anti-Human TLR3 Antikörper für Immunofluorescence

Recommended TLR3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 3 (TLR3) Antikörper
  • CD283
  • IIAE2
  • AI957183
  • zgc:123006
  • toll like receptor 3
  • toll-like receptor 3
  • TLR3
  • Tlr3
  • tlr3
Reaktivität
Human
280
207
64
45
5
4
3
2
2
2
1
1
1
1
1
Wirt
Maus
201
122
39
3
2
Klonalität
Monoklonal
Konjugat
Dieser TLR3 Antikörper ist konjugiert mit Biotin
33
30
24
16
10
8
7
6
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
240
143
105
90
67
43
40
37
13
13
12
7
5
4
1
1
1
Optionen
Hersteller
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Produktnummer ABIN2191974
$ 407.22
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
21.136078 ABIN2191973 FACS IF IHC (p) FITC Mouse IgG1 Anmelden zum Anzeigen TLR3-7 6
21.136078 ABIN2191972 FACS IF IHC (p) Mouse IgG1 Anmelden zum Anzeigen TLR3-7 6
20.754787 ABIN615251 EIA IF IHC (p) WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
19 ABIN531989 FACS IF IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen 40C1285-6 8
17.754787 ABIN615847 IF IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
14.158017 ABIN4360082 FACS ICC IF IHC IHC (p) IP WB Mouse IgG1 kappa Anmelden zum Anzeigen 40C1285-6 65
10 ABIN604951 ICC IF IHC IHC (p) WB Rabbit AA 514-657 Anmelden zum Anzeigen Polyclonal 0
7 ABIN2663312 ICC FACS IF PE Mouse IgG2a kappa Anmelden zum Anzeigen TLR-104 8
7 ABIN1740109 ICC IF IHC (p) WB Rabbit IgG AA 514-657 Anmelden zum Anzeigen Polyclonal 0
7 ABIN187555 FACS IF IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen 40C1285-6 0
7 ABIN535341 FACS IF IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen 40C1285 0
1 ABIN5555334 EIA IF WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN5555333 EIA IF WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN1106214 Func IHC (fro) IF IHC (p) IP WB FITC Mouse IgG1 Anmelden zum Anzeigen TLR3-7 4
1 ABIN1106212 Func IHC (fro) FACS IF IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen TLR3-7 5
1 ABIN1106213 Func IHC (fro) IF IHC (p) IP WB Biotin Mouse IgG1 Anmelden zum Anzeigen TLR3-7 4
1 ABIN2376228 IC IF ELISA WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN2376253 IC IF IHC WB Rabbit AA 514-657 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1175322 ICC IF IHC WB FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2467253 ICC IF IHC WB Rabbit AA 514-657 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Toll-Like Receptor 3 (TLR3) Antikörper
Reaktivität Human
(280), (207), (64), (45), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Wirt Maus
(201), (122), (39), (3), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR3 Antikörper ist konjugiert mit Biotin
(33), (30), (24), (16), (10), (8), (7), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(240), (143), (105), (90), (67), (43), (40), (37), (13), (13), (12), (7), (5), (4), (1), (1), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR3 Antikörper

Target Details TLR3 Anwendungsinformationen Handhabung Referenzen für anti-TLR3 Antikörper (ABIN2191974) Bilder
Kreuzreaktivität (Details) Cross reactivity: 4 Canine TLR3 : Yes, Mouse TLR3 : Yes
Sterilität 0.2 μm filtered
Klon TLR3-7
Isotyp IgG1
Plasmids, Primers & others

Target Details TLR3

Produktdetails anti-TLR3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR3 Antikörper (ABIN2191974) Bilder zurück nach oben
Antigen
Andere Bezeichnung Toll-Like Receptor 3 (TLR3 Antibody Abstract)
Hintergrund The monoclonal antibody TLR3.7 recognizes the 116 kDa human Toll-like receptor 3 (TLR3, CD283). Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB- dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Some forms of RNA and DNA from pathogens exhibit immutable features that distinguish them from nucleic acids of higher organisms. For example, dsRNA, is a common intermediate of viral replication and a potent indicator of infection. Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)). TLR3 is normally located in acidic endosomes where its luminal ectodomain (ECD) encounters dsRNA and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Based on the different subcellular localization of cytosolic RNA receptors and TLR3, these receptors seem to play distinct roles in anti-viral immune responses. Aliases CD283 Immunogen Human Flag-tagged TLR3 stably expressed by Ba/F3 cells
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Handhabung Referenzen für anti-TLR3 Antikörper (ABIN2191974) Bilder zurück nach oben
Applikations-hinweise For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Monocytes, granulocytes, lymphocytes, human fibroblast, MRC-5 & FS-4 cells control Negative HEK293 control
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Anwendungsinformationen Referenzen für anti-TLR3 Antikörper (ABIN2191974) Bilder zurück nach oben
Buffer PBS, containing 1 % bovine serum albumin.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-TLR3 Antikörper (ABIN2191974)

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Burgener, Jungi: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, 2008

Schreiner, Voss, Wischhusen, Dombrowski, Steinle, Lochmüller, Dalakas, Melms, Wiendl: "Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 1, pp. 118-20, 2006

Jorgenson, Young, Lesmeister, Lyddon, Misfeldt: "Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA." in: Human immunology, Vol. 66, Issue 5, pp. 469-82, 2005

Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, 2003

Matsumoto, Funami, Tanabe, Oshiumi, Shingai, Seto, Yamamoto, Seya: "Subcellular localization of Toll-like receptor 3 in human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 6, pp. 3154-62, 2003

Matsumoto, Kikkawa, Kohase, Miyake, Seya: "Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling." in: Biochemical and biophysical research communications, Vol. 293, Issue 5, pp. 1364-9, 2002