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FZD4 (zeige FZD4 Antikörper) Tyrosine 250(2.39) is crucial for DVL2 interaction and DVL2 translocation to the plasma membrane.
we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3 (zeige DVL3 Antikörper). Our findings suggest a model of positive regulation of PKCzeta (zeige PRKCZ Antikörper)-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP (zeige ZDHHC21 Antikörper) domain in Wnt (zeige WNT2 Antikörper) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
Data show that RAP1B (zeige RAP1B Antikörper) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (zeige RAP1B Antikörper) interacted with DVL2 and activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (zeige DVL1 Antikörper), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (zeige SFRP2 Antikörper) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
dishevelled 2 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2