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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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16.563305 | ABIN3020651 | FACS IP WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
14.5 | ABIN682603 | IF (p) IHC (p) WB | Rabbit | IgG | AA 420-470 | Anmelden zum Anzeigen | Polyclonal | 3 | ||
13.751972 | ABIN5518764 | IHC (p) WB | Rabbit | IgG | AA 31-67, N-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
12.811332 | ABIN6388341 | ELISA WB | Rabbit | IgG | AA 410-490 | Anmelden zum Anzeigen | Polyclonal | 0 | ||
10.751972 | ABIN2736992 | FACS IP WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
9.251972 | ABIN2475148 | WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 2 | ||
7.751972 | ABIN2780566 | WB | Rabbit | N-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
7.751972 | ABIN6262657 | ELISA IHC WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
7.751972 | ABIN1030452 | IHC ELISA WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
7 | ABIN318755 | WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 2 | ||
7 | ABIN214503 | IHC IHC (p) WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
5.993722 | ABIN5946619 | FACS ICC IF IHC IHC (p) IP WB | Rabbit | IgG | Anmelden zum Anzeigen | SC0617 | 0 | |||
5.5 | ABIN1002560 | IHC ELISA WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 4 | ||
4.751972 | ABIN2780567 | WB | Rabbit | Middle Region | Anmelden zum Anzeigen | Polyclonal | 0 | |||
4.751972 | ABIN6272122 | ELISA WB | Rabbit | IgG | pSer477 | Anmelden zum Anzeigen | Polyclonal | 0 | ||
4.751972 | ABIN5869223 | WB | Rabbit | pSer477 | Anmelden zum Anzeigen | Polyclonal | 0 | |||
4.751972 | ABIN5869225 | WB | Rabbit | Anmelden zum Anzeigen | Polyclonal | 0 | ||||
4.751972 | ABIN3059751 | WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
4.751972 | ABIN306986 | WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 4 | ||
4 | ABIN265129 | WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 4 |
General |
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Antigen | Interferon Regulatory Factor 7 (IRF7) Antikörper |
Epitop | pSer471, pSer472, AA 450-490 Alternativen |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser IRF7 Antikörper ist unkonjugiert Alternativen |
Applikation |
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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3 Publikationen vorhanden |
Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-IRF7 AntikörperTarget Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder |
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Reinigung | Purified by Protein A. |
Immunogen | KLH conjugated synthetic phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472 |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details IRF7Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | Irf7 (IRF7 Antibody Abstract) |
Hintergrund |
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. Subcellular location: Nucleus Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7 |
Gen-ID | 3665 |
UniProt | Q92985 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie |
AnwendungsinformationenProduktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben |
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Applikations-hinweise |
WB 1:100-1000 IHC-P 1:100-500 IF(IHC-P) 1:50-200 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Lagerung | -20 °C |
Informationen zur Lagerung | Store at -20°C |
Haltbarkeit | 12 months |
Referenzen für anti-IRF7 Antikörper (ABIN742703)Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, 2015 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: Lung Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, 2014 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, 2013 Von den Autoren verwendete Methode: Western Blotting (WB) |
BilderProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) zurück nach oben |
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Bilder des Herstellers |
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