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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
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Authors firstly uncovered that TLR4/NFkappaB (zeige NFKB1 Proteine) mediated inflammation signaling and miR (zeige MLXIP Proteine)-146a participated in ART-related preterm birth patients, which suggests that importance of TLR4/NFkappaB (zeige NFKB1 Proteine)/miR (zeige MLXIP Proteine)-146a signaling in clinical interventions and biomarkers of ART-related perinatal or neonatal outcomes.
Expression of X-linked Toll-like receptor 4 signaling gene IRAK1 (zeige IRAK1 Proteine) was significantly elevated in female neonates vs. male neonates.
Positive rates of iNOS (zeige NOS2 Proteine) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3 (zeige TLR3 Proteine), TLR4, TLR7 (zeige TLR7 Proteine), TLR8 (zeige TLR8 Proteine), NF-kappaB (zeige NFKB1 Proteine) p65 (zeige GORASP1 Proteine), and iNOS (zeige NOS2 Proteine) in cervical epithelial cells were higher in CC group than in other groups.
Prolonged hypertension influences peripheral monocyte TLR4 expression and IL-17A (zeige IL17A Proteine) serum levels
TLR4-stimulated oral keratinocytes inhibited the proliferation of oral lichen planus CD4 (zeige CD4 Proteine)(+) T cells and CD8 (zeige CD8A Proteine)(+) T cells, and simultaneously prompted their apoptosis.
Reduced expression of caveolin-1 (zeige CAV1 Proteine) in monocytes could aggravate the TLR4-mediated inflammatory cascade
the role of TLR4 in angiogenesis could be of value in various settings related to tissue repair and tissue engineering. Moreover, since LPS (zeige IRF6 Proteine) and TLR4 agonists improve angiogenesis and osteogenesis, TLR4 agonists (endogenous or synthetic) could be used for angiogenesis intervention in vivo.
PTX treatment of THP-1 macrophages for 1 h induced marked intranuclear translocation of NF-kappaB p65. Low-dose PTX inhibited the M2 phenotype and induced the M1 phenotype via TLR4 signaling, suggesting that low-dose PTX can alter the macrophage phenotype, whereas clinical doses can kill cancer cells. These results suggest that the anticancer effects of PTX are due both to its cytotoxic and immunomodulatory activities
recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6.
Upregulation of TLR-4 on CD14 (zeige NDUFA2 Proteine)(++)CD16 (zeige CD16 Proteine)(+)monocytes might be associated with coronary plaque vulnerability in patients with stable angina pectoris.
Forsythoside A exerts an anti-endotoxin effect by blocking the LPS/TLR4 signaling pathway and inhibiting Tregs in vitro.
data suggest that S100A8 (zeige S100A8 Proteine)/A9 acts directly on BV-2 microglial cells via binding to TLR4 and RAGE (zeige AGER Proteine) on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) activity in BV-2 microglial cells.
Vitamin K2 can inhibit intimal calcification of aortic artery induced by high-fat diet in ApoE(-/-) mice via suppression of TLR2/4 expression.
Endotoxaemia enhanced early venous thrombosis occurs in a TLR-4 and ICAM-1 (zeige ICAM1 Proteine) dependent fashion, and is potentiated by neutropenia.
TLR4-independent lipopolysaccharide uptake is promoted by kukoamine B in hepatocytes
This study provides new molecular insight into the ability of miR (zeige MLXIP Proteine)-29a to inhibit TLR2 and TLR4 signaling, which thus slows the progression of cholestatic liver deterioration.
Hyperin inhibited lipopolysaccharide-induced inflammatory response in acute kidney injury by inhibiting TLR4 and NLRP3 (zeige NLRP3 Proteine) signaling pathways.
tissue damage induced NADPH oxidase (zeige NOX1 Proteine) activation and increased the release of reactive oxygen species via cold-inducible RNA-binding protein (CIRP (zeige CIRBP Proteine))-TLR4-MyD88 (zeige MYD88 Proteine) signaling.
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha (zeige NR1H3 Proteine) dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts, thereby attenuating LPS mediated inflammatory response
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (zeige IL8 Proteine) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (zeige CD14 Proteine) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige SYT1 Proteine)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (zeige NFKB1 Proteine) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (zeige ICAM1 Proteine).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (zeige ACSM3 Proteine) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (zeige ACSM3 Proteine).
The TWEAK (zeige TNFSF12 Proteine)-independent Fn14 (zeige TNFRSF12A Proteine) activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (zeige MAMLD1 Proteine) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (zeige IRF6 Proteine) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (zeige CD180 Proteine)/MD1 (zeige LY86 Proteine) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (zeige CLPTM1 Proteine), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (zeige HPSE Proteine) axis induced by LPS (zeige IRF6 Proteine) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (zeige LY96 Proteine) and CD14 (zeige CD14 Proteine) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (zeige LY96 Proteine) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein