anti-Ratte (Rattus) TLR4 Antikörper für Immunocytochemistry

Recommended TLR4 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 4 (TLR4) Antikörper
  • ARMD10
  • CD284
  • TLR-4
  • TOLL
  • Lps
  • Ly87
  • Ran/M1
  • Rasl2-8
  • toll like receptor 4
  • toll-like receptor 4
  • TLR4
  • Tlr4
Epitop
pSer800
59
30
28
25
16
16
15
15
14
13
11
9
8
8
7
6
5
5
5
5
5
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
556
274
173
94
72
72
64
27
12
9
4
2
1
1
Wirt
Kaninchen
339
273
47
8
Klonalität
Polyklonal
Konjugat
Dieser TLR4 Antikörper ist unkonjugiert
49
47
47
23
15
14
13
10
9
9
8
6
6
6
6
6
6
6
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
394
341
186
137
129
123
98
92
34
32
27
26
26
21
20
16
14
8
7
4
4
3
2
1
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN6270322
$ 450.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
14.5 ABIN6269449 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 3
10 ABIN1173522 ICC IHC WB Rabbit IgG AA 49-247 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1173525 ICC IF IHC WB FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Toll-Like Receptor 4 (TLR4) Antikörper
Epitop pSer800
(59), (30), (28), (25), (16), (16), (15), (15), (14), (13), (11), (9), (8), (8), (7), (6), (5), (5), (5), (5), (5), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(556), (274), (173), (94), (72), (72), (64), (27), (12), (9), (4), (2), (1), (1)
Wirt Kaninchen
(339), (273), (47), (8)
Klonalität
Polyklonal
Konjugat Dieser TLR4 Antikörper ist unkonjugiert
(49), (47), (47), (23), (15), (14), (13), (10), (9), (9), (8), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
(394), (341), (186), (137), (129), (123), (98), (92), (34), (32), (27), (26), (26), (21), (20), (16), (14), (8), (7), (4), (4), (3), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR4 Antikörper

Target Details TLR4 Anwendungsinformationen Handhabung Bilder
Spezifität Phospho-TLR4( Ser800) Antibody detects endogenous levels of TLR4.
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human TLR4 around the phosphorylation site of Ser800.
Isotyp IgG
Plasmids, Primers & others

Target Details TLR4

Produktdetails anti-TLR4 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung TLR4 (TLR4 Antibody Abstract)
Hintergrund

Description: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).

Gene: TLR4

Molekulargewicht 100kDa
Gen-ID 7099
UniProt O00206
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR4 Antikörper Target Details TLR4 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:500-1:2000 IHC 1:50-1:200 IF 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR4 Antikörper Target Details TLR4 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol..
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months

Bilder

Produktdetails anti-TLR4 Antikörper Target Details TLR4 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) ABIN6270323 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was form...
Immunohistochemistry (IHC) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) ABIN6270323 at 1/100 staining rat liver tissue sections by IHC-P. The tissue was form...
Immunohistochemistry (IHC) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) ABIN6270323 at 1/100 staining human gastric cancer tissue sections by IHC-P. The tiss...
Immunohistochemistry (IHC) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) ABIN6270323 at 1/100 staining human liver tissue sections by IHC-P. The tissue was fo...
Western Blotting (WB) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) Western blot analysis of extracts from Hela, using Phospho-TLR4(Ser800) Antibody.
Immunofluorescence (fixed cells) (IF/ICC) image for anti-Toll-Like Receptor 4 (TLR4) (pSer800) antibody (ABIN6270322) ABIN6270323 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilize...