anti-Human TANK-Binding Kinase 1 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended TANK-Binding Kinase 1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
TANK-Binding Kinase 1 (TBK1) Antikörper
  • nak
  • t2k
  • TBK1
  • wu:fk70c05
  • zgc:136548
  • NAK
  • T2K
  • 1200008B05Rik
  • AI462036
  • AW048562
  • TANK binding kinase 1 L homeolog
  • TANK binding kinase 1
  • TANK-binding kinase 1
  • tbk1.L
  • TBK1
  • tbk1
  • Tbk1
Epitop
AA 150-200, pSer172
20
19
18
11
7
7
5
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
136
88
51
30
29
10
10
9
8
5
5
4
3
2
2
2
2
1
1
Wirt
Kaninchen
105
37
13
Klonalität
Polyklonal
Konjugat
Unkonjugiert
10
10
9
8
6
5
3
3
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
136
71
65
34
24
18
9
6
3
2
2
2
Optionen
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Bilder

Produktnummer ABIN746363
$ 328.90
Zzgl. Versandkosten $45.00

General

Antigen TANK-Binding Kinase 1 (TBK1) Antikörper
Epitop AA 150-200, pSer172
(20), (19), (18), (11), (7), (7), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(136), (88), (51), (30), (29), (10), (10), (9), (8), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(105), (37), (13)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(10), (10), (9), (8), (6), (5), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(136), (71), (65), (34), (24), (18), (9), (6), (3), (2), (2), (2)
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Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Spezifität This phosphorylation site is homologous across the listed species.
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Tbk1 (TBK1 Antibody Abstract)
Hintergrund

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

Subcellular location: Cytoplasm

Synonyms: NAK, T2K, Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, TANK-binding kinase 1, TBK1

Gen-ID 29110
UniProt Q9UHD2
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) (AA 150-200), (pSer172) antibody (ABIN746363) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Phospho-...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TANK-Binding Kinase 1 (TBK1) (AA 150-200), (pSer172) antibody (ABIN746363) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-TBK1 (Ser172)...