anti-Maus TLR6 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended TLR6 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 6 (TLR6) Antikörper
  • TLR1
  • TLR16
  • CD286
  • TLR-6
  • toll-like receptor 1 family member A
  • toll like receptor 6
  • toll-like receptor 6
  • TLR1A
  • TLR6
  • Tlr6
Epitop
AA 340-380
25
18
12
11
10
10
9
9
7
7
6
6
5
5
5
4
3
3
3
3
2
2
1
Reaktivität
Human, Maus, Ratte (Rattus)
208
76
10
3
3
3
1
1
Wirt
Kaninchen
134
76
32
Klonalität
Polyklonal
Konjugat
Dieser TLR6 Antikörper ist unkonjugiert
22
18
14
8
7
5
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
129
102
101
84
54
22
16
16
6
5
3
2
2
1
1
Optionen
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Bilder

Produktnummer ABIN749573
$ 318.45
Zzgl. Versandkosten $45.00

General

Antigen Toll-Like Receptor 6 (TLR6) Antikörper
Epitop AA 340-380
(25), (18), (12), (11), (10), (10), (9), (9), (7), (7), (6), (6), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(208), (76), (10), (3), (3), (3), (1), (1)
Wirt Kaninchen
(134), (76), (32)
Klonalität
Polyklonal
Konjugat Dieser TLR6 Antikörper ist unkonjugiert
(22), (18), (14), (8), (7), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(129), (102), (101), (84), (54), (22), (16), (16), (6), (5), (3), (2), (2), (1), (1)
Pubmed 1 Publikation vorhanden
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Produktdetails anti-TLR6 Antikörper

Target Details TLR6 Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN749573) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human TLR6
Isotyp IgG
Plasmids, Primers & others

Target Details TLR6

Produktdetails anti-TLR6 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN749573) Bilder zurück nach oben
Antigen
Andere Bezeichnung Tlr6 (TLR6 Antibody Abstract)
Hintergrund

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Subcellular location: Extracellular

Synonyms: CD286, Toll-like receptor 6, TLR6

Gen-ID 10333
UniProt Q9Y2C9
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Handhabung Referenzen für anti-TLR6 Antikörper (ABIN749573) Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Referenzen für anti-TLR6 Antikörper (ABIN749573) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-TLR6 Antikörper (ABIN749573)

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Shmuel-Galia, Aychek, Fink, Porat, Zarmi, Bernshtein, Brenner, Jung, Shai: "Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis." in: The EMBO journal, Vol. 35, Issue 6, pp. 685-98, 2016

Bilder

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN749573) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-TLR6/CD286 Polyc...
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Rat splenocytes stained with Anti- TLR6/CD286 Polyclonal Antibody, PE-CY5.5 Conjugate...
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Rat splenocytes stained with Anti- TLR6/CD286 Polyclonal Antibody, PE-CY5.5 Conjugate...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-TLR6 Poly...
Western Blotting (WB) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Rat spleen lysates probed with TLR6 Polyclonal Antibody, unconjugated at 1:300 overn...
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Mouse splenocytes probed with TLR6 Polyclonal Antibody, Unconjugated at 1:100 for 30...
Western Blotting (WB) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) Mouse thymus lysates probed with TLR6 Polyclonal Antibody, unconjugated at 1:300 ove...
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 6 (TLR6) (AA 340-380) antibody (ABIN749573) A549 cells probed with TLR6 Polyclonal Antibody, Unconjugated at 1:100 for 30 minute...