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anti-Mouse (Murine) Aconitase 1 Antikörper:
anti-Human Aconitase 1 Antikörper:
anti-Rat (Rattus) Aconitase 1 Antikörper:
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Human Polyclonal Aconitase 1 Primary Antibody für IP, WB - ABIN947527
Rupani, Connell: Transferrin receptor mRNA interactions contributing to iron homeostasis. in RNA (New York, N.Y.) 2016
Arabidopsis thaliana Polyclonal Aconitase 1 Primary Antibody für WB - ABIN488534
Bernard, Cheng, Zhao, Balk: An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. in Plant physiology 2009
Show all 4 Pubmed References
Human Monoclonal Aconitase 1 Primary Antibody für IP, ELISA - ABIN559748
Reuter, Reiermann, Wörner, Schröter, Edemir, Buck, Henning, Peter-Katalinic, Vollenbröker, Amann, Pavenstädt, Schlatter, Gabriëls: IF/TA-related metabolic changes--proteome analysis of rat renal allografts. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010
Iron increases turnover of ACO1 in kidney cells, while increasing aconitase (zeige ACO2 Antikörper) activity, suggesting that the apoprotein (zeige APOE Antikörper) (aconitase (zeige ACO2 Antikörper)-inactive) form is not exclusively responsible for turnover.
IL-6 (zeige IL6 Antikörper) likely up-regulates IRP1 and DMT1 (zeige SLC11A2 Antikörper) expression and down-regulates FPN1 (zeige SLC40A1 Antikörper) expression in BV2 (zeige DNAH9 Antikörper) microglial cells through JNK (zeige MAPK8 Antikörper) signaling pathways
Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 (zeige IDH1 Antikörper) and Aco1, enzymes involved in the TCA cycle, were elevated.
The Irp1-/- mice develop polycythemia and pulmonary hypertension, and suggesting that Irp1 plays an essential role in erythropoiesis and in the pulmonary and cardiovascular systems.
IRP1 and IRP2 (zeige IREB2 Antikörper) mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism
Aco1 KD in fully differentiated 3T3-L1 adipocytes decreased lipogenic, Idh1, Adipoq, and Glut4 gene expression.
impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (zeige SLC25A37 Antikörper)(gt/gt (zeige FABP6 Antikörper)) cells results in elevated IRP1 RNA-binding that attenuates ALAS2 (zeige ALAS2 Antikörper) mRNA translation and protoporphyrin accumulation
Data indicate that JTR-009, a benzimidazole, operated by preventing iron-regulatory protein-1 (IRP1) from binding to the iron-responsive element (IRE) in APP (zeige APP Antikörper) mRNA.
Human ACO1 is a moonlighting protein that has both aco (zeige ACO2 Antikörper)nitase enzyme activity as well as an mRNA binding function.
Aco1 is a moonlighting protein that has aconitase (zeige ACO2 Antikörper) activity as well as mRNA binding ability.
regulatory circuit involving FBXL5 (zeige FBXL5 Antikörper) and CIA (zeige ASF1A Antikörper) acts through both IRPs to control iron metabolism and promote optimal cell growth
Data suggest that Fe-S cluster of IRP1 plays role in sensing/regulating cellular iron homeostasis; IRP1 alternates between function as cytosolic aconitase [which contains Fe(4)-S(4) cluster in active-site cleft] and function as apoenzyme [which lacks Fe-S cluster] that binds to iron response element stem-loop structures present in several iron regulatory protein transcripts. [REVIEW]
The SNP rs7874815 in the ACO1 gene was strongly associated with survival in pancreatic cancer.
Our results confirm the observation that mitoNEET (zeige CISD1 Antikörper) is important in transferring the iron sulfur clusters to the cytosolic aconitase in living cells and the His-87 ligand in mitoNEET (zeige CISD1 Antikörper) plays important role in this process.
Data show that IRP1 suppressed TfR1/DMT1 (+IRE) expression, limited the cellular iron content and decreased lactate dehydrogenase (LDH) release induced by hypoxia.
These in vitro studies suggest that human GLRX3 (zeige GLRX3 Antikörper) is important for cytosolic Fe-S protein (zeige CDSN Antikörper) maturation.
SIRT3 (zeige SIRT3 Antikörper) overexpression decreases TfR1 (zeige TFRC Antikörper) expression by inhibiting IRP1 and represses proliferation in pancreatic cancer cells.
ACO1 gene expression was positively associated with adipogenic markers in subcutaneous and visceral adipose tissue.
ACO1 genetic variation is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy
MitoNEET (zeige CISD1 Antikörper) governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/IRP1.
Even though the base-specific RNA-binding residues are not part of the aconitase active site, their substitutions can affect the aconitase activity of holo-IRP1, positively or negatively.
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
aconitase 1, soluble
, cytoplasmic aconitate hydratase
, iron regulatory protein 1
, aconitase 1-like
, 1-Aminocyclopropane-1-carboxylic acid oxidase
, ACC oxidase 1
, ethylene-forming enzyme
, protein pTOM 13
, IRE-BP 1
, citrate hydro-lyase
, cytoplasmic aconitase
, iron-responsive element-binding protein 1
, IRE-binding protein 1
, Iron responsive element binding protein
, aconitate hydratase, cytoplasmic
, ferritin repressor protein
, iron-responsive element binding protein 1