anti-Human TNFAIP3 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended TNFAIP3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antikörper
  • tnfaip3
  • MGC82339
  • TNFAIP3
  • A20
  • OTUD7C
  • TNFA1P2
  • Tnfip3
  • TNF alpha induced protein 3
  • TNF alpha induced protein 3 S homeolog
  • tumor necrosis factor, alpha-induced protein 3
  • TNFAIP3
  • tnfaip3.S
  • Tnfaip3
Epitop
AA 80-103
35
14
5
4
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
103
67
64
6
2
1
1
Wirt
Kaninchen
72
25
6
Klonalität
Polyklonal
Konjugat
Dieser TNFAIP3 Antikörper ist unkonjugiert
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
74
37
36
31
29
27
19
12
10
6
3
2
2
2
Optionen
Hersteller
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Bilder

Produktnummer ABIN680938
$ 306.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN918067 IF (p) Alexa Fluor 555 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN918070 IF (p) Alexa Fluor 350 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN918069 IF (p) Alexa Fluor 647 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN918066 IF (p) Alexa Fluor 488 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN680941 IF (p) Cy3 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN680942 IF (p) Cy5 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN680943 IF (p) Cy5.5 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN680945 IF (p) FITC Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN680944 IF (p) Cy7 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2814996 IF (p) Alexa Fluor 594 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5011750 IF (p) Alexa Fluor 750 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5011749 IF (p) Alexa Fluor 680 Rabbit IgG AA 80-103 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antikörper
Epitop AA 80-103
(35), (14), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(103), (67), (64), (6), (2), (1), (1)
Wirt Kaninchen
(72), (25), (6)
Klonalität
Polyklonal
Konjugat Dieser TNFAIP3 Antikörper ist unkonjugiert
(4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(74), (37), (36), (31), (29), (27), (19), (12), (10), (6), (3), (2), (2), (2)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TNFAIP3 Antikörper

Target Details TNFAIP3 Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human TNFAIP3
Isotyp IgG
Plasmids, Primers & others

Target Details TNFAIP3

Produktdetails anti-TNFAIP3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Tnfaip3 (TNFAIP3 Antibody Abstract)
Hintergrund

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways, affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG, the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin, polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.

Subcellular location: Cytoplasm, Nucleus, Lysosome

Synonyms: A20, OTUD7C, TNFA1P2, Tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, OTU domain-containing protein 7C, Putative DNA-binding protein A20, Zinc finger protein A20, TNFAIP3

Gen-ID 7128
UniProt P21580
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response

Anwendungsinformationen

Produktdetails anti-TNFAIP3 Antikörper Target Details TNFAIP3 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TNFAIP3 Antikörper Target Details TNFAIP3 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-TNFAIP3 Antikörper Target Details TNFAIP3 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) (AA 80-103) antibody (ABIN680938) Formalin-fixed and paraffin embedded rat myocardium labeled with Anti-TNFAIP3 Polyclo...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) (AA 80-103) antibody (ABIN680938) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti TN...