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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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5.5 | ABIN917904 | IF (cc) IF (p) | Alexa Fluor 488 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 1 | |
1 | ABIN917903 | IF (cc) IF (p) | Alexa Fluor 350 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN917905 | IF (cc) IF (p) | Alexa Fluor 555 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN917902 | IF (cc) IF (p) | Alexa Fluor 647 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN736495 | IF (cc) IF (p) | Cy5 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN736496 | IF (cc) IF (p) | Cy5.5 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN736494 | IF (cc) IF (p) | Cy3 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN736498 | IF (cc) IF (p) | FITC | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN736497 | IF (cc) IF (p) | Cy7 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN2809068 | IF (cc) IF (p) | Alexa Fluor 594 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN5011661 | IF (cc) IF (p) | Alexa Fluor 680 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 | |
1 | ABIN5011662 | IF (cc) IF (p) | Alexa Fluor 750 | Rabbit | IgG | AA 780-830 | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Toll-Like Receptor 4 (TLR4) Antikörper |
Epitop | AA 780-830 Alternativen |
Reaktivität | Rind (Kuh), Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser TLR4 Antikörper ist unkonjugiert Alternativen |
Applikation |
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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12 Publikationen vorhanden |
Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-TLR4 AntikörperTarget Details TLR4 Anwendungsinformationen Handhabung Referenzen für anti-TLR4 Antikörper (ABIN736491) Bilder |
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Reinigung | Purified by Protein A. |
Immunogen | KLH conjugated synthetic peptide derived from rat TLR4 |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details TLR4Produktdetails anti-TLR4 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR4 Antikörper (ABIN736491) Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | TLR4 (TLR4 Antibody Abstract) |
Hintergrund |
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Subcellular location: Cytoplasm Synonyms: Lps, Ly87, Ran/M1, Rasl2-8, Toll-like receptor 4, CD284, Tlr4 |
Gen-ID | 21898 |
UniProt | Q9QUK6 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades |
AnwendungsinformationenProduktdetails anti-TLR4 Antikörper Target Details TLR4 Handhabung Referenzen für anti-TLR4 Antikörper (ABIN736491) Bilder zurück nach oben |
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Applikations-hinweise |
WB 1:100-1000 IHC-P 1:100-500 IF(IHC-P) 1:50-200 IF(ICC) 1:50-200 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-TLR4 Antikörper Target Details TLR4 Anwendungsinformationen Referenzen für anti-TLR4 Antikörper (ABIN736491) Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Lagerung | -20 °C |
Informationen zur Lagerung | Store at -20°C |
Haltbarkeit | 12 months |
Referenzen für anti-TLR4 Antikörper (ABIN736491)Produktdetails anti-TLR4 Antikörper Target Details TLR4 Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Kulhankova, Kinney, Stach, Gourronc, Grumbach, Klingelhutz, Salgado-Pabón: "The Superantigen Toxic Shock Syndrome Toxin-1 Alters Human Aortic Endothelial Cell Function." in: Infection and immunity, 2018 Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human). Harasymowicz, Clement, Azfer, Burnett, Salter, Simpson: "Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients With Osteoarthritis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 69, Issue 7, pp. 1396-1406, 2017 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Human). Weitere Details: Sample: adipose Xu, Zheng, Liu, Li, Yang, Shang: "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 44, Issue 6, pp. 2091-2104, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: brain Arfian, Muflikhah, Soeyono, Sari, Tranggono, Anggorowati, Romi: "Vitamin D Attenuates Kidney Fibrosis via Reducing Fibroblast Expansion, Inflammation, and Epithelial Cell Apoptosis." in: The Kobe journal of medical sciences, Vol. 62, Issue 2, pp. E38-44, 2016 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: kidney Kawakita, Fujimoto, Liu, Nakano, Nakatsuka, Suzuki: "Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice." in: Molecular neurobiology, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: brain Wang, Shi, Lv, Xu, Li, Ge, Xiao, Geng, Liu: "Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-?B Activation in Microglial Cells." in: Inflammation, 2015 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Namisaki, Noguchi, Moriya, Kitade, Aihara, Douhara, Nishimura, Takeda, Okura, Kawaratani, Takaya, Seki, Yoshiji: "Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis." in: Journal of gastroenterology, 2015 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Intestine Yang, Wang, Zhang, Yang, Lu, Zhang, Li, Zhang, Li: "Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-?B signaling pathway in isoproterenol-induced myocardial hypertrophy." in: Journal of ethnopharmacology, Vol. 150, Issue 3, pp. 1062-70, 2014 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: left ventricle and neonatal cardiomyocytes Chen, Yu, Fan, Bian, Ma, Lu, Jin: "Sargassum fusiforme polysaccharide activates nuclear factor kappa-B (NF-?B) and induces cytokine production via Toll-like receptors." in: Carbohydrate polymers, Vol. 105, pp. 113-20, 2014 (Probematerial (Species): Rat (Rattus)). Xing, Zheng, Zhang, Wang, Xing: "Relationship between toll-like receptor 4 levels in aorta and severity of atherosclerosis." in: The Journal of international medical research, Vol. 42, Issue 4, pp. 958-965, 2014 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Human). Weitere Details: Sample: Kidney Takanashi, Tomosada, Villena, Murata, Takahashi, Chiba, Tohno, Shimazu, Aso, Suda, Ikegami, Itoh, Kawai, Saito, Alvarez, Kitazawa: "Advanced application of bovine intestinal epithelial cell line for evaluating regulatory effect of lactobacilli against heat-killed enterotoxigenic Escherichia coli-mediated inflammation." in: BMC microbiology, Vol. 13, pp. 54, 2013 Tang, Zhou, Wang, Zhang, Wang, Li, Huang: "Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts." in: Archives of oral biology, Vol. 56, Issue 10, pp. 1064-72, 2011 (Probematerial (Species): Human). |
BilderProduktdetails anti-TLR4 Antikörper Target Details TLR4 Anwendungsinformationen Handhabung Referenzen für anti-TLR4 Antikörper (ABIN736491) zurück nach oben |
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Bilder des Herstellers |
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