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Following spring viremia of carp (zeige ANKRD1 Proteine) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (zeige ANKRD1 Proteine) virus. data provide evidence that fish and mammals have evolved a similar IRF (zeige TRIM63 Proteine)-dependent regulatory mechanism fine-tuning IFN gene activation.
Functions of the two zebrafish MAVS (zeige MAVS Proteine) variants are opposite in the induction of IFN1 by targeting IRF7
The miR (zeige MYLIP Proteine)-142a-3p regulates HSC (zeige FUT1 Proteine) formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
MyD88 (zeige MYD88 Proteine) interacts with interferon (zeige IFNA Proteine) regulatory factor (IRF) 3 (zeige IRF3 Proteine) and IRF7 in Atlantic salmon (Salmo salar)
Differences in transcription kinetics between IRF-7 and STAT1 (zeige STAT1 Proteine) indicate that genes are regulated through different pathways. Infection of TO cells with ISAV induced early synthesis of STAT1 (zeige STAT1 Proteine) mRNA, whereas IRF-7 transcripts were upregulated later.
our results suggest that expression of IRF7 is one of the metastatic effectors of LMP1 (zeige PDLIM7 Proteine) signalling in Epstein-Barr virus-associated nasopharyngeal cancer
Hypomethylation of the IRF7 promoter might play a role in systemic sclerosis pathogenesis, probably through promoting the IRF7 expression in PBMCs of patients with SSc (zeige CYP11A1 Proteine).
Results showed that INF-lambda serum concentration was increased in Alzheimer's disease (AD) and mild cognitive impairment (MCI (zeige MCIN Proteine)) carrying the IFNL3 (zeige IL28B Proteine) T allele compared to healthy controls (HC). Anti-HSV-1 Ab titers were higher in AD and MCI (zeige MCIN Proteine) individuals carrying the IRF7 AA genotype compared to HC. IFNL3 (zeige IL28B Proteine) rs12979860 and IRF7 rs6598008 polymorphisms may modulate immune responses against HSV-1 via their effect on the IFN-lam (zeige TSC1 Proteine)...
IRF7 plays a role in reducing bone metastasis of prostate cancer by IFN-beta (zeige IFNB1 Proteine)-mediated NK activity.
The MYC (zeige MYC Proteine) is shown to be recruited to the IRF7 promoter region through interaction with nuclear receptor corepressor 2/histone deacetylase 3 (zeige HDAC3 Proteine) for its repression.
S100A9 knockdown almost completely abrogated the effects of IRF7 deletion on granulocytic myeloid-derived suppressor cells (G-MDSC) development and tumor metastasis. IRF7 represents a novel regulator for G-MDSC development in cancer and may have predictive value for tumor progression.
the transcription factor NFATC3 (zeige NFATC3 Proteine) binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells.
We show that IRF-7 siRNA knockdown enhanced LPS (zeige IRF6 Proteine)-induced IL-10 (zeige IL10 Proteine) production in human monocyte-derived macrophages, and USP-18 (zeige USP18 Proteine) overexpression attenuated LPS (zeige IRF6 Proteine)-induced production of IL-10 (zeige IL10 Proteine) in RAW264.7 cells. Quantitative PCR confirmed upregulation of USP18 (zeige USP18 Proteine), USP41, IL10 (zeige IL10 Proteine), and IRF7. An independent cohort confirmed LPS (zeige IRF6 Proteine) induction of USP41 and IL10 (zeige IL10 Proteine) genes
KSHV-encoded viral IRF4 (zeige IRF4 Proteine) interacts with the host IRF7 and inhibits interferon-alpha (zeige IFNA Proteine) production.
The adaptor molecule RAIDD (zeige CRADD Proteine) coordinates IKKepsilon (zeige IKBKE Proteine) and IRF7 interaction to ensure efficient expression of type I interferon (zeige IFNA Proteine).
IRF7 represents a novel regulator of granulocytic myeloid-derived suppressor cells development in cancer, which may have predictive value for tumor progression.
a specific requirement for IRF7 in autoantibody production and uncovers a new layer of complexity in the pathogenesis of Systemic lupus erythematosus (SLE).
MiR (zeige MLXIP Proteine)-144 reduces the antiviral response by attenuating the TRAF6 (zeige TRAF6 Proteine)-IRF7 pathway to alter the cellular antiviral transcriptional landscape.
Bcl6 (zeige BCL6 Proteine), by interacting with the co-factors NcoR2 and HDAC3 (zeige HDAC3 Proteine), plays a pivotal role in controlling IRF7 induction and antiviral signaling priming.
IRF7 directly binds to the two conserved IRF (zeige TRIM63 Proteine) binding sites on the USP25 (zeige USP25 Proteine) promoter to drive transcription of Usp25 (zeige USP25 Proteine).
poly I:C augments IFN-gamma-induced (zeige SAMHD1 Proteine) NO production at the transcriptional level via enhanced IRF7 activation
IRF7 protects against vascular smooth muscle cell proliferation.
Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo.
Data suggest that Trim35 (tripartite motif-containing 35 (zeige TRIM35 Proteine)) down-regulates type I interferon (zeige IFNA Proteine) production in dendritic cells via toll (zeige TLR4 Proteine)-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Key regulators involved in Porcine circovirus 2 infection were identified as IFNbeta, DDX58 (RIG-I (zeige DDX58 Proteine)), and IRF7.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.
N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
interferon regulatory factor 7
, interferon regulatory factor 7-like
, interferon regulatory factor-7H
, interferon regulatory factor-7