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Mouse (Murine) Transferrin Receptor 2 ELISA Kit für Sandwich ELISA - ABIN415732
Cheng, Zhou, Li, Liu, Wang, Zhang: The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice. in Food & function 2016
erythroid Tfr2 is essential for an appropriate erythropoietic response in iron-deficient anemia
These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin (zeige SLC40A1 ELISA Kits) and thus macrophage iron homeostasis
Tfr2 is a novel target gene for HNF4alpha (zeige HNF4A ELISA Kits), and hepatic HNF4alpha (zeige HNF4A ELISA Kits) plays a critical role in iron homeostasis.
There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia.
We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo (zeige EPO ELISA Kits) sensitivity.
We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.
These results support in vivo studies which suggest that Hfe (zeige HFE ELISA Kits) and Tfr2 can independently regulate hepcidin (zeige HAMP ELISA Kits).
we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis (zeige HFE ELISA Kits)
Double mutant mice lacking functional Hfe (zeige HFE ELISA Kits) or Tfr2 and Tmprss6 (zeige TMPRSS6 ELISA Kits) exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 (zeige TMPRSS6 ELISA Kits) demonstrating that Hfe (zeige HFE ELISA Kits) and Tfr2 are not substrates for Tmprss6 (zeige TMPRSS6 ELISA Kits).
Disruption of both Hfe (zeige HFE ELISA Kits) and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone.
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis (zeige HFE ELISA Kits) patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (zeige HFE ELISA Kits) (p.Tyr230Cys), and one mutation in the 5'-UTR (zeige UTS2R ELISA Kits) of HAMP (zeige HAMP ELISA Kits) gene (c.-25G>A)
TFR2 expression altered within 4h of HAMP (zeige HAMP ELISA Kits) treatment, while HFE (zeige HFE ELISA Kits) expression altered later at 24h and 48h, suggesting that TFR2 may function prior to HFE (zeige HFE ELISA Kits) in HAMP (zeige HAMP ELISA Kits) regulation.
Of the non-HFE (zeige HFE ELISA Kits) forms of iron overload, TFR2-, HFE2 (zeige HFE2 ELISA Kits)-, and HAMP (zeige HAMP ELISA Kits)-related forms are predicted to be rare, with pathogenic allele frequencies in the range of 0.00007 to 0.0005. Significantly, SLC40A1 (zeige SLC40A1 ELISA Kits) variants that have been previously associated with autosomal-dominant ferroportin (zeige SLC40A1 ELISA Kits) disease were identified in several populations (pathogenic allele frequency 0.0004), being most prevalent among Africans
Transferrin (zeige Tf ELISA Kits) facilitates the formation of DNA double-strand breaks (DNA-DSBs) via transferrin receptor TfR1 but not TfR2.
In line with a status of iron deficiency, gene expression studies suggested decreased expression of transferrin (zeige Tf ELISA Kits) and transferrin receptor 2 in non-alcoholic steatohepatitis livers
Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.
results suggest that down-regulation of CD81 (zeige CD81 ELISA Kits) by GRAIL (zeige RNF128 ELISA Kits) targets TfR2 for degradation
Polymorphisms of the TRF2 (zeige TERF2 ELISA Kits) gene may be associated with age-related macular degeneration occurrence, either directly or by modulation of risk factors.
The variants of rs2075674 and rs7385804 in TFR2 gene were not associated with coronary heart disease risk in a Chinese Han population.
Present findings support the hypothesis of a main role of the TFR2 gene in HH pathogenesis in those regions, such as Central-Southern Italy, where the p.C282Y frequency is low.
One novel SNPs was identified in TFR2 which tended to be associated (P < 0.013) with skeletal muscle iron content.
TfR2 is coexpressed with transferrin-a (zeige Tf ELISA Kits) in the liver of the zebrafish embryo. Knockdown of TfR2 fails to produce anemia or a morphologic defect.
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
transferrin receptor 2
, transferrin receptor protein 2-like
, transferrin receptor protein 2