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7 | ABIN6265480 | ELISA ICC IF IHC WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
5.5 | ABIN1002907 | ICC ELISA WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 2 | ||
4 | ABIN204691 | ICC WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
4 | ABIN1030529 | ICC ELISA WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN1887455 | ICC ELISA WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN2959971 | ICC ELISA WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN1737195 | ICC WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
-12.842082 | ABIN4358028 | ICC IF IHC IHC (p) WB | Alexa Fluor 405 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358018 | ICC IF IHC IHC (p) WB | DyLight 650 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358025 | ICC IF IHC IHC (p) WB | DyLight 350 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358026 | ICC IF IHC IHC (p) WB | DyLight 405 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358030 | ICC IF IHC IHC (p) WB | Alexa Fluor 647 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358029 | ICC IF IHC IHC (p) WB | Alexa Fluor 488 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358031 | ICC IF IHC IHC (p) WB | Alexa Fluor 700 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358017 | ICC IF IHC IHC (p) WB | Biotin | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358020 | ICC IF IHC IHC (p) WB | DyLight 488 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358019 | ICC IF IHC IHC (p) WB | DyLight 680 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358021 | ICC IF IHC IHC (p) WB | DyLight 755 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358024 | ICC IF IHC IHC (p) WB | DyLight 550 | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 | ||
-12.842082 | ABIN4358014 | ICC IF IHC IHC (p) SimWes WB | Mouse | IgG1 kappa | Anmelden zum Anzeigen | 108A429 | 0 |
General |
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Antigen | TANK-Binding Kinase 1 (TBK1) Antikörper |
Reaktivität | Rind (Kuh), Hund, Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Maus Alternativen |
Klonalität (Klon) | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Simple Western (SimWes), Western Blotting (WB)
Alternativen
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22 Publikationen vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Reinigung | Protein G purified |
Immunogen | A synthetic peptide corresponding to amino acids 563-577 (YYQFKKDKAERRLAYC) of human TBK1 was used as immunogen for this antibody (NP_037386). |
Klon | 108A429 |
Isotyp | IgG1 kappa |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | TBK1 (TBK1 Antibody Abstract) |
Hintergrund | Gene Symbol: TBK1 |
Molekulargewicht | Theoretical MW: 84 kDa |
Gen-ID | 29110 |
UniProt | Q9UHD2 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikations-hinweise | Western Blot 1-2 μg/mL, Simple Western 10 μg/mL, Immunohistochemistry 1:20-1:1000, Immunocytochemistry/Immunofluorescence 1:20, Immunohistochemistry-Paraffin 1:20-1:1000In Western Blot this antibody detects a band at 80 kDa. In Simple Western only 10 - 15 μL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue. |
Kommentare |
The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1.0 mg/mL |
Buffer |
PBS Buffer contains: 0.05 % Sodium Azide |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid freeze-thaw cycles |
Lagerung | 4 °C,-20 °C |
Informationen zur Lagerung | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Gulen, Koch, Haag, Schuler, Apetoh, Villunger, Radtke, Ablasser: "Signalling strength determines proapoptotic functions of STING." in: Nature communications, Vol. 8, Issue 1, pp. 427, 2018 Von den Autoren verwendete Methode: Western Blotting (WB) Kwon, Park, Sesaki, Kang: "Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission." in: Biochemical and biophysical research communications, Vol. 493, Issue 1, pp. 737-743, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) Slowicka, Vereecke, Mc Guire, Sze, Maelfait, Kolpe, Saelens, Beyaert, van Loo: "Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling." in: European journal