anti-Maus LBP Antikörper für Blocking Reagent

Recommended LBP Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Lipopolysaccharide Binding Protein (LBP) Antikörper
  • BPIFD2
  • Bpifd2
  • Ly88
  • LPSBP
  • LBP
  • BmCTL21
  • lipopolysaccharide binding protein
  • C-type lectin 21
  • lipopolysaccharide-binding protein
  • LBP
  • Lbp
  • CTL21
  • LOC100472839
Reaktivität
Maus
84
63
29
11
9
7
4
3
3
2
2
1
Wirt
Ratte
83
38
26
3
Klonalität
Monoklonal
Konjugat
Dieser LBP Antikörper ist unkonjugiert
8
4
3
1
1
1
1
1
1
1
1
1
1
Applikation
Blocking Reagent (BR), Functional Studies (Func), Immunoassay (IA), Western Blotting (WB)
102
75
44
26
17
17
11
9
5
4
3
3
3
3
2
1
1
1
1
1
Optionen
Hersteller
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Produktnummer ABIN2191765
$ 493.97
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2191766 BR Func IA WB Rat Anmelden zum Anzeigen RR433-8 2

General

Antigen Lipopolysaccharide Binding Protein (LBP) Antikörper
Reaktivität Maus
(84), (63), (29), (11), (9), (7), (4), (3), (3), (2), (2), (1)
Wirt Ratte
(83), (38), (26), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser LBP Antikörper ist unkonjugiert
(8), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Blocking Reagent (BR), Functional Studies (Func), Immunoassay (IA), Western Blotting (WB)
(102), (75), (44), (26), (17), (17), (11), (9), (5), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-LBP Antikörper

Target Details LBP Anwendungsinformationen Handhabung Referenzen für anti-LBP Antikörper (ABIN2191765) Bilder
Sterilität 0.2 μm filtered
Klon M330-19
Plasmids, Primers & others

Target Details LBP

Produktdetails anti-LBP Antikörper Anwendungsinformationen Handhabung Referenzen für anti-LBP Antikörper (ABIN2191765) Bilder zurück nach oben
Antigen
Andere Bezeichnung Lipopolysaccharide Binding Protein (LBP Antibody Abstract)
Hintergrund The monoclonal antibody M330-19 reacts highly specific with mouse natural and recombinant LBP. The antibody is a type I antibody blocking the LPS binding to LBP. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process

Anwendungsinformationen

Produktdetails anti-LBP Antikörper Target Details LBP Handhabung Referenzen für anti-LBP Antikörper (ABIN2191765) Bilder zurück nach oben
Applikations-hinweise For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For neutralization of biological activity dilutions have to be made according to the amounts LBP to be inactivated. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added. Please inquire for availability of azide free solutions.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-LBP Antikörper Target Details LBP Anwendungsinformationen Referenzen für anti-LBP Antikörper (ABIN2191765) Bilder zurück nach oben
Buffer PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Haltbarkeit 12 months

Referenzen für anti-LBP Antikörper (ABIN2191765)

Produktdetails anti-LBP Antikörper Target Details LBP Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Le Roy, Di Padova, Adachi, Glauser, Calandra, Heumann: "Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against gram-negative bacteria." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 5, pp. 2759-65, 2001

Le Roy, Di Padova, Tees, Lengacher, Landmann, Glauser, Calandra, Heumann et al.: "Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7454-60, 1999