anti-Human TLR6 Antikörper für Immunoprecipitation

Recommended TLR6 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 6 (TLR6) Antikörper
  • TLR1
  • TLR16
  • CD286
  • TLR-6
  • toll-like receptor 1 family member A
  • toll like receptor 6
  • toll-like receptor 6
  • TLR1A
  • TLR6
  • Tlr6
Reaktivität
Human
194
69
10
3
3
2
1
1
Wirt
Maus
136
72
14
Klonalität
Monoklonal
Konjugat
Dieser TLR6 Antikörper ist konjugiert mit PE
17
17
12
7
7
5
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
122
100
86
81
54
21
16
15
6
5
4
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Mehr erfahren

Produktnummer ABIN2192073
$ 560.76
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
17.302011 ABIN2192074 FACS IF IP PE Mouse Anmelden zum Anzeigen TLR6-127 1
17.302011 ABIN2192071 FACS IF IP Mouse Anmelden zum Anzeigen TLR6-127 1
10 ABIN2903145 IF/ICC IHC IP WB Rabbit AA 608-796 Anmelden zum Anzeigen Polyclonal 0
4 ABIN2663315 ICC FACS IF ICFC IP IHC WB PE Mouse IgG1 kappa Anmelden zum Anzeigen TLR6-127 4
1 ABIN603873 FACS IF IP Mouse IgG1 Anmelden zum Anzeigen 0
1 ABIN2751745 ELISA IHC IP WB FITC Rabbit IgG AA 195-225 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1106221 Func IF IHC (p) IP Mouse IgG1 Anmelden zum Anzeigen TLR6-127 1
1 ABIN2663316 ICC FACS IF ICFC IP IHC WB PE Mouse IgG1 kappa Anmelden zum Anzeigen TLR6-127 4
1 ABIN2376394 FACS IF IP Mouse IgG1 Anmelden zum Anzeigen 9G283 0
1 ABIN2747702 ELISA IHC IP WB Rabbit IgG AA 195-225 Anmelden zum Anzeigen Polyclonal 0
1 ABIN6027818 IF/ICC IHC IP WB Mouse Anmelden zum Anzeigen 0
1 ABIN5558471 ELISA IHC IP WB Biotin Rabbit Anmelden zum Anzeigen Polyclonal 0
-12.769841 ABIN4360302 FACS ICC IF IHC IHC (p) IP Mouse IgG1 Anmelden zum Anzeigen TLR6-127 0

General

Antigen Toll-Like Receptor 6 (TLR6) Antikörper
Reaktivität Human
(194), (69), (10), (3), (3), (2), (1), (1)
Wirt Maus
(136), (72), (14)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR6 Antikörper ist konjugiert mit PE
(17), (17), (12), (7), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
(122), (100), (86), (81), (54), (21), (16), (15), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR6 Antikörper

Target Details TLR6 Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN2192073) Bilder
Sterilität 0.2 μm filtered
Klon TLR6-127
Plasmids, Primers & others

Target Details TLR6

Produktdetails anti-TLR6 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN2192073) Bilder zurück nach oben
Antigen
Andere Bezeichnung Toll-Like Receptor 6 (TLR6 Antibody Abstract)
Hintergrund The monoclonal antibody TLR6.127 reacts with the human Toll-like receptor 6 (TLR6). Toll-like receptors (TLRs) are highly conserved throughout evolution. They play an essential role in initiating the innate immune response against infectious pathogens. In Drosophila, toll is required for anti-fungal response, while the related 18-wheeler is involved in antibacterial defence. In humans, ten members of the TLR family protein (TLR1 to TLR10) have been identified. TLRs recognize a wide variety of pathogen-associated molecular patterns from bacteria, viruses, and fungi and elicit a wide array of antimicrobial responses. Among TLRs, TLR6 is expressed on the cell surface of monocytes, monocyte- derived immature dendritic cells (iDCs), and neutrophils, but not on B, T or natural killer (NK) cells. Human TLR6 is a 796-aa type l transmembrane protein that is 74 % identical with mouse. It contains an N-terminal signal peptide, 19 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain called Toll/IL-1R homology domain, as seen in other TLRs. TLR6 function has been studied mainly in mouse cells. Constitutive expression of TLR6 activates both the nuclear factor kappa-B (NFK- B) and Jun N-terminal kinase (JNK) pathways. Studies in human cells revealed that TLR6 and TLR2 colocalize at the plasma membrane of monocytes. Human TLR6 recognizes diacylated lipoprotein and peptidoglycan at the cell surface cooperatively with human TLR2. Thus, coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptideoglycan and subsequent cellular activation in human cells. Aliases CD286
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Handhabung Referenzen für anti-TLR6 Antikörper (ABIN2192073) Bilder zurück nach oben
Applikations-hinweise For immunoprecipitation, immunofluorescence staining and flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity, in vitro dilutions have to be made according to the amounts of TLR6 to be inactivated.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Referenzen für anti-TLR6 Antikörper (ABIN2192073) Bilder zurück nach oben
Buffer PBS, containing 1 % bovine serum albumin and 0.02 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Haltbarkeit 12 months

Referenzen für anti-TLR6 Antikörper (ABIN2192073)

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Nakao, Funami, Kikkawa, Taniguchi, Nishiguchi, Fukumori, Seya, Matsumoto: "Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 3, pp. 1566-73, 2005