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anti-Human TLR4 Antikörper:
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Human Monoclonal TLR4 Primary Antibody für ChIP, CyTOF - ABIN252522
Kessel, Toubi, Pavlotzky, Mogilner, Coran, Lurie, Karry, Sukhotnik et al.: Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by ... in Clinical and experimental immunology 2008
Show all 86 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für BP, CyTOF - ABIN4360113
Rallabhandi, Bell, Boukhvalova, Medvedev, Lorenz, Arditi, Hemming, Blanco, Segal, Vogel: Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 48 Pubmed References
Human Polyclonal TLR4 Primary Antibody für IHC (p), WB - ABIN4886746
Li, Qian, Ju, Wang: Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus. in Oncology letters 2014
Show all 29 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für FACS - ABIN252065
Konno, Wakabayashi, Akashi-Takamura, Ishii, Kobayashi, Takahashi, Kusumoto, Saitoh, Yoshizawa, Miyake: A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. in Biochemical and biophysical research communications 2005
Show all 26 Pubmed References
Human Monoclonal TLR4 Primary Antibody für BP, CyTOF - ABIN4360167
Degraaf, Zasłona, Bourdonnay, Peters-Golden: Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. in American journal of respiratory cell and molecular biology 2014
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für FACS - ABIN4360117
Mempel, Voelcker, Köllisch, Plank, Rad, Gerhard, Schnopp, Fraunberger, Walli, Ring, Abeck, Ollert et al.: Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet ... in The Journal of investigative dermatology 2003
Show all 23 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für BP, CyTOF - ABIN4360119
Basak, Pathak, Bhattacharyya, Mandal, Pathak, Kundu et al.: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori ... in The Journal of biological chemistry 2005
Show all 23 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für FACS, ICC - ABIN4360164
Cognasse, Hamzeh, Chavarin, Acquart, Genin, Garraud: Evidence of Toll-like receptor molecules on human platelets. in Immunology and cell biology 2005
Show all 21 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody für BP, ELISA - ABIN4360158
Scheel, Papavlassopoulos, Blunck, Gebert, Hartung, Zähringer, Seydel, Schromm: Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. in Infection and immunity 2006
Show all 18 Pubmed References
Human Monoclonal TLR4 Primary Antibody für FACS - ABIN4360193
Zanoni, Navone, Lunardi, Tridente, Bason, Sivori, Beri, Dolcino, Valletta, Corrocher, Puccetti: In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. in PLoS medicine 2006
Show all 16 Pubmed References
Interaction of Notch signaling pathway with TLR4 can promote the function of CD14(+) monocytes in chronic hepatitis C patients.
TLR4 may have a role in contributing to the antitumor effect of paclitaxel
The authors report here for the first time the association of TLR4 polymorphism with hepatitis E and suggest that TLR 4 hyporesponsiveness during hepatitis E virus infection might be related to its polymorphism.
The study demonstrates that TLR4 gene silencing inhibits proliferation and induces apoptosis of MCF-7 and MDA-MB-231 cells.
TLR4 was indicated as miR-181a target and the binding correlation between them was validated by dual-luciferase reporter assay
The extracellular HMGB1 induced the migration of PMBC-derived macrophages toward HUVECs in a TLR4-dependent manner. Our results suggested that ox-LDL promoted HUVECs apoptosis and macrophage recruitment by regulating caveolin-1 phosphorylation.
The authors show that TLR4 is not a receptor for long-chain saturated fatty acids (lcSFAs), but rather that TLR4-dependent priming alters cellular metabolism, gene expression, lipid metabolic pathways, and membrane lipid composition, changes that are necessary for lcSFA-induced inflammation.
The TLR4 Asp299Gly heterozygous genotype (OR=2.160; p=0.004) and the mutant allele G (OR=2.051; p=0.002) was higher in HIV-1 infection than healthy controls and also in stage I (OR=2.559; p=0.034) compared to different clinical stages of infection The TLR4 (Asp299Gly) SNP is a risk factor in HIV-1 disease susceptibility.
