anti-Human TLR1 Antikörper für Functional Studies

Recommended TLR1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 1 (TLR1) Antikörper
  • CD281
  • TIL
  • TIL. LPRS5
  • rsc786
  • toll like receptor 1
  • toll-like receptor 1
  • TLR1
  • Tlr1
Reaktivität
Human
181
92
41
1
Wirt
Maus
142
48
17
2
Klonalität
Monoklonal
Konjugat
Dieser TLR1 Antikörper ist unkonjugiert
18
17
17
5
5
3
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
134
78
77
53
36
14
13
13
12
12
11
6
5
3
2
Hersteller
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Produktnummer ABIN1106186
$ 368.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2191959 Func IHC (fro) FACS IHC (p) PE Mouse IgG1 Anmelden zum Anzeigen GD2-F4 6
1 ABIN2191961 Func IHC (fro) FACS IHC (p) Biotin Mouse IgG1 Anmelden zum Anzeigen GD2-F4 6
1 ABIN2191960 Func IHC (fro) FACS IHC (p) PE Mouse IgG1 Anmelden zum Anzeigen GD2-F4 6
1 ABIN2191958 Func IHC (fro) FACS IHC (p) FITC Mouse IgG1 Anmelden zum Anzeigen GD2-F4 7
1 ABIN2191957 Func IHC (fro) FACS IHC (p) Mouse IgG1 Anmelden zum Anzeigen GD2-F4 7
1 ABIN2153509 Func Mouse IgG1 kappa Anmelden zum Anzeigen GD2-F4 0

General

Antigen Toll-Like Receptor 1 (TLR1) Antikörper
Reaktivität Human
(181), (92), (41), (1)
Wirt Maus
(142), (48), (17), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR1 Antikörper ist unkonjugiert
(18), (17), (17), (5), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(134), (78), (77), (53), (36), (14), (13), (13), (12), (12), (11), (6), (5), (3), (2)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR1 Antikörper

Target Details TLR1 Anwendungsinformationen Handhabung Referenzen für anti-TLR1 Antikörper (ABIN1106186) Bilder
Spezifität The monoclonal antibody GD2.F4 reacts with human TLR1. Does not react with TLR2 or TLR4.
Kreuzreaktivität (Details) Species reactivity (tested):Human
Reinigung Protein G
Immunogen TLR1Fc
Klon GD2-F4
Isotyp IgG1
Plasmids, Primers & others

Target Details TLR1

Produktdetails anti-TLR1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR1 Antikörper (ABIN1106186) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD281 / TLR1 (TLR1 Antibody Abstract)
Hintergrund Toll-like receptors (TLR) are highly conserved throughout evolution and play an essential role in recognizing conserved motifs found in various pathogens and initiating an appropriate innate immune response. In human, ten members of the TLR family have been identified as type I transmembrane signaling receptors containing multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Mammalian responsiveness to microbial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2 in response to bacterial lipoproteins. On the other hand, TLR 1 was shown to have the capacity to abrogate TLR4 signaling. In general, TLR1 is expressed at higher levels as compared to other TLRs. The highest expression of TLR1 is found in monocytes but it can also be expressed by macrophages, dendritic cells, B, T, and NK cells. In recent studies, several human TLR1 polymorphisms have been associated with impaired mycobacterial signaling and susceptibility to tuberculosis.Synonyms: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Gen-ID 9606
UniProt Q15399
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Handhabung Referenzen für anti-TLR1 Antikörper (ABIN1106186) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Anwendungsinformationen Referenzen für anti-TLR1 Antikörper (ABIN1106186) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.1 % BSA
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-TLR1 Antikörper (ABIN1106186)

Produktdetails anti-TLR1 Antikörper Target Details TLR1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Panda, Qian, Mohanty, van Duin, Newman, Zhang, Chen, Towle, Belshe, Fikrig, Allore, Montgomery, Shaw: "Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 5, pp. 2518-27, 2010

Sandor, Latz, Re, Mandell, Repik, Golenbock, Espevik, Kurt-Jones, Finberg: "Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1099-110, 2003

Ochoa, Legaspi, Hatziris, Godowski, Modlin, Sieling: "Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue." in: Immunology, Vol. 108, Issue 1, pp. 10-5, 2003

Visintin, Mazzoni, Spitzer, Wyllie, Dower, Segal: "Regulation of Toll-like receptors in human monocytes and dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 249-55, 2001

Wyllie, Kiss-Toth, Visintin, Smith, Boussouf, Segal, Duff, Dower: "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7125-32, 2000