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mean proportions of European ancestry differed significantly between the genotypes of the TLR1 (zeige TLR1 Proteine) (I602S) gene in a population of the Atlantic Forest, Sao Paulo, Brazil
Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation.
recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6.
TLR6 role in Kawasaki disease susceptibility in African American family
The mRNA levels of Toll-like receptors TLR2, 6, and 9 were significantly elevated in the Kawasaki disease (KD) patient group versus the healthy controls.
Significant correlations with atherosclerosis susceptibility were found for the toll like receptor 1 (TLR1 (zeige TLR1 Proteine)) rs5743551 polymorphism and toll like receptor 6 (TLR6) rs5743810 polymorphism.
Study concludes that genetic variation in the TLR10 (zeige TLR10 Proteine)-TLR1-TLR6 gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine). These studies provide new insight into the role of the TLR10 (zeige TLR10 Proteine)-TLR1-TLR6 gene cluster and the innate immune response to organic dust.
Studied the relationship between polymorphisms in MBL (zeige MBL2 Proteine), TLR1 (zeige TLR1 Proteine), TLR2 and TLR6 encoding genes and stimulated IFN-gamma (zeige IFNG Proteine) and IL-12 (zeige IL12A Proteine) ex vivo production in BCG (zeige SLC11A1 Proteine) osteitis survivors. Found that variant genotypes of the MBL2 (zeige MBL2 Proteine) gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma (zeige IFNG Proteine) production.
efficient method for preparation of the extracellular domain of human Toll-like receptor 6 (TLR6ED) in Escherichia coli using the bubbling cultivation method. Our preparation method improved the level of expression of TLR6ED into a soluble fraction as compared with typical cultivation using a rotary shaker. Circular dichroism (CD) experiments confirmed the structural formation of TLR6ED with secondary structure contents
Toll-like receptor 6 (TLR6) is significantly overexpressed in the hepatocytes of non-alcoholic fatty liver disease (NAFLD patients compared to their normal counterparts.
findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium
the cooperative role of TLR9 (zeige TLR9 Proteine) with TLR2 or TLR6 receptors in sensing Brucella, was determined.
Data suggest that the transmembrane domains of Tlr4 (zeige TLR4 Proteine) and Tlr6 have essential roles in Tlr4 (zeige TLR4 Proteine)/Tlr6/Cd36 (zeige CD36 Proteine) receptor multimerization and activation; disruption of receptor multimerization (here, using a recombinant peptide fragment from Tlr4 (zeige TLR4 Proteine) transmembrane domain) reduces secretion of proinflammatory mediators from microglia and ultimately rescues neurons from death.
TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition.
Dengue virus NS1 (zeige IVNS1ABP Proteine) protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection
Hepatic expression of Tlr6, but not that of Tlr8 (zeige TLR8 Proteine) is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 (zeige TLR8 Proteine) critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.
lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface.
Transmembrane oligomeric form of Vibrio cholerae cytolysin (zeige PRF1 Proteine) (VCC) triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages.
long-term exposure to nicotine up-regulated the expression of TLR4 (zeige TLR4 Proteine) and -6 via a JNK (zeige MAPK8 Proteine)-related pathway, causing an exaggeration of the LPS (zeige TLR4 Proteine)-induced local airway inflammation and increased airway hyperreactivity
In total, 20, 27, and 26 SNPs were detected in TLR1 (zeige TLR1 Proteine), TLR2, and TLR6, respectively; SNPs detected in TLR6 may represent species-specific function on the protein level in the wild boars and domestic pigs.
both TLR2 and TLR6 are important in the recognition of M. hyopneumoniae in porcine alveolar macrophages
phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 (zeige TLR10 Proteine) was different from those of TLR1 (zeige TLR1 Proteine) and TLR6
Variants in the TLR6 gene are associated with susceptibility to bovine TB.
TLR2, TLR1 (zeige TLR1 Proteine), and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
The expression analysis showed similar expression profiles for TLR1 (zeige TLR1 Proteine) and TLR6, which indicate a co-regulation of these two genes, TLR10 (zeige TLR10 Proteine) had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 (zeige TLR1 Proteine) and TLR6.
Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 (zeige PGLYRP1 Proteine) and Toll (zeige TLR4 Proteine)-like receptors 2 and 6.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
toll-like receptor 1 type 1
, toll-like receptor 16
, toll-like receptor1