Study demonstrates a role for the high mobility group box 1 - toll like receptor 4 pathway at the syncytium layer and suggests involvement in placental inflammation and preeclampsia
The effects were inhibited by blocking Toll-like receptor 4 pathway.
The protective effect of miR-6869-5p from colorectal carcinogenesis was dependent on TLR4/NF-kappaB signaling pathway.
TLR4 is prominently expression in kidney glomerulus in antineutrophil cytoplasmic antibody-associated vasculitis and correlates with renal injury.
we observed major alterations in the HMGB1-TLR4 signaling axis. Functional analysis also showed that HMGB1 expression is important for the proliferative and tumorigenic potential of cervical cancer cell lines.
Cordyceps militaris protected against chronic kidney disease progression by affecting the TLR4/NF-kappaB lipid and redox signaling pathway via cordycepin.
In esophageal cancer patients with lymph node metastasis, a tendency toward higher protein concentrations of tumor TLR-4 was observed.
the importance of BRD4/B7-H3/TLR4 pathway
Study found that decreased TLR4 expression levels are associated with enhanced malignant features in human cutaneous squamous cell carcinoma (SCC) tissue samples and cultured SCC cell line. TLR4 may thus play an important antitumor role in suppressing aggressive cutaneous SCC cellular behaviors.
Results show that mRNA expression of TLR4 was upregulated in CD14(+) monocytes obtained from coronary artery disease (CAD patients. Its expression is regulated by RFX1 through epigenesist process.
Studied association of toll like receptor 4 (TLR4) mRNA levels as well as tumor necrosis factor-alpha (TNF-a) single nucleotide polymorphisms (SNPs) and TLR4 SNPs with preterm birth in a rural Indian population; found increased maternal TLR4 mRNA levels may be associated with the risk of preterm birth.
immature DCs and toll-like receptor 4 (TLR4) stimulated DCs had similar internalization capacity and were both able to cross-present antigen targeted via DC-SIGN. Interestingly, simultaneous triggering of TLR4 and DC-SIGN on DCs resulted in the translocation of cargo to the cytosol, leading to proteasome-dependent processing and increased CD8(+) T cell activation.
the absence of TLR4, a receptor for Graphene oxide (GO), failed to downregulate, and instead partially enhanced the anti-inflammatory activity of GO against a-GalCer-elicited responses, implying negative effects of TLR4 signaling on the anti-inflammatory properties of GO
we uncovered that miR-182-5p played significant roles in Atherosclerosis through inhibiting oxidative stress and apoptosis via inactivating TLR4 expression.
These findings implied for the first time that the overexpression of miR-874 repressed glucose-triggered podocyte injury through targeting TLR4 and suggested that miR-874/TLR4 axis might represent a pathological mechanism of Diabetic nephropathy (DN) .
Enteric nerve density and proportion of nitrergic nerves were similar in WT and TLR2/4 (-/-) distal colon. These data suggest an involvement of TLRs in opioid pharmacodynamics and thus a potential interventional target for Opioid-induced bowel dysfunction (OIBD).
Heme Oxygenase-1 Protects the Liver from Septic Injury by Modulating TLR4-Mediated Mitochondrial Quality Control.
changes in the expression of autistic and cytokine genes were unaffected in the offspring of ethanol-fed TLR4(-/-) dams
WISP1 contributes to hepatic steatosis and skeletal muscle insulin resistance through a TLR4-activated inflammation/JNK signaling pathway.
Reduction of TLR4 by miR-448 prevents Lipopolysaccharide + Interferon Gamma-induced M1 polarization in macrophage
TLR4-deficiency protects against combined deleterious effects of a high fat diet and ageing through a reduced expression of inflammatory products in both insulin sensitive tissues and pancreatic islets.
