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anti-Rat (Rattus) DVL2 Antikörper:
anti-Mouse (Murine) DVL2 Antikörper:
anti-Human DVL2 Antikörper:
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Cow (Bovine) Polyclonal DVL2 Primary Antibody für IHC, WB - ABIN2779458
Lee, Zhao, Moon, Yoon, Kim, An, Kwon, Hwang, Choi, Shim, Kim, Yang: Differential involvement of GABA system in mediating behavioral and neurochemical effect of acupuncture in ethanol-withdrawn rats. in Neuroscience letters 2008
Show all 2 Pubmed References
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (zeige ROR2 Antikörper), which influenced Ras Homology Family Member A (zeige CXCL14 Antikörper) (RhoA (zeige RHOA Antikörper)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (zeige ROCK1 Antikörper)) activity downstream of Dishevelled-2 (Dvl2).
Epsins are required for Dishevelled stability and Wnt (zeige WNT2 Antikörper) signalling activation in colon cancer development.
Dpr1 (zeige DACT1 Antikörper) promotes the ubiquitination of Dvl2 by pVHL (zeige VHL Antikörper) and mediates the protein aggregate-elicited autophagy initiation
Dvl2 binds to Rab35 (zeige RAB35 Antikörper) and activation is required for MCF-7 cell migration
Dvl-2 and Dvl-3 (zeige DVL3 Antikörper) have a widespread distribution in both the olfactory epithelium and olfactory bulb
Dullard (zeige DULLARD Antikörper) may play a role in the fine-tuning of WNT (zeige WNT2 Antikörper) signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage.
loss of Dvl2 function in Vangl2(Lp (zeige VANGL2 Antikörper)/+) embryos did not exacerbate the Vangl2(Lp (zeige VANGL2 Antikörper)/+) neuronal migration phenotype
Identification of a novel Wnt5a (zeige WNT5A Antikörper)-CK1varepsilon-Dvl2-Plk1 (zeige PLK1 Antikörper)-mediated primary cilia disassembly pathway.
These findings suggest that Wnt5a (zeige WNT5A Antikörper)-Ror-Dishevelled signaling constitutes a core noncanonical Wnt (zeige WNT2 Antikörper) pathway that is conserved through evolution and is crucial during embryonic development.
Dvl2 has an inhibitory role in myogenesis and Stau1 (zeige STAU1 Antikörper) coordinates myogenesis through the regulation of Dvl2 mRNA.
we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3 (zeige DVL3 Antikörper). Our findings suggest a model of positive regulation of PKCzeta (zeige PRKCZ Antikörper)-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl protein levels.
Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC.
Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP (zeige ZDHHC21 Antikörper) domain in Wnt (zeige WNT2 Antikörper) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
Data show that RAP1B (zeige RAP1B Antikörper) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (zeige RAP1B Antikörper) interacted with DVL2 and activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (zeige DVL1 Antikörper), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (zeige SFRP2 Antikörper) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 (zeige MLLT4 Antikörper) is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (zeige FOXE1 Antikörper)-induced trans-activation of Snail (zeige SNAI1 Antikörper), which promotes proliferation and metastasis.
CapZIP (zeige RCSD1 Antikörper), which has been shown to regulate ciliogenesis, is an ERK7 (zeige MAPK15 Antikörper) substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 (zeige MAPK15 Antikörper) phosphorylation of CapZIP (zeige RCSD1 Antikörper) through binding to both ERK7 (zeige MAPK15 Antikörper) and CapZIP (zeige RCSD1 Antikörper).
Different Dvl proteins (Dvl1 (zeige DVL1 Antikörper), Dvl2, Dvl3 (zeige DVL3 Antikörper)) and the composition of dishevelled-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Antikörper) signaling in Xenopus gastrulation.
these findings suggest that regulation of Dvl protein levels by NEDD4L (zeige NEDD4L Antikörper) is essential for convergent extension during early Xenopus embryogenesis.
findings reveal that, in response to Wnt (zeige WNT2 Antikörper) signalling, Dishevelled inhibits CSL (zeige SMPX Antikörper) transcription factors to regulate Notch (zeige NOTCH1 Antikörper) signalling and cell-fate decisions in vivo
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin (zeige Actbeta Antikörper).
The archenteron elongation is independent of Xdsh signaling, especially during the second half of gastrulation.
Subcellular localization is insufficient to account for the pathway specificity of Dishevelled in the canonical Wnt (zeige WNT2 Antikörper) versus PCP (zeige PRCP Antikörper) signaling cascades.
both Lgl and Dsh are required for normal apical-basal polarity of Xenopus ectodermal cells
Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 (zeige EFNB1 Antikörper) and mediates ephrinB1 (zeige EFNB1 Antikörper) signalling through downstream members of the PCP (zeige PRCP Antikörper) pathway during eye field formation.
The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.
demonstrate that during early zebrafish development Nkd1 (zeige NKD1 Antikörper) does not alter either endogenous or exogenous levels of Dvl2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
DSH homolog 2
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2
, dishevelled 2
, dishevelled, dsh homolog 2 (Drosophila)
, dishevelled 2 (homologous to Drosophila dsh)
, dishevelled homolog
, dishevelled 2, dsh homolog