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General |
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Antigen | Toll-Like Receptor Adaptor Molecule 2 (TICAM2) Antikörper |
Epitop | C-Term Alternativen |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser TICAM2 Antikörper ist unkonjugiert Alternativen |
Applikation |
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-TICAM2 AntikörperTarget Details TICAM2 Anwendungsinformationen Handhabung Bilder |
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Spezifität | This antibody detects TICAM2 / TRAM. |
Kreuzreaktivität (Details) | Species reactivity (tested):Human, mouse, rat |
Reinigung | Ion exchange chromatography |
Immunogen | TIRP antibody was raised against a peptide corresponding to amino acids near the C- terminus of human TIRP. |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details TICAM2Produktdetails anti-TICAM2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | TICAM2 / TRAM (TICAM2 Antibody Abstract) |
Hintergrund | TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).Synonyms: Putative NF-kappa-B-activating protein 502, TICAM-2, TIR domain-containing adapter molecule 2, TIRAP3, TIRP, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein |
Gen-ID | 353376 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades |
AnwendungsinformationenProduktdetails anti-TICAM2 Antikörper Target Details TICAM2 Handhabung Bilder zurück nach oben |
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Applikations-hinweise |
ELISA. Western blot: 0.5 to 2 μg/mL. Immunohistochemistry on parffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-TICAM2 Antikörper Target Details TICAM2 Anwendungsinformationen Bilder zurück nach oben |
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Buffer | PBS containing 0.02 % sodium azide |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freezing and thawing. |
Lagerung | 4 °C/-20 °C |
Informationen zur Lagerung | Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. |