anti-Ratte (Rattus) TIRAP Antikörper für Immunohistochemistry (Frozen Sections)

Recommended TIRAP Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) Antikörper
  • mal
  • wyatt
  • BACTS1
  • Mal
  • MyD88-2
  • AA407980
  • C130027E04Rik
  • Tlr4ap
  • Wyatt
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • TIR domain containing adaptor protein
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog
  • toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • tirap
  • TIRAP
  • tirap.L
  • Tirap
Epitop
C-Term
29
22
15
5
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
149
71
38
2
2
2
1
1
1
1
Wirt
Kaninchen
114
31
5
5
Klonalität
Polyklonal
Konjugat
Dieser TIRAP Antikörper ist unkonjugiert
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
109
61
50
31
26
7
4
3
1
1
Hersteller
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Bilder

Produktnummer ABIN265134
$ 610.50
Zzgl. Versandkosten $45.00

General

Antigen Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) Antikörper
Epitop C-Term
(29), (22), (15), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(149), (71), (38), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(114), (31), (5), (5)
Klonalität
Polyklonal
Konjugat Dieser TIRAP Antikörper ist unkonjugiert
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(109), (61), (50), (31), (26), (7), (4), (3), (1), (1)
Pubmed 4 Publikationen vorhanden
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Produktdetails anti-TIRAP Antikörper

Target Details TIRAP Anwendungsinformationen Handhabung Referenzen für anti-TIRAP Antikörper (ABIN265134) Bilder
Spezifität This antibody reacts to TIRAP (C-Term).
Reinigung Purified
Immunogen Rabbit polyclonal TIRAP antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP.
Isotyp IgG
Plasmids, Primers & others

Target Details TIRAP

Produktdetails anti-TIRAP Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TIRAP Antikörper (ABIN265134) Bilder zurück nach oben
Antigen
Andere Bezeichnung TIRAP (TIRAP Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1 - 3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7)Synonyms: Adaptor protein Wyatt, MAL, MyD88 adapter-like protein, TIR domain-containing adapter protein, Toll/interleukin-1 receptor domain-containing adapter protein
Gen-ID 114609
NCBI Accession NP_001034750
UniProt P58753
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TIRAP Antikörper Target Details TIRAP Handhabung Referenzen für anti-TIRAP Antikörper (ABIN265134) Bilder zurück nach oben
Applikations-hinweise Western Blot: 0.5 to 2 μg/mL. Immunohistochemistry. Found in the cytoplasm and highly expressed in liver, kidney, spleen, skeletal muscle andheart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine,thymus, colon and brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TIRAP Antikörper Target Details TIRAP Anwendungsinformationen Referenzen für anti-TIRAP Antikörper (ABIN265134) Bilder zurück nach oben
Buffer phosphate buffered saline with 0.02 % sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Referenzen für anti-TIRAP Antikörper (ABIN265134)

Produktdetails anti-TIRAP Antikörper Target Details TIRAP Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003

ONeill, Fitzgerald, Bowie: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, 2003

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002

Bilder

Produktdetails anti-TIRAP Antikörper Target Details TIRAP Anwendungsinformationen Handhabung Referenzen für anti-TIRAP Antikörper (ABIN265134) zurück nach oben
Bilder des Herstellers
 image for anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (C-Term) antibody (ABIN265134) anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (C-Term) antibody