Our data collectively indicate a role for TLR4-mediated autophagy in cardiac remodeling and contractile dysfunction in aging through a HDAC1-NCoR1-dependent mechanism.
TH17-dependent inflammation in the lungs can be sustained by persistent TLR4-mediated activation of lung dendritic cells.TLR4 antagonism might be an effective treatment for chronic lung conditions, such as asthma and interstitial lung disease, that are characterized by TH17 cell and neutrophilic inflammation.
Findings suggest that stx11 regulates the stimulus-dependent transport of TLR4 to the plasma membrane by cooperating with SNAP-23 in macrophages. Our results clarify the regulatory mechanisms underlying intracellular transport of TLR4 and have implications for microbial pathogenesis and immune responses.
TLR4 receptor mediates the acute renal vasoconstrictive effects of heme in vivo and the proinflammatory effects on renal epithelial cells in vitro, the TLR4 receptor does not mediate heme-induced anti-inflammatory responses in vitro or heme-induced proinflammatory effects in vivo.
These results indicated that TLR4-dependent autophagy regulates microglial polarization and induces ischemic white matter damage via STAT1/6 pathway.
Data show only the absence of toll-like receptor 2 (TLR2) but not toll-like receptor 4 (TLR4) in mice exacerbated the renal dysfunction, tissue injury and mortality rate.
Resistin and TLR4 are part of a new regulatory pathway of neuronal autophagy.
PRDX6 inhibits the neurogenesis of neural precursor cells through TLR4-dependent downregulation of WDFY1.
the TLR4 endocytosis was significantly higher in the cortex of aged mice and Alzheimer's disease model mice brains, proposing a significant link between the age-related reduction of plasmalogens and microglial activation.
the PXR-TLR4 signaling pathway may have a role in intestinal inflammation in an experimental model of necrotizing enterocolitis
SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population
This research reveals the effectiveness of LTF/EcoRI and TLR4/AluI loci as candidates for reproductive performance assessment in Holstein cattle.
Two single nucleotide polymorphisms had significant effects on the milk production for Chinese Holstein, and these SNP could be used for molecular marker-assisted selection of milk production.
PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells.
Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes.
Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.
Findings indicate that intervertebral disc (IVD) cells constitutively express TLR4.
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (p65) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB expression, then inhibiting the release of mediators of inflammation as ICAM-1.
SNPs associated with incidence of digestive disorders
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH.
Data suggest that expression of TLR4 in intestinal mucosa can be regulated by dietary factors; here, flaxseed oil down-regulates expression of TLR4 in piglet model of necrotizing enterocolitis.
Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB.
The TWEAK-independent Fn14 activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105/MD1 in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14, is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA axis induced by LPS challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The complete coding sequence of TLR4 gene in Min pig and 3 variants with single point mutations were obtained.
The relationship between TLR4 single nucleotide polymorphisms and the transcription levels of cytokines indicate that they are related to the modulation of the cytokine mediated immune response in pigs.
An alteration from cysteine to tryptophan at position 506 (C506W) caused loss of ability to induce nuclear factor-kappaB activation after lipid A stimulation.
These findings showed that TLR4 takes part in airway mucosal defense systems as a unique exogenous potentiator of electrolyte-water secretion from acinar cells, and that NO/cGMP/cGKsignaling is involved in this rapid TLR4 signaling pathway.
Three new alleles were isolated for exon 1 of the TLR4 gene.
similarity in TLR4 staining in macrophages, epithelium and vascular endothelium among dog, pig and cattle
A high level of conservation of TLR4 gene size and sequence, especially for the two last exons and particularly in the sequence corresponding to the LRRs and TIR domain, is observed between species
expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive
This study provides the basis for comparative investigations into the impact of different stimuli on the cellular expression of TLRs 2, 4 and 6 in order to find out if TLRs are involved in the pathogenesis of endometrial diseases and may help to understand as to why some mares develop persistent endometritis.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 and CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein