anti-Human TLR6 Antikörper für Functional Studies

Recommended TLR6 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 6 (TLR6) Antikörper
  • TLR1
  • TLR16
  • CD286
  • TLR-6
  • toll-like receptor 1 family member A
  • toll like receptor 6
  • toll-like receptor 6
  • TLR1A
  • TLR6
  • Tlr6
Reaktivität
Human
207
77
12
3
3
3
1
1
Wirt
Maus
134
75
32
Klonalität
Monoklonal
Konjugat
Dieser TLR6 Antikörper ist unkonjugiert
22
18
14
8
7
5
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Applikation
Functional Studies (Func), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
128
102
101
82
55
21
15
15
6
5
3
2
2
1
1
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Produktnummer ABIN1106221
$ 368.50
Zzgl. Versandkosten $45.00

General

Antigen Toll-Like Receptor 6 (TLR6) Antikörper
Reaktivität Human
(207), (77), (12), (3), (3), (3), (1), (1)
Wirt Maus
(134), (75), (32)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR6 Antikörper ist unkonjugiert
(22), (18), (14), (8), (7), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Functional Studies (Func), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(128), (102), (101), (82), (55), (21), (15), (15), (6), (5), (3), (2), (2), (1), (1)
Pubmed 1 Publikation vorhanden
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Produktdetails anti-TLR6 Antikörper

Target Details TLR6 Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN1106221) Bilder
Spezifität This antibody detects TLR6.
Kreuzreaktivität (Details) Species reactivity (tested):Human
Reinigung Protein G
Klon TLR6-127
Isotyp IgG1
Plasmids, Primers & others

Target Details TLR6

Produktdetails anti-TLR6 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR6 Antikörper (ABIN1106221) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD286 / TLR6 (TLR6 Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are highly conserved throughout evolution. They play an essential role in initiating the innate immune response against infectious pathogens. In Drosophila, toll is required for anti-fungal response, while the related 18-wheeler is involved in antibacterial defence. In humans, ten members of the TLR family protein (TLR1 to TLR10) have been identified. TLRs recognize a wide variety of pathogen-associated molecular patterns from bacteria, viruses, and fungi and elicit a wide array of antimicrobial responses. Among TLRs, TLR6 is expressed on the cell surface of monocytes, monocyte-derived immature dendritic cells (iDCs), and neutrophils, but not on B, T or natural killer (NK) cells. Human TLR6 is a 796-aa type l transmembrane protein that is 74 % identical with mouse. It contains an N-terminal signal peptide, 19 tandemly repeated extracellular leucine-rich motifs, and a cytoplasmic domain called Toll/IL-1R homology domain, as seen in other TLRs. TLR6 function has been studied mainly in mouse cells. Constitutive expression of TLR6 activates both the nuclear factor kappa-B (NFK-B) and Jun N-terminal kinase (JNK) pathways. Studies in human cells revealed that TLR6 and TLR2 colocalize at the plasma membrane of monocytes. Human TLR6 recognizes diacylated lipoprotein and peptidoglycan at the cell surface cooperatively with human TLR2. Thus, coexpression of TLR2 and TLR6 at the cell surface is crucial for recognition of diacylated lipopeptide and peptideoglycan and subsequent cellular activation in human cells.Synonyms: Toll-like receptor 6
Gen-ID 10333
NCBI Accession NP_006059
UniProt Q9Y2C9
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Handhabung Referenzen für anti-TLR6 Antikörper (ABIN1106221) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Referenzen für anti-TLR6 Antikörper (ABIN1106221) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-TLR6 Antikörper (ABIN1106221)

Produktdetails anti-TLR6 Antikörper Target Details TLR6 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Nakao, Funami, Kikkawa, Taniguchi, Nishiguchi, Fukumori, Seya, Matsumoto: "Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 3, pp. 1566-73, 2005