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Following spring viremia of carp virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp virus. data provide evidence that fish and mammals have evolved a similar IRF-dependent regulatory mechanism fine-tuning IFN gene activation.
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
The miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar)
Differences in transcription kinetics between IRF-7 and STAT1 indicate that genes are regulated through different pathways. Infection of TO cells with ISAV induced early synthesis of STAT1 mRNA, whereas IRF-7 transcripts were upregulated later.
SOCS1/3-mediated degradation of IFN regulatory factor 7 directly regulates TLR7 signaling and type I IFN production in pDCs.
Ablation of inflammsome components reduces SOCS1 induction, and relieves its inhibition on MyD88-IRF7-dependent-IFN-I signaling, leading to high levels of IFN-alpha/beta production and host survival.
cFLIP appears to bind to IKKalpha to prevent IKKalpha from phosphorylating and activating IRF7.
our results suggest that expression of IRF7 is one of the metastatic effectors of LMP1 signalling in Epstein-Barr virus-associated nasopharyngeal cancer
Hypomethylation of the IRF7 promoter might play a role in systemic sclerosis pathogenesis, probably through promoting the IRF7 expression in PBMCs of patients with SSc.
Results showed that INF-lambda serum concentration was increased in Alzheimer's disease (AD) and mild cognitive impairment (MCI) carrying the IFNL3 T allele compared to healthy controls (HC). Anti-HSV-1 Ab titers were higher in AD and MCI individuals carrying the IRF7 AA genotype compared to HC. IFNL3 rs12979860 and IRF7 rs6598008 polymorphisms may modulate immune responses against HSV-1 via their effect on the IFN-lam...
IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta-mediated NK activity.
The MYC is shown to be recruited to the IRF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 for its repression.
S100A9 knockdown almost completely abrogated the effects of IRF7 deletion on granulocytic myeloid-derived suppressor cells (G-MDSC) development and tumor metastasis. IRF7 represents a novel regulator for G-MDSC development in cancer and may have predictive value for tumor progression.
the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells.
We show that IRF-7 siRNA knockdown enhanced LPS-induced IL-10 production in human monocyte-derived macrophages, and USP-18 overexpression attenuated LPS-induced production of IL-10 in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18, USP41, IL10, and IRF7. An independent cohort confirmed LPS induction of USP41 and IL10 genes
KSHV-encoded viral IRF4 interacts with the host IRF7 and inhibits interferon-alpha production.
The adaptor molecule RAIDD coordinates IKKepsilon and IRF7 interaction to ensure efficient expression of type I interferon.
Bcl6, by interacting with the co-factors NcoR2 and HDAC3, plays a pivotal role in controlling IRF7 induction and antiviral signaling priming.
Human IRF7 was shown to be essential for interferon type I-dependent protective immunity against primary influenza. (Review)
The IRF7 GG genotype associate with Cognitive Decline and Dementia.
IRF7 cleavage by the 3C protease of enterovirus D68 abrogated its capacity to activate type I interferon expression and limit virus replication.
Viral infection induced DAPK1-IRF7 and DAPK1-IRF3 interactions and overexpression of DAPK1 enhanced virus-induced activation of the interferon-stimulated response element (ISRE) and IFN-beta promoters and the expression of the IFNB1 gene.
Interferon regulatory factor 7 (IRF7) is a direct target of miR-762 and overexpression of miR-762 reduced expression of IRF7.
Data indicate that the type-I interferon master regulator gene interferon regulatory factor 7 (IRF7) is only hypomethylated in lupus patients with renal involvement.
Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses.
IRF7 represents a novel regulator of granulocytic myeloid-derived suppressor cells development in cancer, which may have predictive value for tumor progression.
a specific requirement for IRF7 in autoantibody production and uncovers a new layer of complexity in the pathogenesis of Systemic lupus erythematosus (SLE).
MiR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.
IRF7 directly binds to the two conserved IRF binding sites on the USP25 promoter to drive transcription of Usp25.
poly I:C augments IFN-gamma-induced NO production at the transcriptional level via enhanced IRF7 activation
IRF7 protects against vascular smooth muscle cell proliferation.
Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo.
Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Authors show that the capacity to undergo pro- to anti-inflammatory (M1-to-M2) phenotype switch is controlled by the transcription factor interferon regulatory factor 7 (IRF7) that is down-regulated by the TGFbeta1 pathway.
Our data highlight a pivotal role of CCL7 and IRF-7 in rhinovirus-induced inflammation
These results establish a dominant protective role for MAVS, IRF-3 and IRF-7, and IFNAR in restricting Oropouche virus infection and tissue injury and suggest that IFN signaling in nonmyeloid cells contributes to the host defense.
IRF7 suppresses antiparasitic immunity in the spleen, while IFNAR1-mediated, but IRF7-independent, signaling contributes to pathology in the brain during experimental blood-stage malaria.
IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice
IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-kappaB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy.
MAP3K8 mediates the phosphorylation and repression of IRF3 homodimers to promote greater transcriptional activity through utilization of IRF3:IRF7 heterodimers.
the combined actions of IRF-3 and IRF-7 are necessary for efficient control of early DENV infection; and the late, IRF-3- and IRF-7-independent pathway contributes to anti-DENV immunity.
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7
Key regulators involved in Porcine circovirus 2 infection were identified as IFNbeta, DDX58 (RIG-I), and IRF7.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.
N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
interferon regulatory factor 7
, interferon regulatory factor 7-like
, interferon regulatory factor-7H
, interferon regulatory factor-7