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Suggest that lactoferrin and CD15 (zeige FUT4 Proteine) may serve as specific markers to corroborate a definitive diagnosis in septic cardiomyopathy.
These findings suggest that recombinant human lactoferrin (rhLF) supplementation benefits neonate bone health by modulating bone formation.
Biological-material-functionalized porous monoliths were prepared with lactoferrin and beta-cyclodextrin.
Lactoferrin SNPs were not independent risk factors for various components of the metabolic syndrome.
Significant associations were found between periodontitis and g. -20G> A (rs11362) and g. -44C> G (rs1800972) SNPs in DEFB1 (zeige DEFB1 Proteine) gene as well as p.Ala29Thr (rs1126477) and p.Lys47Arg (rs1126478) SNPs in LTF gene.
Strong correlations between the meconium concentrations of CP, LF and MPO (zeige MPO Proteine) indicate a possible role of these complementary proteins in maintaining homeostasis of the intrauterine environment of the fetus. CP, LF and MPO (zeige MPO Proteine) measured in meconium may serve as biomarkers for assessment of impairment of oxidative balance during intrauterine life with its potential impact on disease development in adulthood.
VEN-120 (recombinant human lactoferrin) reduced inflammation in murine models of inflammatory bowel disease [IBD], accompanied by increased Tregs in the intestinal lamina propria. Data provide a novel immunological mechanism by which VEN-120 modulates T cells to restrict inflammatory T cell-driven disease.
LTF (lactotransferrin/lactoferrin), and ETV7 (Ets variant 7 (zeige ETV7 Proteine)) were mainly related with cell apoptosis and immune responses.
Recombinant human lactoferrin to affect BCG (zeige SLC11A1 Proteine) and LPS (zeige IRF6 Proteine) stimulation of CD14thorn and CD16thorn monocyte derived macrophages, leading to modulation of cytokine production post stimulation.
CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 (zeige CD44 Proteine) and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin expression was upregulated (P < 0.0005).
Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production.
lactoferrin and glutamate receptor-interacting protein 1 (zeige GRIP1 Proteine) showed a twofold increase during the controlled internal drug release -induced estrous stage compared to the levels in non-estrous stage in bovine cervical mucus
Review of preclinical studies in piglets fed bovine lactoferrin demonstrating the role of lactoferrin in gastrointestinal and immune development and function.
Review of preclinical studies in piglets fed bovine lactoferrin demonstrating the role of lactoferrin in neurodevelopment and cognition.
Bovine lactoferrin SNPs -270T>C and -156A>G showed close linkage disequilibrium (r(2)=0.76). The SNP -190G>A showed a significant association with SCS (zeige TWIST1 Proteine), and individuals with genotype GG had higher SCS (zeige TWIST1 Proteine) than genotypes AG and AA.
Lf upregulated several canonical signaling pathways associated with neurodevelopment and cognition and influenced ~10 genes involved in the brain-derived neurotrophin (zeige BDNF Proteine) factor (BDNF (zeige BDNF Proteine)) signaling pathway.
Results from this study indicated the probable role played by Lactoferrin promoter to serve as candidate gene for mastitis susceptibility among indigenous and crossbred milch cattle.
Supplementation with lactoferrin (1,600 mg/kg per day) effectively suppressed the increase in transepidermal water loss, reduction in skin hydration, aberrant epidermal hyperplasia, and cell apoptosis induced by UV irradiation.
Bovine Lf can capture and terminate the cycle of ROS (zeige ROS1 Proteine) production by heme iron. Luminal iron binding properties of Lf might assist in regulating excess levels of stored iron and down-regulate ferritin (zeige FTL Proteine) production and associated pro-inflammatory signaling.
The results showed potent stimulation of the proliferative response of PBMC by bovine lactoferrin, associated with the induction of proinflammatory cytokines only in the case of colostral bovine lactoferrin.
Hepatic Ltf prevents hepatic steatosis through inhibition of dietary lipid uptake in radiation-induced NAFLD mouse model. We also suggest coumestrol as a drug candidate for prevention of NAFLD.
Data indicate that lactoferrin uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH (zeige GAPDH Proteine)).
Results show that LTF gene expression is downregulated in colorectal cancer tumors and its knock out in mouse model of colitis-associated colorectal dysplasia suggests its protective role in colorectal mucosal immunity and inflammation.
Data show that the expression of several genes encoding salivary antimicrobial proteins, such as secretory leukocyte peptidase inhibitor (SLPI (zeige SLPI Proteine)), S100A8 (zeige S100A8 Proteine), and lactotransferrin, was reduced due to myeloid differentiation dactor 88 (MyD88 (zeige MYD88 Proteine)) deficiency.
Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model.
We conclude that lactotransferrin represents a late stage differentiation marker of neutrophils, macrophages and distinct subtypes of dendritic cells.
The variations in lactoferrin expression levels during developmental stages may be related to its regulatory role in mouse mammary gland immunity.
the present work indicated that LF stimulated MC3T3-E1 preosteoblast differentiation mainly through LRP1 (zeige LRP1 Proteine)-independent PKA and p38 (zeige CRK Proteine) signaling pathways.
Studie indicate that in iCre knock-in line, the iCre is expressed from endogenous lactoferrin (Ltf) promoter.
administration of lactoferrin led to autopotentiated increased expression of the LTF gene. The decreased lactoferrin mRNA levels in association with obesity and diabetes were replicated in mice adipose tissue
lactoferrin was found in the cytoplasm of principal cells in the corpus and cauda of the epididymis in peri (zeige PLIN1 Proteine)- and post-pubertal, but not pre-pubertal stallions. Further, lactoferrin binds to sperm, suggesting a role for protection or regulation of sperm.
These data indicate that clinically normal skin of horses affected by CHS is not characterized by modified maintenance levels of lactoferrin mRNA.
this paper shows that recombinant lactoferrin peptide LF-6 produced with intein technology has both antibacterial and immunomodulatory activity in mice
We propose that lactoferrin functions in the immune defense of the small intestinal mucosa by targeting the population of T cells in the lamina propria
Involvement of HSP27 (zeige HSPB1 Proteine) and lactoferrin in porcine endometrium and neutrophils activity.
Growth performance of animal pups is enhanced by directly feeding the genetically engineered milk containing enriched pLF protein in transgenic mice.
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, growth-inhibiting protein 12
, neutrophil lactoferrin
, N lobe
, minisatellite 10r detected by probe MMS10
, allergen Gal d III
, ovotransferrin BB type
, ovotransferrin BC type
, ovotransferrin CC type
, serum transferrin