anti-Human TLR1 Antikörper für Immunohistochemistry (Frozen Sections)

Recommended TLR1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 1 (TLR1) Antikörper
  • CD281
  • TIL
  • TIL. LPRS5
  • rsc786
  • toll like receptor 1
  • toll-like receptor 1
  • TLR1
  • Tlr1
Reaktivität
Human
181
93
43
1
Wirt
Maus
147
44
17
1
Klonalität
Monoklonal
Konjugat
Dieser TLR1 Antikörper ist konjugiert mit PE
18
17
15
5
5
3
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
138
77
76
55
37
14
13
13
13
12
11
6
6
3
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN2191959
$ 560.76
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
17.311333 ABIN2191960 Func IHC (fro) FACS IHC (p) PE Mouse IgG1 Anmelden zum Anzeigen GD2-F4 6
17.311333 ABIN2191961 Func IHC (fro) FACS IHC (p) Biotin Mouse IgG1 Anmelden zum Anzeigen GD2-F4 6
17.311333 ABIN2191958 Func IHC (fro) FACS IHC (p) FITC Mouse IgG1 Anmelden zum Anzeigen GD2-F4 7
17.311333 ABIN2191957 Func IHC (fro) FACS IHC (p) Mouse IgG1 Anmelden zum Anzeigen GD2-F4 7
8.5 ABIN2479707 IHC (fro) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 3
8.5 ABIN550246 IHC (fro) WB Rabbit Anmelden zum Anzeigen Polyclonal 3
7 ABIN318756 IHC (fro) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 1
4 ABIN951276 IHC (fro) WB Rabbit IgG N-Term Anmelden zum Anzeigen Polyclonal 3
1 ABIN1106188 IHC (fro) FACS IF IHC (p) FITC Mouse IgG1 Anmelden zum Anzeigen GD2-F4 8
1 ABIN1106187 EIA IHC (fro) FACS IF IHC (p) Biotin Mouse IgG1 Anmelden zum Anzeigen GD2-F4 7
1 ABIN1106186 Func EIA IHC (fro) FACS IF IHC (p) Mouse IgG1 Anmelden zum Anzeigen GD2-F4 5
1 ABIN644686 IHC (fro) WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen Toll-Like Receptor 1 (TLR1) Antikörper
Reaktivität Human
(181), (93), (43), (1)
Wirt Maus
(147), (44), (17), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR1 Antikörper ist konjugiert mit PE
(18), (17), (15), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(138), (77), (76), (55), (37), (14), (13), (13), (13), (12), (11), (6), (6), (3), (2)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR1 Antikörper

Target Details TLR1 Anwendungsinformationen Handhabung Referenzen für anti-TLR1 Antikörper (ABIN2191959) Bilder
Kreuzreaktivität (Details) Cross reactivity: TLR2 : No, TLR4 : No
Sterilität 0.2 μm filtered
Klon GD2-F4
Isotyp IgG1
Plasmids, Primers & others

Target Details TLR1

Produktdetails anti-TLR1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR1 Antikörper (ABIN2191959) Bilder zurück nach oben
Antigen
Andere Bezeichnung Tlr1 (TLR1 Antibody Abstract)
Hintergrund The monoclonal antibody GD2.F4 reacts with human TLR1. Toll-like receptors (TLR) are highly conserved throughout evolution and play an essential role in recognizing conserved motifs found in various pathogens and initiating an appropriate innate immune response. In human, ten members of the TLR family have been identified as type I transmembrane signaling receptors containing multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Mammalian responsiveness to microbial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2 in response to bacterial lipoproteins. On the other hand, TLR 1 was shown to have the capacity to abrogate TLR4 signaling. In general, TLR1 is expressed at higher levels as compared to other TLRs. The highest expression of TLR1 is found in monocytes but it can also be expressed by macrophages, dendritic cells, B, T, and NK cells. In recent studies, several human TLR1 polymorphisms have been associated with impaired mycobacterial signaling and susceptibility to tuberculosis. Aliases CD281, toll-like receptor 1 Immunogen TLR1Fc
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Handhabung Referenzen für anti-TLR1 Antikörper (ABIN2191959) Bilder zurück nach oben
Applikations-hinweise For flow cytometry and immunohistochemistry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, dilutions have to be optimized in user's experimental setting. Positive HeLa cells transfected with TLR1 mRNA (Ref.1) control Negative Mock transfected HeLa cells (Ref.1) control
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Anwendungsinformationen Referenzen für anti-TLR1 Antikörper (ABIN2191959) Bilder zurück nach oben
Buffer PBS, containing 1 % bovine serum albumin and 0.02 % sodium azide..
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-TLR1 Antikörper (ABIN2191959)

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Månsson, Adner, Höckerfelt, Cardell: "A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation." in: Immunology, Vol. 118, Issue 4, pp. 539-48, 2006

Ritter, Mennerich, Weith, Seither et al.: "Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory ..." in: Journal of inflammation (London, England), Vol. 2, pp. 16, 2005

Ochoa, Legaspi, Hatziris, Godowski, Modlin, Sieling: "Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue." in: Immunology, Vol. 108, Issue 1, pp. 10-5, 2003

Allgemeine Veröffentlichungen

Sandor, Latz, Re, Mandell, Repik, Golenbock, Espevik, Kurt-Jones, Finberg: "Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1099-110, 2003

Visintin, Mazzoni, Spitzer, Wyllie, Dower, Segal: "Regulation of Toll-like receptors in human monocytes and dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 249-55, 2001

Wyllie, Kiss-Toth, Visintin, Smith, Boussouf, Segal, Duff, Dower: "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7125-32, 2000