of immunology, Vol. 46, Issue 4, pp. 971-80, 2016 (Probematerial (Species): Mouse (Murine)). Weitere Details: Western Blotting Mukawera, Chartier, Williams, Pagano, Lapointe, Grandvaux: "Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines." in: Redox biology, Vol. 6, pp. 9-18, 2015 (Probematerial (Species): Human). Weitere Details: Western Blotting Yu, Croxen, Marchiando, Ferreira, Cadwell, Foster, Finlay: "Autophagy facilitates Salmonella replication in HeLa cells." in: mBio, Vol. 5, Issue 2, pp. e00865-14, 2014 (Probematerial (Species): Human). Weitere Details: Western Blotting Conlon, Burdette, Sharma, Bhat, Thompson, Jiang, Rathinam, Monks, Jin, Xiao, Vogel, Vance, Fitzgerald: "Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5216-25, 2013 Tamassia, Bazzoni, Le Moigne, Calzetti, Masala, Grisendi, Bussmeyer, Scutera, De Gironcoli, Costantini, Musso, Cassatella: "IFN-β expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 3, pp. 1500-9, 2012 Weitere Details: Western Blotting Delhase, Kim, Lee, Naiki-Ito, Chen, Ahn, Murata, Kim, Lautsch, Kobayashi, Shirai, Karin, Nakanishi: "TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. E177-86, 2012 Ogasawara, Sasaki, Itoh, Tokudome, Kondo, Ito, Tanida, Kamiya, Kataoka, Joh, Kasugai: "Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction." in: Journal of clinical biochemistry and nutrition, Vol. 48, Issue 2, pp. 154-60, 2011 (Probematerial (Species): Human). Weitere Details: Western Blotting Berthet, Damien, Hamzeh-Cognasse, Pozzetto, Garraud, Cognasse: "Toll-like receptor 4 signal transduction in platelets: novel pathways." in: British journal of haematology, Vol. 151, Issue 1, pp. 89-92, 2010 (Probematerial (Species): Human). Weitere Details: Western Blotting Marchlik, Thakker, Carlson, Jiang, Ryan, Marusic, Goutagny, Kuang, Askew, Roberts, Benoit, Zhou, Ling, Pfeifer, Stedman, Fitzgerald, Lin, Hall: "Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality." in: Journal of leukocyte biology, Vol. 88, Issue 6, pp. 1171-80, 2010 (Probematerial (Species): Mouse (Murine)). Weitere Details: Western Blotting Joung, Park, Rani, Takeuchi, Akira, Lee: "Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 1, pp. 499-507, 2010 Weitere Details: Western Blotting Radtke, ORiordan: "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1." in: Cellular microbiology, Vol. 10, Issue 11, pp. 2197-207, 2008 McCoy, Carpenter, Pålsson-McDermott, Gearing, ONeill: "Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation." in: The Journal of biological chemistry, Vol. 283, Issue 21, pp. 14277-85, 2008 (Probematerial (Species): Human). Weitere Details: Western Blotting Tamassia, Le Moigne, Rossato, Donini, McCartney, Calzetti, Colonna, Bazzoni, Cassatella: "Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 6563-73, 2008 (Probematerial (Species): Human). Weitere Details: Western Blotting Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: "Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code." in: Journal of virology, Vol. 81, Issue 11, pp. 5929-39, 2007 Aksoy, Albarani, Nguyen, Laes, Ruelle, De Wit, Willems, Goldman, Goriely: "Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells." in: Blood, Vol. 109, Issue 7, pp. 2887-93, 2007 (Probematerial (Species): Human). Weitere Details: Western Blotting Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: "Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer." in: Molecular cancer research : MCR, Vol. 5, Issue 1, pp. 87-94, 2007 (Probematerial (Species): Human). Weitere Details: Western Blotting Tamassia, Le Moigne, Calzetti, Donini, Gasperini, Ear, Cloutier, Martinez, Fabbri, Locati, Mantovani, McDonald, Cassatella: "The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 7344-56, 2007 (Probematerial (Species): Human). Sankar, Chan, Romanow, Li, Bates: "IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines." in: Cellular signalling, Vol. 18, Issue 7, pp. 982-93, 2006 (Probematerial (Species): Human). |
BilderProduktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben |
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Bilder des Herstellers |
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