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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
---|---|---|---|---|---|---|---|---|---|---|
1 | ABIN754350 | IHC (p) WB | Biotin | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN754348 | IF (p) IHC (p) WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) Antikörper |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser TAB1 Antikörper ist konjugiert mit HRP Alternativen |
Applikation |
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-TAB1 AntikörperTarget Details TAB1 Anwendungsinformationen Handhabung Bilder |
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Reinigung | Purified by Protein A. |
Immunogen | KLH conjugated synthetic peptide derived from human MAP3K7IP1/TAB1 |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details TAB1Produktdetails anti-TAB1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | Tab1 (TAB1 Antibody Abstract) |
Hintergrund |
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1. Synonyms: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TAB1, MAP3K7IP1 |
Gen-ID | 10454 |
Pathways | TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades |
AnwendungsinformationenProduktdetails anti-TAB1 Antikörper Target Details TAB1 Handhabung Bilder zurück nach oben |
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Applikations-hinweise |
WB 1:100-1000 IHC-P 1:100-500 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-TAB1 Antikörper Target Details TAB1 Anwendungsinformationen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin. |
Konservierungs-mittel | Gentamicin sulfate |
Vorsichtsmaßnahmen | This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase. |
Lagerung | 4 °C |
Informationen zur Lagerung | Store at 4°C |
Haltbarkeit | 12 months |