anti-Cofilin1/2 (CFL1/2) Antikörper

Human Cofilin1/2 (CFL1/2) Interaktionspartner

1. During sperm capacitation, the F-actin severing proteins gelsolin and cofilin are inactive and they undergo activation prior to the acrosomal exocytosis. (Review)

2. High phosphorylated CFL1 expression is associated with dilated cardiomyopathy.

3. Cofilin 1 expression may be involved in the pathophysiology of bronchopulmonary dysplasia via dysregulation of actin binding proteins

4. In conclusion, deregulation of cytoskeleton dynamics through TESK1/CFL1 pathway underlies epithelial intestinal dysfunction in the small bowel mucosa of diarrhea-predominant irritable bowel syndrome, particularly in female patients.

5. High CFL1 expression is associated with malignant pancreatic lesions.

6. High CFL1 expression is associated with epithelial-mesenchymal transition of gastric cancer.

7. Cofilin-1 plays a dominant role in angiotensin-(1-7)-induced G0/G1 arrest and autophagy to maintain cellular homeostasis in human aortic endothelial cells

8. NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.

9. The enhancement of cancer cells invasion is dependent on CFL1, a known regulator of invadopodia maturation.

10. The present study demonstrates that miR-145 plays an important role in inhibiting cell migration by directly targeting PAK4, and identifies miR-145-PAK4-LIMK1-cofilin as a novel regulatory pathway that contributed to colorectal cancer metastasis.

11. D44 and RHOA are required for CFL1 phosphorylation and cell migration induced by CD74 in breast cancer cells.

12. Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.

13. Our study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer

14. Results suggest that the immune-complex (IC) of cofilin-1 in sera is a potentially attractive serum biomarker for the prognosis of pancreatic ductal adenocarcinoma (PDAC).

15. High cofilin expression is associated with adrenocortical tumor.

16. In advance urothelial cancer, overexpression of nuclear cofilin correlates with bladder cancer progression.

17. Report structural basis for noncanonical substrate recognition of cofilin-1/LIMK1 to regulation actin cytoskeleton dynamics.

18. STMN1,COF1 and PAIRBP1 thus represent proteins associated with proliferative and aggressive tumors of high grades, while TSP2 and POSTN were connected to low grade tumors with better prognosis

19. We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1) gene expressions in metabolic syndrome patients.

20. Therefore, miR-138/LIMK1/cofilin may be considered a potential therapeutic target for the treatment of non-small cell lung cancer