anti-Maus TICAM1 Antikörper für Flow Cytometry

Recommended TICAM1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antikörper
  • IIAE6
  • MyD88-3
  • PRVTIRB
  • TICAM-1
  • TRIF
  • AW046014
  • AW547018
  • trif
  • toll like receptor adaptor molecule 1
  • toll-like receptor adaptor molecule 1
  • TICAM1
  • Ticam1
  • ticam1
Reaktivität
Human, Maus
76
26
12
5
3
2
2
Wirt
Maus
71
8
6
Klonalität
Monoklonal
Konjugat
Dieser TICAM1 Antikörper ist unkonjugiert
1
Applikation
Flow Cytometry (FACS)
80
29
18
17
13
8
8
4
4
2
1
Hersteller
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Bilder

Produktnummer ABIN2665411
Preis und Verfügbarkeit auf Anfrage.

General

Antigen Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antikörper
Reaktivität Human, Maus
(76), (26), (12), (5), (3), (2), (2)
Wirt Maus
(71), (8), (6)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TICAM1 Antikörper ist unkonjugiert
(1)
Applikation Flow Cytometry (FACS)
(80), (29), (18), (17), (13), (8), (8), (4), (4), (2), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TICAM1 Antikörper

Target Details TICAM1 Anwendungsinformationen Handhabung Referenzen für anti-TICAM1 Antikörper (ABIN2665411) Bilder
Reinigung The antibody was purified by affinity chromatography.
Klon 1H4B01
Isotyp IgG2a kappa
Plasmids, Primers & others

Target Details TICAM1

Produktdetails anti-TICAM1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TICAM1 Antikörper (ABIN2665411) Bilder zurück nach oben
Antigen
Andere Bezeichnung TICAM-1 (TICAM1 Antibody Abstract)
Hintergrund TICAM-1, also known as TRIF, is an intracellular adaptor protein utilized by TLR3 and TLR4. TLR3 recognizes double stranded viral RNA and induces TICAM-1 mediated type I interferon production. The N-terminal region of TICAM-1 recruits TBK1 and IKKi, which in turn phosphorylates the interferon regulatory transcription factor IRF3. The phosphorylated IRF3 is subsequently dimerized and translocates to the nucleus, resulting in transcriptional activation of the gene encoding IFN-β. Mice lacking in TICAM-1 expression are defective in the TLR3 mediated induction of proinflamatory cytokines, suggesting that TICAM-1 is crucial for TLR3 downstream signaling. TICAM-1 also mediates TLR4-induced signaling in the presence of the adaptor molecule TRAM. The C-terminal region of TICAM-1 recruits RIP1 and induces apoptosis through FADD/caspase cascade.
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Handhabung Referenzen für anti-TICAM1 Antikörper (ABIN2665411) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Anwendungsinformationen Referenzen für anti-TICAM1 Antikörper (ABIN2665411) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.

Referenzen für anti-TICAM1 Antikörper (ABIN2665411)

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Petnicki-Ocwieja, Chung, Acosta, Ramos, Shin, Ghosh, Kobzik, Li, Hu: "TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi." in: Infection and immunity, Vol. 81, Issue 2, pp. 402-10, 2013

Riad, Westermann, Zietsch, Savvatis, Becher, Bereswill, Heimesaat, Lettau, Lassner, Dörner, Poller, Busch, Felix, Schultheiss, Tschöpe: "TRIF is a critical survival factor in viral cardiomyopathy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 2561-70, 2011

Choi, Im, Pothoulakis, Rhee: "TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5." in: The Journal of biological chemistry, Vol. 285, Issue 28, pp. 21382-90, 2010

Gais, Tiedje, Altmayr, Gaestel, Weighardt, Holzmann: "TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 10, pp. 5842-8, 2010

Han, Yang, Xu, Shu: "Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12543-50, 2010

Takeda, Akira: "Toll-like receptors in innate immunity." in: International immunology, Vol. 17, Issue 1, pp. 1-14, 2004

Bilder

Produktdetails anti-TICAM1 Antikörper Target Details TICAM1 Anwendungsinformationen Handhabung Referenzen für anti-TICAM1 Antikörper (ABIN2665411) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN2665411) anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody
Western Blotting (WB) image for anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (ABIN2665411) anti-Toll-Like Receptor Adaptor Molecule 1 (TICAM1) antibody (Image 2)