishevelled inhibits CSL (zeige SMPX Proteine) transcription factors to regulate Notch (zeige NOTCH1 Proteine) signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (zeige WNT2 Proteine) versus PCP (zeige PRCP Proteine) signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (zeige EFNB1 Proteine) and mediates ephrinB1 (zeige EFNB1 Proteine) signalling through downstream members of the PCP (zeige PRCP Proteine) pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
demonstrate that during early zebrafish development Nkd1 (zeige NKD1 Proteine) does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog